{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:05:06Z","timestamp":1790424306198,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":1163,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009425","name":"Landsteiner Foundation for Blood Transfusion Research","doi-asserted-by":"publisher","award":["LSBR\u20101244"],"award-info":[{"award-number":["LSBR\u20101244"]}],"id":[{"id":"10.13039\/100009425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009425","name":"Landsteiner Foundation for Blood Transfusion Research","doi-asserted-by":"publisher","award":["LSBR\u20101707"],"award-info":[{"award-number":["LSBR\u20101707"]}],"id":[{"id":"10.13039\/100009425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008594","name":"European Hematology Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1002\/rth2.12242","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T09:32:16Z","timestamp":1564651936000},"page":"718-732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Alternative trafficking of Weibel\u2010Palade body proteins in CRISPR\/Cas9\u2010engineered von Willebrand factor\u2013deficient blood outgrowth endothelial cells"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-9667","authenticated-orcid":false,"given":"Maaike","family":"Schillemans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4184-6171","authenticated-orcid":false,"given":"Marije","family":"Kat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurjen","family":"Westeneng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Gangaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno","family":"Hofman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Nota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris P.J.","family":"van Alphen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje","family":"van den Biggelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coert","family":"Margadant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Voorberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1205-9689","authenticated-orcid":false,"given":"Ruben","family":"Bierings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/rth2.12242_bb0010","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.biochem.67.1.395","article-title":"Biochemistry and genetics of von Willebrand factor","volume":"67","author":"Sadler","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"10.1002\/rth2.12242_bb0015","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1056\/NEJMra1601561","article-title":"Von Willebrand's disease","volume":"375","author":"Leebeek","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1002\/rth2.12242_bb0020","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1111\/j.1538-7836.2005.01369.x","article-title":"von Willebrand factor: two sides of a coin","volume":"3","author":"Sadler","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1002\/rth2.12242_bb0025","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1161\/01.ATV.0000209501.56852.6c","article-title":"Dynamics and plasticity of Weibel\u2010Palade bodies in endothelial cells","volume":"26","author":"Rondaij","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1002\/rth2.12242_bb0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1242\/jcs.03494","article-title":"Formation and function of Weibel\u2010Palade bodies","volume":"121","author":"Metcalf","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1002\/rth2.12242_bb0035","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/jth.14322","article-title":"Exocytosis of Weibel\u2010Palade bodies: how to unpack a vascular emergency kit","volume":"17","author":"Schillemans","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.1002\/rth2.12242_bb0040","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1111\/jth.13112","article-title":"Angiogenic characteristics of blood outgrowth endothelial cells from patients with von Willebrand disease","volume":"13","author":"Groeneveld","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1002\/rth2.12242_bb0045","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1073\/pnas.061307098","article-title":"Defect in regulated secretion of P\u2010selectin affects leukocyte recruitment in von Willebrand factor\u2010deficient mice","volume":"98","author":"Denis","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/rth2.12242_bb0050","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1182\/blood-2004-02-0464","article-title":"Re\u2010establishment of VWF\u2010dependent Weibel\u2010Palade bodies in VWD endothelial cells","volume":"105","author":"Haberichter","year":"2005","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0055","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1182\/blood-2005-09-3605","article-title":"Phenotypic correction of von Willebrand disease type 3 blood\u2010derived endothelial cells with lentiviral vectors expressing von Willebrand factor","volume":"107","author":"De Meyer","year":"2006","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0060","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0092-8674(91)90648-I","article-title":"Induction of specific storage organelles by von Willebrand factor propolypeptide","volume":"64","author":"Wagner","year":"1991","journal-title":"Cell"},{"key":"10.1002\/rth2.12242_bb0065","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/j.1460-2075.1993.tb05709.x","article-title":"Biogenesis of von Willebrand factor\u2013containing organelles in heterologous transfected CV\u20101 cells","volume":"12","author":"Voorberg","year":"1993","journal-title":"EMBO