{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:56:11Z","timestamp":1788245771139,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":339,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1002\/rth2.12646","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T03:26:05Z","timestamp":1641957965000},"page":"e12646","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Reliable measurement of plasma kinin peptides: Importance of preanalytical variables"],"prefix":"10.1016","volume":"6","author":[{"given":"Tanja","family":"Gangnus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1782-9937","authenticated-orcid":false,"given":"Bjoern B.","family":"Burckhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1002\/rth2.12646_bb0010","series-title":"Handbook of biologically active peptides","first-page":"1386","article-title":"Bradykinin Peptides","author":"Campbell","year":"2013"},{"key":"10.1002\/rth2.12646_bb0015","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59177","article-title":"A mechanistic model and therapeutic interventions for COVID\u201019 involving a RAS\u2010mediated bradykinin storm","volume":"9","author":"Garvin","year":"2020","journal-title":"Elife"},{"key":"10.1002\/rth2.12646_bb0020","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/1354750X.2013.787544","article-title":"The kinin\u2010kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers","volume":"18","author":"Kashuba","year":"2013","journal-title":"Biomarkers"},{"key":"10.1002\/rth2.12646_bb0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40560-017-0228-x","article-title":"The role of contact system in septic shock: the next target? An overview of the current evidence","volume":"5","author":"Nicola","year":"2017","journal-title":"J Intensive Care"},{"key":"10.1002\/rth2.12646_bb0030","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s12016-016-8540-0","article-title":"Bradykinin: inflammatory product of the coagulation system","volume":"51","author":"Hofman","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1002\/rth2.12646_bb0035","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1373\/clinchem.2007.088344","article-title":"Errors in a stat laboratory: types and frequencies 10 years later","volume":"53","author":"Carraro","year":"2007","journal-title":"Clin Chem"},{"key":"10.1002\/rth2.12646_bb0040","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/clinchem\/48.5.691","article-title":"Errors in laboratory medicine","volume":"48","author":"Bonini","year":"2002","journal-title":"Clin Chem"},{"key":"10.1002\/rth2.12646_bb0045","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1309\/ER9P-64EB-MCFR-47KY","article-title":"Preanalytical variables in the coagulation laboratory","volume":"34","author":"Lawrence","year":"2003","journal-title":"Laboratory Medicine"},{"key":"10.1002\/rth2.12646_bb0050","doi-asserted-by":"crossref","first-page":"16120","DOI":"10.1021\/acsomega.0c01723","article-title":"Influence of blood collection methods and long\u2010term plasma storage on quorum\u2010sensing peptide stability","volume":"5","author":"Debunne","year":"2020","journal-title":"ACS Omega"},{"issue":"4","key":"10.1002\/rth2.12646_bb0055","first-page":"H1340","article-title":"Serum interspecies differences in metabolic pathways of bradykinin and [des\u2010Arg9]BK: influence of enalaprilat","volume":"271","author":"Decarie","year":"1996","journal-title":"American Physiological Society"},{"key":"10.1002\/rth2.12646_bb0060","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jchromb.2013.12.033","article-title":"Bradykinin analysis revived\u2013a validated method for determination of its stable metabolite in whole blood by LC\u2010MS\/MS","volume":"947\u2013948","author":"Seip","year":"2014","journal-title":"J Chromatogr B"},{"key":"10.1002\/rth2.12646_bb0065","doi-asserted-by":"crossref","first-page":"R897","DOI":"10.1152\/ajpregu.2000.278.4.R897","article-title":"Kinins in humans","volume":"278","author":"Duncan","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1002\/rth2.12646_bb0070","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0140-6736(97)09137-X","article-title":"Plasma bradykinin in angio\u2010oedema","volume":"351","author":"Nussberger","year":"1998","journal-title":"The Lancet"},{"key":"10.1002\/rth2.12646_bb0075","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cca.2019.02.023","article-title":"Plasma bradykinin concentrations