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Increasing evidence suggests that environmental factors may critically influence these virus\u2010host interactions. Among such factors, airborne microplastics (MPs) have gained attention because of their ability to accumulate within the respiratory tract, disrupt epithelial barrier integrity, impair antiviral immune responses, and induce chronic oxidative and inflammatory stress. This review suggests a \u2018double\u2010hit\u2019 hypothesis in which inhaled MPs act as environmental cofactors that enhance susceptibility to oncogenic viruses and facilitate virus\u2010associated pulmonary pathology. MPs may affect viral adsorption, airway deposition, epithelial infectivity, and long\u2010term persistence while simultaneously weakening mucosal immune surveillance and interferon\u2010mediated antiviral defenses. These effects may create a permissive pulmonary microenvironment that supports persistent infection by candidate oncogenic viruses, including human papillomavirus (HPV), Epstein\u2010Barr virus (EBV), Merkel cell polyomavirus (MCPyV), and other potentially tumour\u2010promoting viruses. Convergent activation of pathways related to oxidative stress, NF\u2010\u03baB signalling, inflammasome activation, epithelial\u2010mesenchymal transition, and defective tissue repair may amplify chronic airway inflammation, accelerate asthma progression, and promote malignant transformation. Although direct clinical evidence remains limited, accumulating mechanistic and experimental findings support a biologically plausible interaction between airborne microplastics and oncogenic viruses. We highlight key knowledge gaps regarding viral persistence, MP\u2010mediated modulation of antiviral immunity, virus\u2010particle interactions, and biomarkers of environmentally driven viral carcinogenesis. Improved understanding of these interactions may provide new insights into the virological basis of chronic airway disease and lung cancer development.<\/jats:p>","DOI":"10.1002\/rmv.70181","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:02:04Z","timestamp":1783425724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oncogenic Viruses and Inhaled Microplastics: A Double Hit Hypothesis for Asthma Progression and Lung Cancer Development"],"prefix":"10.1002","volume":"36","author":[{"given":"Jiacheng","family":"Yin","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzhe","family":"Su","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing 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