J"},{"key":"10.1002\/rth2.12242_bb0070","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.devcel.2005.12.012","article-title":"The physiological function of von Willebrand's factor depends on its tubular storage in endothelial Weibel\u2010Palade bodies","volume":"10","author":"Michaux","year":"2006","journal-title":"Dev Cell"},{"key":"10.1002\/rth2.12242_bb0075","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1182\/blood.V96.10.3322","article-title":"Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins","volume":"96","author":"Andr\u00e9","year":"2000","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0080","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1182\/blood-2002-05-1401","article-title":"ADAMTS\u201013 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions","volume":"100","author":"Dong","year":"2002","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0085","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1038\/ncomms8858","article-title":"Flow\u2010driven assembly of VWF fibres and webs in in vitro microvessels","volume":"6","author":"Zheng","year":"2015","journal-title":"Nat Commun"},{"key":"10.1002\/rth2.12242_bb0090","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1182\/blood-2009-07-235150","article-title":"Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet\u2010decorated von Willebrand factor strings","volume":"115","author":"Bridges","year":"2010","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0095","doi-asserted-by":"crossref","first-page":"e0173077","DOI":"10.1371\/journal.pone.0173077","article-title":"Platelet\u2010independent adhesion of calcium\u2010loaded erythrocytes to von Willebrand factor","volume":"12","author":"Smeets","year":"2017","journal-title":"PLoS One"},{"key":"10.1002\/rth2.12242_bb0100","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1182\/blood-2010-03-276170","article-title":"A revised model for the secretion of tPA and cytokines from cultured endothelial cells","volume":"116","author":"Knipe","year":"2010","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0105","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1182\/blood-2010-11-321489","article-title":"CD63 is an essential cofactor to leukocyte recruitment by endothelial P\u2010selectin","volume":"118","author":"Doyle","year":"2011","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0110","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1038\/ncomms4738","article-title":"Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63","volume":"5","author":"Poeter","year":"2014","journal-title":"Nat Commun"},{"key":"10.1002\/rth2.12242_bb0115","doi-asserted-by":"crossref","first-page":"9524","DOI":"10.1073\/pnas.95.16.9524","article-title":"A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis","volume":"95","author":"Denis","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/rth2.12242_bb0120","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1182\/blood-2003-10-3685","article-title":"The Tie\u20102 ligand angiopoietin\u20102 is stored in and rapidly released upon stimulation from endothelial cell Weibel\u2010Palade bodies","volume":"103","author":"Fiedler","year":"2004","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0125","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1021\/pr300010r","article-title":"Proteomic screen identifies IGFBP7 as a novel component of endothelial cell\u2013specific Weibel\u2010Palade bodies","volume":"11","author":"van Breevoort","year":"2012","journal-title":"J Proteome Res"},{"key":"10.1002\/rth2.12242_bb0130","doi-asserted-by":"crossref","first-page":"e38399","DOI":"10.1371\/journal.pone.0038399","article-title":"The shear stress\u2010induced transcription factor KLF2 affects dynamics and angiopoietin\u20102 content of Weibel\u2010Palade bodies","volume":"7","author":"van Agtmaal","year":"2012","journal-title":"PLoS One"},{"key":"10.1002\/rth2.12242_bb0135","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1182\/blood-2010-01-264507","article-title":"Endothelial von Willebrand factor regulates angiogenesis","volume":"117","author":"Starke","year":"2011","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0140","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/bjh.12272","article-title":"Von Willebrand disease\u2010associated angiodysplasia: a few answers, still many questions","volume":"161","author":"Franchini","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1002\/rth2.12242_bb0145","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1182\/blood-2018-01-769018","article-title":"Von Willebrand factor regulation of blood vessel formation","volume":"132","author":"Randi","year":"2018","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0150","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1182\/blood-2012-06-435727","article-title":"Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells","volume":"121","author":"Starke","year":"2013","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0155","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/MBC.0000000000000635","article-title":"Abnormal angiogenesis in blood outgrowth endothelial cells derived from von Willebrand disease patients","volume":"28","author":"Selvam","year":"2017","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1002\/rth2.12242_bb0160","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1182\/asheducation-2013.1.254","article-title":"von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy","volume":"2013","author":"Lillicrap","year":"2013","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1002\/rth2.12242_bb0165","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/CIRCRESAHA.117.306290","article-title":"Efficient