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Its underlying mechanisms remain unclear, but clinical similarities with post\u2010dengue depression complicate differentiation. Therefore, we conducted a systematic review and meta\u2010analysis to identify and compare factors associated with post\u2010dengue fatigue and post\u2010dengue depression. We searched PubMed, Science Direct, Web of Science and Google Scholar databases until 6 June 2025, with an update performed on 31 December 2025. This systematic review was conducted according to PRISMA guidelines. Meta\u2010analyses were conducted to assess associations of demographic, biological, clinical, medical or psychosocial factors with post\u2010dengue fatigue and post\u2010dengue depression using pooled odds ratios (OR). The study protocol was registered in PROSPERO (CRD420250655004). Nine studies (2006\u20132023) covering 1470 patients were included. The systematic review identified 13 factors eligible for meta\u2010analysis: twelve factors for post\u2010dengue fatigue and one for post\u2010dengue depression. Among these factors, female sex (OR 1.69, 95% CI: 1.33\u20132.14), myalgia (OR 3.45, 95% CI: 2.10\u20135.69), and severe dengue (OR 4.02, 95% CI: 1.45\u201311.13), particularly dengue haemorrhagic fever (OR 1.53, 95% CI: 1.04\u20132.24), were associated with post\u2010dengue fatigue. No factor was associated with post\u2010dengue depression in the meta\u2010analysis. However, narrative synthesis revealed thrombocytopaenia as a shared factor of both outcomes. This study highlights risk profiles for post\u2010dengue fatigue syndrome and depression, with female sex, myalgia, and dengue severity specifically associated with fatigue, while thrombocytopaenia might indicate a shared pathway. These findings support targeted surveillance and management strategies for at\u2010risk patients and highlight the need for further research into post\u2010dengue depression mechanisms.<\/jats:p>","DOI":"10.1002\/rmv.70164","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:24:47Z","timestamp":1779305087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post\u2010Infectious Fatigue and Depression Following Dengue: A Systematic Review and Meta\u2010Analysis of Associated Factors"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9903-4605","authenticated-orcid":false,"given":"Anna","family":"Cond\u00e9","sequence":"first","affiliation":[{"name":"Clinical Investigation Center INSERM CIC 1410 CHU R\u00e9union  Saint\u2010Pierre Reunion 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Medicine and Health UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"The Kirby Institute UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"G\u00e9rardin","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center INSERM CIC 1410 CHU R\u00e9union  Saint\u2010Pierre Reunion 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