{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:45:50Z","timestamp":1791996350985,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007487","name":"Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico","doi-asserted-by":"publisher","award":["CCYC\u20102023\u2010IMP\u201008"],"award-info":[{"award-number":["CCYC\u20102023\u2010IMP\u201008"]}],"id":[{"id":"10.13039\/501100007487","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dengue remains a major public health concern in Mexico, with incidence and clinical burden increasing substantially in recent years. Using national surveillance data from 2020 to 2024, this study provides a comprehensive overview of the changing epidemiological landscape, with an emphasis on geographic distribution, temporal trends, serotype dynamics, and disease severity. Over this period, Mexico saw an almost fivefold increase in dengue cases, reaching over 123,000 confirmed infections and 426 deaths in 2024, the highest annual number recorded. Seasonal patterns shifted, with sustained transmission extending into unusual winter months from late 2023. Serotyping data revealed a shift in predominant virus serotypes, with DENV2 predominating until 2022, DENV1 peaking in 2021, and DENV3 rising sharply from 2022 onward, becoming dominant in 2023 and almost exclusive by 2024. This shift coincided with a sustained rise in dengue with warning signs (from 16.9% in 2020 to\u00a0&gt;\u00a042% in 2023\u20132024) and higher hospitalisation rates, while severe dengue remained below 5%. Although DENV3 dominated nationally, DENV1 and DENV2 persisted in specific states, and DENV4 circulated sporadically, particularly in southern and northern regions. Several traditionally low\u2010prevalence states experienced atypical outbreaks, underscoring the potential for sudden epidemic expansion. Climatic analysis showed a consistent positive association between temperature and DENV3 prevalence, with precipitation effects varying by year. Odds ratio analysis suggested serotype\u2010specific differences in severity across years. These findings underscore the heterogeneous and dynamic nature of dengue transmission in Mexico and highlight the need for regional surveillance, prevention, and clinical preparedness strategies.<\/jats:p>","DOI":"10.1002\/rmv.70216","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:20:47Z","timestamp":1791408047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional and Temporal Dynamics of Dengue in Mexico (2020\u20132024): A Comprehensive Epidemiological Analysis"],"prefix":"10.1002","volume":"36","author":[{"given":"Blanca","family":"Taboada","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica del Desarrollo y Fisiolog\u00eda Molecular Instituto de Biotecnolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"Z\u00e1rate","sequence":"additional","affiliation":[{"name":"Posgrado en Ciencias Gen\u00f3micas Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"D\u00edaz\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias Universidad Aut\u00f3noma del Estado de Morelos  Cuernavaca Morelos M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Hurtado","sequence":"additional","affiliation":[{"name":"Unidad de Computo Instituto de Biotecnolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6803098"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00705\u2010013\u20101645\u20103"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.884645"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41564\u2010019\u20100476\u20108"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.HELIYON.2023.E20069"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PNTD.0009359"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/JTM\/TAAB146"},{"key":"e_1_2_18_9_1","unstructured":"Dengue and Severe Dengue. (2024) accessed May 29 2025 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/dengue\u2010and\u2010severe\u2010dengue."},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12942\u2010020\u201000241\u20101"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.4269\/AJTMH.21\u20100409"},{"key":"e_1_2_18_12_1","unstructured":"Gobierno.Panorama Epidemiol\u00f3gico de Dengue 2024 Secretar\u00eda de Salud. (2025) accessed May 29 2025 https:\/\/www.gob.mx\/salud\/documentos\/panorama\u2010epidemiologico\u2010de\u2010dengue\u20102024."},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PNTD.0003547"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PNTD.0006938"},{"key":"e_1_2_18_15_1","unstructured":"Direcci\u00f3n General de Epidemiolog\u00eda \u201cManual de procedimientos estandarizados para la vigilancia epidemiol\u00f3gica de las enfermedades transmitias por vector \u201d (2021) accessed March 21 2026 https:\/\/epidemiologia.salud.gob.mx\/gobmx\/salud\/documentos\/manuales\/36_Manual_ETV.pdf."},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCV.2025.105763"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/TMI.14095"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PNTD.0006817"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13071\u2010021\u201004631\u20107"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PNTD.0012811"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects14010049"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10584\u2010016\u20101679\u20100"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(19)30161\u20106"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13071\u2010024\u201006598\u20107"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13030202"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/S41182\u2010024\u201000620\u20105"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.3201\/EID3002.231615"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/VE\/VEAF034"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PNTD.0011169"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.70216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmv.70216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.70216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:57:17Z","timestamp":1791993437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.70216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/rmv.70216"],"URL":"https:\/\/doi.org\/10.1002\/rmv.70216","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2025-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70216"}}