gene disruption in cultured primary human endothelial cells by CRISPR\/Cas9","volume":"117","author":"Abrahimi","year":"2015","journal-title":"Circ Res"},{"key":"10.1002\/rth2.12242_bb0170","doi-asserted-by":"crossref","first-page":"42127","DOI":"10.1038\/srep42127","article-title":"Method for dual viral vector mediated CRISPR\u2010Cas9 gene disruption in primary human endothelial cells","volume":"7","author":"Gong","year":"2017","journal-title":"Sci Rep"},{"key":"10.1002\/rth2.12242_bb0175","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1538-7836.2008.03192.x","article-title":"Blood outgrowth endothelial cells from cord blood and peripheral blood: angiogenesis\u2010related characteristics in vitro","volume":"7","author":"van Beem","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1002\/rth2.12242_bb0180","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1038\/nprot.2012.093","article-title":"Establishment of outgrowth endothelial cells from peripheral blood","volume":"7","author":"Martin\u2010Ramirez","year":"2012","journal-title":"Nat Protoc"},{"key":"10.1002\/rth2.12242_bb0185","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1182\/blood-2013-10-535831","article-title":"STXBP1 promotes Weibel\u2010Palade body exocytosis through its interaction with the Rab27A effector Slp4\u2010a","volume":"123","author":"van Breevoort","year":"2014","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0190","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nbt.2647","article-title":"DNA targeting specificity of RNA\u2010guided Cas9 nucleases","volume":"31","author":"Hsu","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1002\/rth2.12242_bb0195","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off\u2010target effects of CRISPR\u2010Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat Biotechnol"},{"key":"10.1002\/rth2.12242_bb0200","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome\u2010wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat Methods"},{"key":"10.1002\/rth2.12242_bb0205","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1161\/ATVBAHA.117.310701","article-title":"Weibel\u2010Palade body localized syntaxin\u20103 modulates von Willebrand factor secretion from endothelial cells","volume":"38","author":"Schillemans","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1002\/rth2.12242_bb0210","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/jth.12460","article-title":"Phosphatidylinositol\u20103,4,5\u2010triphosphate\u2010dependent Rac exchange factor 1 regulates epinephrine\u2010induced exocytosis of Weibel\u2010Palade bodies","volume":"12","author":"van Hooren","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1002\/rth2.12242_bb0215","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/s41590-018-0155-6","article-title":"Translational repression of pre\u2010formed cytokine\u2010encoding mRNA prevents chronic activation of memory T cells","volume":"19","author":"Salerno","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1002\/rth2.12242_bb0220","doi-asserted-by":"crossref","first-page":"9759735","DOI":"10.1155\/2017\/9759735","article-title":"Markers and biomarkers of endothelium: when something is rotten in the state","volume":"2017","author":"Goncharov","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"10.1002\/rth2.12242_bb0225","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1084\/jem.188.9.1751","article-title":"Rapid secretion of prestored interleukin 8 from Weibel\u2010Palade bodies of microvascular endothelial cells","volume":"188","author":"Utgaard","year":"1998","journal-title":"J Exp Med"},{"key":"10.1002\/rth2.12242_bb0230","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.188.9.1757","article-title":"Endothelial cell \u201cmemory\u201d of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel\u2010Palade bodies","volume":"188","author":"Wolff","year":"1998","journal-title":"J Exp Med"},{"key":"10.1002\/rth2.12242_bb0235","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1111\/j.1538-7836.2007.02768.x","article-title":"Efficiency of von Willebrand factor\u2013mediated targeting of interleukin\u20108 into Weibel\u2010Palade bodies","volume":"5","author":"Bierings","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1002\/rth2.12242_bb0240","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1242\/jcs.073593","article-title":"Protein mobilities and P\u2010selectin storage in Weibel\u2010Palade bodies","volume":"123","author":"Kiskin","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1002\/rth2.12242_bb0245","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1182\/blood.V118.21.698.698","article-title":"Von Willebrand factor binds to the endothelial growth factor angiopoietin\u20102 both within endothelial cells and upon release from Weibel Palade bodies","volume":"118","author":"McKinnon","year":"2011","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0250","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1182\/blood.V82.4.1184.1184","article-title":"CD63 is a component of Weibel\u2010Palade bodies of human endothelial cells","volume":"82","author":"Vischer","year":"1993","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0255","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1091\/mbc.11.5.1829","article-title":"The tetraspanin CD63\/lamp3 cycles between endocytic and secretory compartments in human endothelial cells","volume":"11","author":"Kobayashi","year":"2000","journal-title":"Mol Biol