during septic shock determined by a novel LC\u2010MS\/MS assay","volume":"493","author":"Lindstr\u00f6m","year":"2019","journal-title":"Clin Chim Acta"},{"key":"10.1002\/rth2.12646_bb0080","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.jchromb.2010.01.011","article-title":"Quantitative assay for six potential breast cancer biomarker peptides in human serum by liquid chromatography coupled to tandem mass spectrometry","volume":"878","author":"van den Broek","year":"2010","journal-title":"J Chromatogr B"},{"key":"10.1002\/rth2.12646_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180964","article-title":"Plasma bradykinin and early diabetic nephropathy lesions in type 1 diabetes mellitus","volume":"12","author":"Wheelock","year":"2017","journal-title":"PLoS One"},{"issue":"Suppl 9","key":"10.1002\/rth2.12646_bb0090","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1097\/00005344-199200209-00007","article-title":"Antagonizing and measurement: approaches to understanding of hemodynamic effects of kinins","volume":"20","author":"Pellacani","year":"1992","journal-title":"J Cardiovasc Pharmacol"},{"issue":"5","key":"10.1002\/rth2.12646_bb0095","first-page":"H2263","article-title":"Contribution of angiotensin\u2010converting enzyme to the cardiac metabolism of bradykinin: an interspecies study","volume":"273","author":"Blais","year":"1997","journal-title":"American Physiology Society"},{"key":"10.1002\/rth2.12646_bb0100","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/abio.2001.5073","article-title":"Quantification of BK1\u20105, the stable bradykinin plasma metabolite in humans, by a highly accurate liquid\u2010chromatographic tandem mass spectrometric assay","volume":"292","author":"Murphey","year":"2001","journal-title":"Anal Biochem"},{"key":"10.1002\/rth2.12646_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121134","article-title":"Improving sensitivity for the targeted LC\u2010MS\/MS analysis of the peptide bradykinin using a design of experiments approach","volume":"218","author":"Gangnus","year":"2020","journal-title":"Talanta"},{"key":"10.1002\/rth2.12646_bb0110","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1007\/s00216-021-03231-9","article-title":"Targeted LC\u2010MS\/MS platform for the comprehensive determination of peptides in the kallikrein\u2010kinin system","volume":"413","author":"Gangnus","year":"2021","journal-title":"Anal Bioanal Chem"},{"key":"10.1002\/rth2.12646_bb0115","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/clinchem\/hvab129","article-title":"Stabilization of short\u2010lived peptides of the kallikrein\u2010kinin system in human plasma to facilitate use as promising biomarkers","volume":"67","author":"Gangnus","year":"2021","journal-title":"Clin Chem"},{"key":"10.1002\/rth2.12646_bb0120","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jth.13194","article-title":"The contact activation and kallikrein\/kinin systems: Pathophysiologic and physiologic activities","volume":"14","author":"Schmaier","year":"2016","journal-title":"J Thromb Haemost"},{"key":"10.1002\/rth2.12646_bb0125","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/MOH.0b013e32836125ac","article-title":"The role of dipeptidyl peptidase 4 in hematopoiesis and transplantation","volume":"20","author":"O'Leary","year":"2013","journal-title":"Curr Opin Hematol"},{"key":"10.1002\/rth2.12646_bb0130","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/cei.12612","article-title":"Human monocyte subsets exhibit divergent angiotensin I\u2010converting activity","volume":"181","author":"Rutkowska\u2010Zapa\u0142a","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"10.1002\/rth2.12646_bb0135","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0009-8981(91)90061-G","article-title":"Aminopeptidase P and dipeptidyl peptidase IV activity in human leukocytes and in stimulated lymphocytes","volume":"196","author":"Hendriks","year":"1991","journal-title":"Clin Chim Acta"},{"key":"10.1002\/rth2.12646_bb0140","unstructured":"U.S. Food and Drug Administration. Bioanalytical Method Validation: Guidance for Industry. https:\/\/www.fda.gov\/files\/drugs\/published\/Bioanalytical\u2010Method\u2010Validation\u2010Guidance\u2010for\u2010Industry.pdf, 2018."