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Antiviral therapy approaches for HCMV are often limited by toxicities and the risk of developing antiviral drug resistance. This review article (Part 2) provides an overview of current antiviral pharmacotherapies for HCMV and the application of virus\u2010specific adoptive T cell therapies for the prevention or treatment of HCMV reactivation in allo\u2010HSCT recipients. The number of available antiviral drugs for HCMV is expanding, and letermovir primary prophylaxis is increasingly being adopted due to its favourable safety profile. Treatment resistant\/refractory infections, end\u2010organ disease, and late HCMV reactivations after antiviral therapy withdrawal continue to pose challenges. Adoptive HCMV\u2010specific T cell therapies are a promising strategy for promoting immune\u2010mediated control of HCMV reactivation in allo\u2010HSCT recipients. The administration of HCMV\u2010specific T cell products, generated through ex vivo expansion of donor\u2010derived or partially HLA matched, third party HCMV\u2010specific T cells, have demonstrated efficacy in combatting clinically significant HCMV infection in clinical trials. Adoptive HCMV\u2010specific T cell therapies represent a powerful alternative approach for managing drug resistant HCMV infections in allo\u2010HSCT recipients and reducing the reliance on antiviral pharmacotherapies.<\/jats:p>","DOI":"10.1002\/rmv.70135","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:14:42Z","timestamp":1774948482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Human Cytomegalovirus Infection in Haematopoietic Stem Cell Transplant Recipients and CAR\u2010T Cell Recipients\u2014\n                    <i>PART 2: Antiviral Therapy and Virus\u2010Specific T Cell Therapy for HCMV in Allo\u2010HSCT<\/i>"],"prefix":"10.1002","volume":"36","author":[{"given":"Gaurav","family":"Sutrave","sequence":"first","affiliation":[{"name":"Blood Transplant and Cell Therapies Program Department of Haematology Westmead Hospital  Sydney New South Wales 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