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In this review, we provide updated data from multiple African countries, revealing high HPV35 prevalence rates in women with precancerous and ICC lesions. Among women with ICC, the highest prevalence of HPV35 was observed in Mozambique (30% and 19%), Kenya (26% and 22%), South Africa (17%), Burkina Faso (13.7%), Zimbabwe (11%), and Tanzania (11.2%). Similarly, in women with precancerous lesions (LSIL\/HSIL\/CIN1\u20103), the highest rates were recorded in Tanzania (26%) and Botswana (23% and 20%). These findings highlight a significant and underappreciated burden of HPV35\u2010associated cervical disease in African populations, particularly among women with precancerous and invasive lesions. The findings call for an urgent re\u2010evaluation of current HPV vaccination strategies to consider the inclusion of HPV35, which could profoundly enhance the effectiveness of cervical cancer prevention programs in sub\u2010Saharan Africa.<\/jats:p>","DOI":"10.1002\/rmv.70129","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:12:19Z","timestamp":1773011539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Burden of HPV35 in African Cervical Pathologies: Prevalence, Contributing Factors, and Vaccine Prospects"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-7852","authenticated-orcid":false,"given":"Alltalents T.","family":"Murahwa","sequence":"first","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine\/Division of Medical Virology University of Cape Town  Cape Town South 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