},{"key":"10.1002\/rth2.12646_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2019.113090","article-title":"A quality control system for ligand\u2010binding assay of plasma renin activity: Proof\u2010of\u2010concept within a pharmacodynamic study","volume":"181","author":"Suessenbach","year":"2020","journal-title":"J Pharm Biomed Anal"},{"key":"10.1002\/rth2.12646_bb0150","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fmed.2017.00206","article-title":"The search for biomarkers in hereditary angioedema","volume":"4","author":"Kaplan","year":"2017","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"10.1002\/rth2.12646_bb0155","first-page":"87","article-title":"Effect of hexadimethrine bromide on plasma kinin formation, hydrolysis of p\u2010Tosyl\u2010L\u2010argnine methyl ester and fibrinolysis","volume":"22","author":"Eisen","year":"1964","journal-title":"Br J Pharmacol"},{"key":"10.1002\/rth2.12646_bb0160","first-page":"164","article-title":"Inhibitory effect of a new synthetic protease inhibitor (FUT\u2010175) on the coagulation system","volume":"15","author":"Hitomi","year":"1985","journal-title":"Haemostasis"},{"key":"10.1002\/rth2.12646_bb0165","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1161\/01.HYP.21.2.155","article-title":"Bradykinin peptides in kidney, blood, and other tissues of the rat","volume":"21","author":"Campbell","year":"1993","journal-title":"Hypertension"},{"issue":"Pt 5","key":"10.1002\/rth2.12646_bb0170","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/000456328402100506","article-title":"A kinetic fluorimetric assay for the measurement of angiotensin\u2010converting enzyme in human serum","volume":"21","author":"Maguire","year":"1984","journal-title":"Ann Clin Biochem"},{"key":"10.1002\/rth2.12646_bb0175","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1172\/JCI110015","article-title":"Prolylcarboxypeptidase (angiotensinase C) in human lung and cultured cells","volume":"67","author":"Kumamoto","year":"1981","journal-title":"J Clin Invest"},{"key":"10.1002\/rth2.12646_bb0180","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1160\/TH08-10-0670","article-title":"Monitoring thrombin generation: is addition of corn trypsin inhibitor needed?","volume":"101","author":"Spronk","year":"2009","journal-title":"Thromb Haemost"},{"key":"10.1002\/rth2.12646_bb0185","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1111\/jth.12012","article-title":"Preanalytic variables of thrombin generation: towards a standard procedure and validation of the method","volume":"10","author":"Loeffen","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1002\/rth2.12646_bb0190","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1538-7836.2005.01163.x","article-title":"No influence of a butterfly device on routine coagulation assays and D\u2010dimer measurement","volume":"3","author":"Lippi","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1002\/rth2.12646_bb0195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12959-016-0123-z","article-title":"Pre\u2010analytical issues in the haemostasis laboratory: guidance for the clinical laboratories","volume":"14","author":"Magnette","year":"2016","journal-title":"Thrombosis Journal"},{"key":"10.1002\/rth2.12646_bb0200","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1373\/clinchem.2015.250563","article-title":"Recommendations for the generation, quantification, storage, and handling of peptides used for mass spectrometry\u2013based assays","volume":"62","author":"Hoofnagle","year":"2016","journal-title":"Clin Chem"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rth2.12646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rth2.12646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037922011098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037922011098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rth2.12646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:22:34Z","timestamp":1762863754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037922011098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S2475037922011098"],"URL":"https:\/\/doi.org\/10.1002\/rth2.12646","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reliable measurement of plasma kinin peptides: Importance of preanalytical variables","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1002\/rth2.12646","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 The Authors. Research and Practice in Thrombosis and Haemostasis published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis","name":"copyright","label":"Copyright"}],"article-number":"e12646"}}