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Endothelial\u2010to\u2010mesenchymal transition (EndMT) has recently emerged as a critical, yet underrecognized, pathway hijacked by oncoviral pathogens to modulate endothelial plasticity within the cardiovascular system. Accumulating evidence indicates that Oncogenic and non\u2010oncogenic viruses, including Kaposi's sarcoma\u2013associated herpesvirus (KSHV\/HHV\u20108), severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), human immunodeficiency virus (HIV), and other endothelial\u2010tropic viruses, directly manipulate host signalling networks, such as TGF\u2010\u03b2, Wnt\/\u03b2\u2010catenin, Notch, and NF\u2010\u03baB, to induce partial or complete EndMT. This virus\u2010driven EndMT contributes to vascular remodelling, chronic inflammation, aberrant angiogenesis, and the development of oncoviral\u2010associated cardiovascular pathology and vascular tumours. The present review integrates current virological and mechanistic insights into EndMT as a hijacked host process, highlighting its role at the virus\u2013host interface and discussing emerging antiviral and pathway\u2010targeted strategies aimed at limiting oncovirus\u2010mediated endothelial dysfunction.<\/jats:p>","DOI":"10.1002\/rmv.70143","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T17:30:40Z","timestamp":1775928640000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oncovirus\u2010Driven Endothelial Plasticity: Endothelial\u2010to\u2010Mesenchymal Transition as a Hijacked Pathway in Oncoviral Cardiovascular Pathogenesis"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4332-8095","authenticated-orcid":false,"given":"Ming","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Internal Medicine the Second Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Internal Medicine the Second Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4607-9474","authenticated-orcid":false,"given":"Zhuo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Internal Medicine the Second Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Internal Medicine the Second Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136353"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/18756557mtawsmja3w"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.06.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116180"},{"key":"e_1_2_11_6_1","article-title":"Endothelial to Mesenchymal Transition in Cardiovascular Diseases: Molecular Insights and Clinical Perspectives","author":"Hall I. 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