{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:27:16Z","timestamp":1781738836569,"version":"3.54.5"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":908,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1002\/rth2.12369","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T14:08:38Z","timestamp":1591106918000},"page":"813-822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Measuring beta\u2010galactose exposure on platelets: Standardization and healthy reference values"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-0263","authenticated-orcid":false,"given":"Dominique","family":"Lasne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Pascreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadyo","family":"Darame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Charlotte","family":"Bourrienne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Tournoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Philippe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ziachahabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-9052","authenticated-orcid":false,"given":"Felipe","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambroise","family":"Marcais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5152-9156","authenticated-orcid":false,"given":"C\u00e9cile V.","family":"Denis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-8114","authenticated-orcid":false,"given":"Alexandre","family":"Kauskot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8847-8935","authenticated-orcid":false,"given":"Delphine","family":"Borgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1002\/rth2.12369_bb0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1034\/j.1600-0609.2000.90072.x","article-title":"Indirect study of thrombopoiesis (TPO, reticulated platelets, glycocalicin) in patients with hereditary macrothrombocytopenia","volume":"64","author":"Fabris","year":"2000","journal-title":"Eur J Haematol"},{"issue":"8","key":"10.1002\/rth2.12369_bb0015","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1182\/blood-2009-01-199414","article-title":"Role of sialic acid for platelet life span: exposure of beta\u2010galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor\u2010expressing liver macrophages and hepatocytes","volume":"114","author":"Sorensen","year":"2009","journal-title":"Blood"},{"issue":"Suppl 1","key":"10.1002\/rth2.12369_bb0020","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1538-7836.2011.04276.x","article-title":"The role of lectins and glycans in platelet clearance","volume":"9","author":"Hoffmeister","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"1","key":"10.1002\/rth2.12369_bb0025","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nm.3770","article-title":"The Ashwell\u2010Morell receptor regulates hepatic thrombopoietin production via JAK2\u2010STAT3 signaling","volume":"21","author":"Grozovsky","year":"2015","journal-title":"Nat Med"},{"issue":"31","key":"10.1002\/rth2.12369_bb0030","doi-asserted-by":"crossref","first-page":"8360","DOI":"10.1073\/pnas.1707662114","article-title":"Sialylation on O\u2010glycans protects platelets from clearance by liver Kupffer cells","volume":"114","author":"Li","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1002\/rth2.12369_bb0035","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190723","article-title":"Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets","volume":"217","author":"Deppermann","year":"2020","journal-title":"J Exp Med"},{"issue":"17","key":"10.1002\/rth2.12369_bb0040","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1182\/blood-2018-04-847798","article-title":"Mutation in GNE is associated with a severe form of congenital thrombocytopenia","volume":"132","author":"Futterer","year":"2018","journal-title":"Blood"},{"issue":"12","key":"10.1002\/rth2.12369_bb0045","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.nmd.2014.07.008","article-title":"GNE myopathy associated with congenital thrombocytopenia: a report of two siblings","volume":"24","author":"Izumi","year":"2014","journal-title":"Neuromuscul Disord"},{"issue":"12","key":"10.1002\/rth2.12369_bb0050","doi-asserted-by":"crossref","first-page":"e613","DOI":"10.3324\/haematol.2018.198028","article-title":"A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation","volume":"103","author":"Kauskot","year":"2018","journal-title":"Haematologica"},{"issue":"7","key":"10.1002\/rth2.12369_bb0055","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1212\/WNL.0b013e3182a08f53","article-title":"Intellectual disability and bleeding diathesis due to deficient CMP\u2013sialic acid transport","volume":"81","author":"Mohamed","year":"2013","journal-title":"Neurology"},{"issue":"11","key":"10.1002\/rth2.12369_bb0060","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1002\/ajmg.a.38412","article-title":"Encephalopathy caused by novel mutations in the CMP\u2010sialic acid transporter, SLC35A1","volume":"173","author":"Ng","year":"2017","journal-title":"Am J Med Genet A"},{"issue":"17","key":"10.1002\/rth2.12369_bb0065","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1182\/blood-2018-04-845545","article-title":"GNE variants causing autosomal recessive macrothrombocytopenia without associated muscle wasting","volume":"132","author":"Revel\u2010Vilk","year":"2018","journal-title":"Blood"},{"issue":"3","key":"10.1002\/rth2.12369_bb0070","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1182\/blood.V97.3.826","article-title":"Macrothrombocytopenia with abnormal demarcation membranes in megakaryocytes and neutropenia with a complete lack of sialyl\u2010Lewis\u2010X antigen in leukocytes\u2013a new