{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:35:32Z","timestamp":1774593332283,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012155","name":"National Institute for Medical Research Development","doi-asserted-by":"publisher","award":["4021102"],"award-info":[{"award-number":["4021102"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Several conclusions have emerged regarding the impact of COVID\u201019 on the male reproductive system. This systematic review and meta\u2010analysis aimed to provide a comprehensive update on the relationship between COVID\u201019 and male reproductive health. We investigated the effects of SARS\u2010CoV\u20102 on various semen parameters, including semen volume, sperm concentration, sperm total count, total motility, progressive motility, morphology, and DNA fragmentation index (DFI). A literature review was conducted on all studies evaluating the impact of SARS\u2010CoV\u20102 infection on male infertility from the beginning of 2019 through December 2023. Main electronic databases such as PubMed, Scopus, Cochrane Library, and Web of Science were used. The research question was based on the PECO framework, focusing on (Population) exposed to SARS\u2010CoV\u20102 (Exposure), compared to uninfected men (Comparator), with conventional sperm parameters as the measured Outcome. The studies were divided into two groups for analysis: between\u2010group comparisons, which compared sperm parameters of men recovered from COVID\u201019 to uninfected controls, and within\u2010subject comparisons, which assessed sperm parameters in the same individuals before and after infection. Standardized mean differences (SMD) were calculated as effect sizes with 95% confidence intervals (CI) for each outcome. The DerSimonian\u2010Laird method estimated between\u2010study variance (\u03c4\n                    <jats:sup>2<\/jats:sup>\n                    ), while the Jackson method calculated confidence intervals for \u03c4\n                    <jats:sup>2<\/jats:sup>\n                    and\n                    <jats:italic>\u03c4<\/jats:italic>\n                    . Publication bias was assessed using funnel plots and Egger's test. This meta\u2010analysis included two types of cohort studies: single\u2010arm studies and those with a control group. In the single\u2010arm studies, a statistically significant decrease in semen volume (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0023) was observed. Additionally, in the cohort studies with controls, there were statistically significant reductions in sperm concentration (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001), total count (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0001), total motility (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0009), progressive sperm motility (0.0391), and DFI (0.04). This is the most up\u2010to\u2010date systematic review and meta\u2010analysis incorporating cohort study data. The findings provide compelling evidence that SARS\u2010CoV\u20102 infection adversely affects male reproductive health, particularly in terms of semen quality. The analysis reveals significant reductions in key semen parameters, including sperm count, concentration, total motility, and progressive motility. Adult maleand DFI.\n                  <\/jats:p>","DOI":"10.1002\/rmv.70128","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T12:19:23Z","timestamp":1774095563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of SARS\u2010CoV\u20102 on Male Infertility: A Systematic Review and Meta\u2010Analysis of Cohort Studies"],"prefix":"10.1002","volume":"36","author":[{"given":"Mehdi Gholami","family":"Barzoki","sequence":"first","affiliation":[{"name":"Department of Virology Faculty of Medical Sciences Tarbiat Modares University  Tehran Iran <!--Query ID=\"q1\" Text=\"AUTHOR: Please check and confirm that authors and their affiliations are correct.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Farahmand","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Javad","family":"Mahmodi","sequence":"additional","affiliation":[{"name":"Department of Virology Faculty of Medical Sciences Tarbiat Modares University  Tehran Iran <!--Query ID=\"q1\" Text=\"AUTHOR: Please check and confirm that authors and their affiliations are correct.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8546-8750","authenticated-orcid":false,"given":"Naser","family":"Amirjannati","sequence":"additional","affiliation":[{"name":"Reproductive Biotechnology Research Center Avicenna Research Institute ACECR  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2741-2745","authenticated-orcid":false,"given":"Somayeh Shatizadeh","family":"Malekshahi","sequence":"additional","affiliation":[{"name":"Department of Virology Faculty of Medical Sciences Tarbiat Modares University  Tehran Iran <!--Query ID=\"q1\" Text=\"AUTHOR: Please check and confirm that authors and their affiliations are correct.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,21]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13128"},{"issue":"1","key":"e_1_2_14_3_1","first-page":"19","article-title":"SARS\u2010CoV\u20102 Related Viral Respiratory Co\u2010Infections: A Narrative Review","volume":"22","author":"Malekshahi S. 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