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The viral aetiology of NPC provides a strong biological rationale for immune\u2010based treatment; however, translation of chimaeric antigen receptor (CAR) T\u2010cell therapy into this solid tumour setting is constrained by poor tumour trafficking, antigen heterogeneity, limited surface accessibility of EBV latent antigens, T\u2010cell exhaustion, and an immunosuppressive tumour microenvironment. This review critically evaluates the emerging therapeutic prospects of CRISPR\u2010engineered CAR\u2010T cell therapy for EBV\u2010associated NPC. It synthesises evidence on EBV latency biology, NPC immune evasion, solid\u2010tumour CAR\u2010T limitations, and genome\u2010engineering strategies including conventional CRISPR\u2010Cas9, base editing, prime editing, and double\u2010strand\u2010break\u2010sparing targeted integration. Particular attention is given to genotoxicity, chromosomal rearrangements, chromosome loss, bystander and off\u2010target editing, manufacturing heterogeneity, and the regulatory and biological barriers that currently separate technical feasibility from NPC\u2010specific clinical implementation. Available clinical evidence from checkpoint blockade, EBV\u2010specific adoptive T\u2010cell therapy, base\u2010edited CAR\u2010T cells in haematologic malignancy, and early CRISPR\u2010edited T\u2010cell trials supports the feasibility of immune and genetic redirection but does not establish efficacy of a clinically validated CRISPR\u2010engineered CAR\u2010T platform for NPC. Future development should prioritise surface\u2010accessible antigen validation, fit\u2010for\u2010purpose selection of editing technology, genomic safety, scalable manufacturing, and biomarker\u2010driven early\u2010phase trials.<\/jats:p>","DOI":"10.1002\/rmv.70199","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:46:07Z","timestamp":1788630367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CRISPR\u2010Engineered CAR\u2010T Cell Therapy for Epstein\u2013Barr Virus\u2010Associated Nasopharyngeal Carcinoma: A Review of Emerging Therapeutic Prospects"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7482-3402","authenticated-orcid":false,"given":"Noor","family":"Allehyani","sequence":"first","affiliation":[{"name":"Department of Medical Laboratories College of Applied Medical Sciences Shaqra University  Shaqra Saudi 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