syndrome?","volume":"97","author":"Willig","year":"2001","journal-title":"Blood"},{"issue":"1","key":"10.1002\/rth2.12369_bb0075","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13045-017-0476-1","article-title":"Platelet desialylation is a novel mechanism and a therapeutic target in thrombocytopenia during sepsis: an open\u2010label, multicenter, randomized controlled trial","volume":"10","author":"Li","year":"2017","journal-title":"J Hematol Oncol"},{"issue":"4","key":"10.1002\/rth2.12369_bb0080","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.3324\/haematol.2013.102897","article-title":"Severe platelet desialylation in a patient with glycoprotein Ib\/IX antibody\u2010mediated immune thrombocytopenia and fatal pulmonary hemorrhage","volume":"99","author":"Li","year":"2014","journal-title":"Haematologica"},{"key":"10.1002\/rth2.12369_bb0085","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1038\/ncomms8737","article-title":"Desialylation is a mechanism of Fc\u2010independent platelet clearance and a therapeutic target in immune thrombocytopenia","volume":"6","author":"Li","year":"2015","journal-title":"Nat Commun"},{"issue":"5","key":"10.1002\/rth2.12369_bb0090","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3109\/09537104.2014.948838","article-title":"Successful treatment with oseltamivir phosphate in a patient with chronic immune thrombocytopenia positive for anti\u2010GPIb\/IX autoantibody","volume":"26","author":"Shao","year":"2015","journal-title":"Platelets"},{"issue":"1","key":"10.1002\/rth2.12369_bb0095","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13045-017-0413-3","article-title":"Platelet desialylation correlates with efficacy of first\u2010line therapies for immune thrombocytopenia","volume":"10","author":"Tao","year":"2017","journal-title":"J Hematol Oncol"},{"issue":"2\u20134","key":"10.1002\/rth2.12369_bb0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000321379","article-title":"An experience of oseltamivir phosphate (Tamiflu) in a pediatric patient with chronic idiopathic thrombocytopenic purpura: a case report","volume":"37","author":"Alioglu","year":"2010","journal-title":"Pathophysiol Haemost Thromb"},{"key":"10.1002\/rth2.12369_bb0105","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13045-015-0216-3","article-title":"Desialylation is associated with apoptosis and phagocytosis of platelets in patients with prolonged isolated thrombocytopenia after allo\u2010HSCT","volume":"8","author":"Zhang","year":"2015","journal-title":"J Hematol Oncol"},{"key":"10.1002\/rth2.12369_bb0110","doi-asserted-by":"crossref","DOI":"10.3324\/haematol.2019.236117","article-title":"Autoantibody\u2010mediated desialylation impairs human thrombopoiesis and platelet life span","author":"Marini","year":"2019","journal-title":"Haematologica"},{"issue":"3","key":"10.1002\/rth2.12369_bb0115","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/jth.14722","article-title":"Acquired Glanzmann thrombasthenia associated with platelet desialylation","volume":"18","author":"Zheng","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"6","key":"10.1002\/rth2.12369_bb0120","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1080\/09537104.2018.1513476","article-title":"Multirefractory primary immune thrombocytopenia; targeting the decreased sialic acid content","volume":"30","author":"Revilla","year":"2018","journal-title":"Platelets"},{"key":"10.1002\/rth2.12369_bb0125","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12863","article-title":"Platelet clearance via shear\u2010induced unfolding of a membrane mechanoreceptor","volume":"7","author":"Deng","year":"2016","journal-title":"Nat Commun"},{"issue":"12","key":"10.1002\/rth2.12369_bb0130","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.3324\/haematol.2018.206250","article-title":"Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease: preclinical and clinical evidence","volume":"104","author":"Dupont","year":"2019","journal-title":"Haematologica"},{"key":"10.1002\/rth2.12369_bb0135","volume":"28","author":"Horowitz","year":"2010"},{"key":"10.1002\/rth2.12369_bb0140","series-title":"WHO Expert committee on biological standardization","first-page":"107","year":"2002"},{"issue":"3","key":"10.1002\/rth2.12369_bb0145","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1423-0410.1968.tb01749.x","article-title":"The specificity of the haemagglutinin of the Castor bean, Ricinus communis","volume":"15","author":"Drysdale","year":"1968","journal-title":"Vox Sang"},{"key":"10.1002\/rth2.12369_bb0150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2105-7-123","article-title":"Detecting outliers when fitting data with nonlinear regression \u2010 a new method based on robust nonlinear regression and the false discovery rate","volume":"7","author":"Motulsky","year":"2006","journal-title":"BMC Bioinformatics"},{"issue":"10","key":"10.1002\/rth2.12369_bb0155","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/jemt.22407","article-title":"New sensitive detection method for lectin hemagglutination using microscopy","volume":"77","author":"Adamova","year":"2014","journal-title":"Microsc Res Tech"},{"issue":"4","key":"10.1002\/rth2.12369_bb0160","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/09537104.2010.547959","article-title":"Glycoprotein IIb\u2010IIIa content and platelet aggregation in healthy volunteers and patients with acute coronary syndrome","volume":"22","author":"Yakushkin","year":"2011","journal-title":"Platelets"},{"issue":"1","key":"10.1002\/rth2.12369_bb0165","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0092-8674(02)01253-9","article-title":"The clearance mechanism of chilled blood