Cell"},{"key":"10.1002\/rth2.12242_bb0260","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1600-0854.2006.00415.x","article-title":"P\u2010selectin and CD63 use different mechanisms for delivery to Weibel\u2010Palade bodies","volume":"7","author":"Harrison\u2010Lavoie","year":"2006","journal-title":"Traffic"},{"key":"10.1002\/rth2.12242_bb0265","doi-asserted-by":"crossref","DOI":"10.3324\/haematol.2018.207787","article-title":"Defective AP\u20103\u2010dependent VAMP8 trafficking impairs Weibel\u2010Palade body exocytosis in Hermansky\u2010Pudlak syndrome type 2 blood outgrowth endothelial cells","author":"Karampini","year":"2019","journal-title":"Haematologica"},{"key":"10.1002\/rth2.12242_bb0270","doi-asserted-by":"crossref","first-page":"9184","DOI":"10.1002\/jcp.27595","article-title":"Genome\u2010wide CRISPR\u2010Cas9 viability screen reveals genes involved in TNF\u2010\u03b1\u2010induced apoptosis of human umbilical vein endothelial cells","volume":"234","author":"Cai","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1002\/rth2.12242_bb0275","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1182\/blood-2004-04-1396","article-title":"Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood","volume":"104","author":"Ingram","year":"2004","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0280","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1161\/ATVBAHA.117.309962","article-title":"Differentiation, evaluation, and application of human induced pluripotent stem cell\u2010derived endothelial cells","volume":"37","author":"Lin","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1002\/rth2.12242_bb0285","first-page":"431","article-title":"Genome editing in induced pluripotent stem cells","volume":"17","author":"Cheng","year":"2012","journal-title":"Genes Cells Stem Cell Rev Rep"},{"key":"10.1002\/rth2.12242_bb0290","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1182\/blood-2010-03-276311","article-title":"von Willebrand factor promotes leukocyte extravasation","volume":"116","author":"Petri","year":"2010","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0295","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/cvr\/cvp241","article-title":"Interleukin 8 and cardiovascular disease","volume":"84","author":"Apostolakis","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1002\/rth2.12242_bb0300","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1182\/blood.V98.5.1424","article-title":"Localized reduction of atherosclerosis in von Willebrand factor\u2013deficient mice","volume":"98","author":"Methia","year":"2001","journal-title":"Blood"},{"key":"10.1002\/rth2.12242_bb0305","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/jth.12456","article-title":"ADAMTS13 modulates atherosclerotic plaque progression in mice via a VWF\u2010dependent mechanism","volume":"12","author":"Gandhi","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1002\/rth2.12242_bb0310","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/ATVBAHA.117.309918","article-title":"Endothelial cell\u2013derived von Willebrand factor, but not platelet\u2010derived, promotes atherosclerosis in apolipoprotein E\u2013deficient mice","volume":"38","author":"Doddapattar","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1002\/rth2.12242_bb0315","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.blre.2012.05.002","article-title":"Von Willebrand factor deficiency and atherosclerosis","volume":"26","author":"van Galen","year":"2012","journal-title":"Blood Rev"},{"key":"10.1002\/rth2.12242_bb0320","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1160\/TH17-06-0397","article-title":"Circulating angiogenic mediators in patients with moderate and severe von Willebrand disease: a multicentre cross\u2010sectional study","volume":"118","author":"Groeneveld","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1002\/rth2.12242_bb0325","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1172\/JCI58832","article-title":"Angiopoietin\u20102 differentially regulates angiogenesis through TIE2 and integrin signaling","volume":"122","author":"Felcht","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1002\/rth2.12242_bb0330","doi-asserted-by":"crossref","first-page":"23842","DOI":"10.1074\/jbc.M109.097543","article-title":"Angiopoietin\u20102 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation","volume":"285","author":"Thomas","year":"2010","journal-title":"J Biol Chem"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frth2.12242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rth2.12242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rth2.12242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037922017939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037922017939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rth2.12242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:17:03Z","timestamp":1762863423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037922017939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S2475037922017939"],"URL":"https:\/\/doi.org\/10.1002\/rth2.12242","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alternative trafficking of Weibel\u2010Palade body proteins in CRISPR\/Cas9\u2010engineered von Willebrand factor\u2013deficient blood outgrowth endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1002\/rth2.12242","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 The Authors. Research and Practice in Thrombosis and Haemostasis published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis","name":"copyright","label":"Copyright"}]}}