{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:46:46Z","timestamp":1782409606795,"version":"3.54.5"},"reference-count":91,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Group B Coxsackieviruses (CV\u2010B), like other enteroviruses, are essentially transmitted from person to person through the faecal\u2010oral route. However, vertical transmission from mother to infant, through transplacental passage or inhalation of contaminated cervical swabs during delivery, can also occur. This underestimated route of CV\u2010B transmission has been associated with serious consequences, mainly abortion, stillbirth, congenital malformations, as well as serious morbidity and mortality in the newborns. Based on a systematic review of clinical observations, this paper explains the mechanisms of CV\u2010B vertical transmission and its diverse consequences, with a special focus on associated diseases. Preventive measures, therapeutic strategies, and recommendations are also addressed.<\/jats:p>","DOI":"10.1002\/rmv.70144","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T16:46:23Z","timestamp":1775234783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vertical Transmission of Type B Coxsackieviruses: A Systematic Review Emphasising Clinical Evidence and Seriousness of a Neglected Issue"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-4109","authenticated-orcid":false,"given":"Aymen","family":"Halouani","sequence":"first","affiliation":[{"name":"Laboratory of Transmissible Diseases and Biologically Active Substances Faculty of Pharmacy of Monastir University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hela","family":"Jaidane","sequence":"additional","affiliation":[{"name":"Laboratory of Transmissible Diseases and Biologically Active Substances Faculty of Pharmacy of Monastir University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450\u2010197108000\u201000144"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705\u2010021\u201005156\u20101"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001840"},{"key":"e_1_2_10_5_1","first-page":"490","volume-title":"Fields Virology","author":"Pallansch M. A.","year":"2013"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2024.199367"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60687-8_4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60687-8_2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000235686.50060.2b"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010540\u201075546\u20103"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23518"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010021\u201002599\u2010y"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100031\u20101296027"},{"key":"e_1_2_10_14_1","first-page":"53","article-title":"Infections With Echoviruses and Coxsackieviruses in Late Pregnancy","volume":"71","author":"Magnius L.","year":"1990","journal-title":"Scandinavian Journal of Infectious Diseases \u2010 Supplementum"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480\u2010200102000\u201000012"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010004\u20101408\u2010y"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(88)90071\u20103"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm195611082551902"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.22.5.857"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(63)80431\u2010x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1963.88.3P2.342"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1968.03140010003001"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1968.02100020247003"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1970.2.issue\u20101.04"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121388"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/5.6.1019"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf02123800"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454\u2010198501000\u201000009"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.3.404"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/s1064744995000366"},{"issue":"5","key":"e_1_2_10_31_1","first-page":"321","article-title":"Congenital Coxsackievirus B5 Infection: Report of One Case","volume":"46","author":"Kao Y. H.","year":"2005","journal-title":"Acta Paediatrica Taiwanica"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.7124\/bc.000090"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156\u2010013\u20100629\u20102"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.14734\/kjp.2013.24.4.315"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.10.19.20215398"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2005.02.009"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00708\u201013"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(66)80318\u20109"},{"key":"e_1_2_10_39_1","unstructured":"N.Basso M.Fonseca A.Garcia J.Zuardi M.Silva andH.Outani Enterovirus Isolation From Foetal and Placental Tissues: (No journal name provided; please confirm)."},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143\u20104004(91)90029\u2010f"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250\u2010200112000\u201000006"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.01.015"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20887"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2014.55.6.1562"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/inf.0000000000003821"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010002\u20100929\u20105"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2005.12.007"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13164922"},{"issue":"19","key":"e_1_2_10_49_1","first-page":"1046","article-title":"Coxsackie B5 Virus as a Cause of Neonatal Encephalitis and Myocarditis","volume":"85","author":"McLean D. M.","year":"1961","journal-title":"Canadian Medical Association Journal"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(69)80112\u20105"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103476(76)80808\u20106"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250\u2010198003001\u201000004"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(86)90102\u2010x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.239.135"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010005\u20100008\u20109"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006\u20100780"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163\u20104453(92)92798\u2010n"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890390405"},{"issue":"5","key":"e_1_2_10_59_1","first-page":"487","article-title":"Waterborne Viruses Associated With Repeated Abortion","volume":"76","author":"El\u2010Esnawy N. A.","year":"2000","journal-title":"Journal of the Egyptian Public Health Association"},{"issue":"7","key":"e_1_2_10_60_1","first-page":"1020","article-title":"Investigation of Viral Pathogens Contributing to Habitual Abortion","volume":"26","author":"Jiang W. L.","year":"2006","journal-title":"Journal of Southern Medical University"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3233\/hab\u2010240005"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/1064744042000210357"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.08.028"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(70)90058\u2010x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010019\u20102130\u20108"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2014.06.022"},{"key":"e_1_2_10_67_1","first-page":"140","article-title":"Viral Infections of the Fetus and Newborn","volume":"2","author":"Kibrick S.","year":"1961","journal-title":"Perspectives in Virology"},{"issue":"2","key":"e_1_2_10_68_1","first-page":"147","article-title":"Cardiovascular Effects of Congenital Infections","volume":"1","author":"Rosenberg H. S.","year":"1987","journal-title":"American Journal of Cardiovascular Pathology"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1967.03120030087016"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf02336555"},{"issue":"1","key":"e_1_2_10_71_1","first-page":"68","article-title":"The Role of Prenatal Coxsackievirus Infection in the Aetiology of Congenital Heart Defects in Children","volume":"29","author":"Koro\u2019lkova E. L.","year":"1989","journal-title":"Kardiologiia"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10437"},{"issue":"1","key":"e_1_2_10_73_1","article-title":"Congenital Enterovirus Infection Case Series: Early Recognition can Improve Outcome","volume":"17","author":"Arthur J.","year":"2021","journal-title":"Infant"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246\u2010021\u201002805\u20109"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2191"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.76.1.64"},{"issue":"11","key":"e_1_2_10_77_1","first-page":"1090","article-title":"Liquefactive Necrosis in Coxsackie B Encephalitis","volume":"110","author":"Estes M. L.","year":"1986","journal-title":"Archives of Pathology and Laboratory Medicine"},{"issue":"7","key":"e_1_2_10_78_1","first-page":"383","article-title":"Nonpolio Enterovirus Infection in the Neonate and Young Infant","volume":"10","author":"Hawkes M. T.","year":"2005","journal-title":"Pediatrics and Child Health"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s150100070029"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010002\u20100958\u20100"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006\u20100554"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010540\u201075546\u20103_10"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.4.408"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00401772"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.6.652"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.2.364"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/271958"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010017\u20104492\u2010z"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz2433"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2018.1548281"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552\u20106909.1995.tb02548.x"},{"issue":"4","key":"e_1_2_10_92_1","first-page":"177","article-title":"Infezioni Virali Congenite, Perinatali E Neonatali","volume":"30","author":"Tremolada S.","year":"2008","journal-title":"La Pediatria Medica e Chirurgica"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.70144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmv.70144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.70144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T16:58:29Z","timestamp":1782406709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.70144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":91,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/rmv.70144"],"URL":"https:\/\/doi.org\/10.1002\/rmv.70144","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]},"assertion":[{"value":"2025-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70144"}}