platelets","volume":"112","author":"Hoffmeister","year":"2003","journal-title":"Cell"},{"issue":"5","key":"10.1002\/rth2.12369_bb0170","first-page":"561","article-title":"[Determination of full blood count normal reference values for adults in France]","volume":"72","author":"Troussard","year":"2014","journal-title":"Ann Biol Clin"},{"issue":"1","key":"10.1002\/rth2.12369_bb0175","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1038\/s41598-018-38086-1","article-title":"Multiple concomitant mechanisms contribute to low platelet count in patients with immune thrombocytopenia","volume":"9","author":"Grodzielski","year":"2019","journal-title":"Sci Rep"},{"issue":"11","key":"10.1002\/rth2.12369_bb0180","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/nm.2030","article-title":"Dual roles for hepatic lectin receptors in the clearance of chilled platelets","volume":"15","author":"Rumjantseva","year":"2009","journal-title":"Nat Med"},{"issue":"5639","key":"10.1002\/rth2.12369_bb0185","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.1085322","article-title":"Glycosylation restores survival of chilled blood platelets","volume":"301","author":"Hoffmeister","year":"2003","journal-title":"Science"},{"issue":"1","key":"10.1002\/rth2.12369_bb0190","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1055\/s-0037-1613607","article-title":"Unexpected persistence of platelet hyporeactivity beyond the neonatal period: a flow cytometric study in neonates, infants and older children","volume":"90","author":"Hezard","year":"2003","journal-title":"Thromb Haemost"},{"issue":"4","key":"10.1002\/rth2.12369_bb0195","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1056\/NEJMoa1505643","article-title":"Von Willebrand factor multimers during transcatheter aortic\u2010valve replacement","volume":"375","author":"Van Belle","year":"2016","journal-title":"N Engl J Med"},{"issue":"suppl_1","key":"10.1002\/rth2.12369_bb0200","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/eurheartj\/ehy566.5065","article-title":"5065 Platelet desialylation induced by high shear\u2010stress mechanical circulatory support","volume":"39","author":"Spillemaeker","year":"2018","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1002\/rth2.12369_bb0205","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.115.002800","article-title":"Frequency of poor outcome (death or poor quality of life) after left ventricular assist device for destination therapy: results from the INTERMACS Registry","volume":"9","author":"Arnold","year":"2016","journal-title":"Circ Heart Fail"},{"issue":"1","key":"10.1002\/rth2.12369_bb0210","first-page":"130","article-title":"Major thrombocytopenia after balloon\u2010expandable transcatheter aortic valve replacement: prognostic implications and comparison to surgical aortic valve replacement","volume":"85","author":"Jilaihawi","year":"2015","journal-title":"Catheter Cardiovasc Interv"},{"issue":"13","key":"10.1002\/rth2.12369_bb0215","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1161\/CIRCULATIONAHA.113.002677","article-title":"Postprocedural aortic regurgitation in balloon\u2010expandable and self\u2010expandable transcatheter aortic valve replacement procedures: analysis of predictors and impact on long\u2010term mortality: insights from the FRANCE2 Registry","volume":"129","author":"Van Belle","year":"2014","journal-title":"Circulation"},{"issue":"38","key":"10.1002\/rth2.12369_bb0220","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1093\/eurheartj\/ehu082","article-title":"Acquired thrombocytopenia after transcatheter aortic valve replacement: clinical correlates and association with outcomes","volume":"35","author":"Dvir","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1002\/rth2.12369_bb0225","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ijcard.2016.07.094","article-title":"TAVI induces an elevation of hemostasis\u2010related biomarkers, which is not causative for post\u2010TAVI thrombocytopenia","volume":"221","author":"Sedaghat","year":"2016","journal-title":"Int J Cardiol"},{"issue":"D1","key":"10.1002\/rth2.12369_bb0230","doi-asserted-by":"crossref","first-page":"D874","DOI":"10.1093\/nar\/gky821","article-title":"AWESOME: a database of SNPs that affect protein post\u2010translational modifications","volume":"47","author":"Yang","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1002\/rth2.12369_bb0235","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41467-019-14178-y","article-title":"beta4GALT1 controls beta1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis","volume":"11","author":"Giannini","year":"2020","journal-title":"Nat Commun"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rth2.12369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rth2.12369","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037922020398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037922020398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rth2.12369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:19:35Z","timestamp":1762863575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037922020398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S2475037922020398"],"URL":"https:\/\/doi.org\/10.1002\/rth2.12369","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Measuring beta\u2010galactose exposure on platelets: Standardization and healthy reference values","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1002\/rth2.12369","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 The Authors. Research and Practice in Thrombosis and Haemostasis published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis","name":"copyright","label":"Copyright"}]}}