{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:53:10Z","timestamp":1791287590625,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014337","name":"FURTHERMORE grants in publishing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and is responsible for anogenital warts and several cancers. Although the effectiveness of female HPV vaccination has been well established since its introduction in 2006, no systematic review has specifically evaluated the impact of male vaccination programs introduced in 2011. We synthesised real\u2010world evidence on gender\u2010neutral vaccination (GNV), identifying 17 studies reporting rates of HPV infection, anogenital warts, and HPV\u2010related cancers during the pre\u2010 and post\u2010GNV periods among males in high\u2010income countries. Overall, we found limited but consistent evidence of benefit in males, although some of the observed reductions may also reflect herd immunity effects from earlier female\u2010only HPV vaccination programs. Only two studies evaluated temporal trends in HPV infection, both demonstrating reductions in vaccine\u2010targeted genotypes, although important methodological limitations restrict generalisability. Eight studies reported consistent declines in anogenital warts among adolescents and young adults, supporting a beneficial population\u2010level impact of GNV. Analyses of HPV\u2010related cancers showed an overall increasing incidence, likely reflecting long latency periods. However, some studies reported encouraging declines in cancer incidence among younger age groups. Oropharyngeal incidence decreased by 11%\u201319% among U.S. males aged 20\u201344\u00a0years, and penile cancer incidence decreased by 6%\u201338% among those aged 15\u201334\u00a0years. In Texas, penile and anal cancer incidence decreased by 35% and 16%, respectively, among males 20\u00a0years or older, while in Austria, anal cancer incidence decreased by 38% among men aged 30\u201339\u00a0years. Given the relatively recent introduction of male vaccination programs, longer follow\u2010up is required to fully assess their impact. Studies in low\u2010 and middle\u2010income countries are urgently needed.<\/jats:p>","DOI":"10.1002\/rmv.70171","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T19:13:42Z","timestamp":1780168422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Male Human Papillomavirus (HPV) Vaccination on HPV Infection and HPV\u2010Related Diseases: A Systematic Review"],"prefix":"10.1002","volume":"36","author":[{"given":"Anna","family":"Beltrame","sequence":"first","affiliation":[{"name":"Center for Immunization and Infection Research in Cancer (CIIRC) H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Racheal S.","family":"Dube Mandishora","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostic &amp; Investigative Sciences University of Zimbabwe Medical Microbiology Unit  Harare Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei (Vivian)","family":"Wang","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc.  Rahway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Fan","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Shared Resource H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Katherine","family":"Haver","sequence":"additional","affiliation":[{"name":"Biomedical Library H. 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