{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:42:19Z","timestamp":1791567739503,"version":"4.3.4"},"reference-count":24,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":148,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1002\/rth2.12785","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T03:36:46Z","timestamp":1662694606000},"page":"e12785","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Acquired hemophilia following COVID\u201019 vaccination: Case report and review of literature"],"prefix":"10.1016","volume":"6","author":[{"given":"Michiel","family":"Happaerts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-8918","authenticated-orcid":false,"given":"Thomas","family":"Vanassche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1002\/rth2.12785_bb0010","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ajh.24777","article-title":"Acquired hemophilia A: updated review of evidence and treatment guidance","volume":"92","author":"Kruse\u2010Jarres","year":"2017","journal-title":"Am J Hematol"},{"key":"10.1002\/rth2.12785_bb0015","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1538-7836.2012.04654.x","article-title":"Demographic and clinical data in acquired hemophilia A: results from the European Acquired Hemophilia (EACH2) registry","volume":"10","author":"Knoebl","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"10","key":"10.1002\/rth2.12785_bb0020","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00228-010-0852-z","article-title":"Acquired factor VIII haemophilia following influenza vaccination","volume":"66","author":"Moulis","year":"2010","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1002\/rth2.12785_bb0025","doi-asserted-by":"crossref","DOI":"10.1177\/2058738420934618","article-title":"A previously treated severe haemophilia A patient developed high\u2010titre inhibitor after vaccinations","volume":"34","author":"Li","year":"2020","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"6","key":"10.1002\/rth2.12785_bb0030","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/jth.15291","article-title":"A case report of acquired hemophilia following COVID\u201019 vaccine","volume":"19","author":"Radwi","year":"2021","journal-title":"J Thromb Haemost"},{"issue":"13","key":"10.1002\/rth2.12785_bb0035","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1182\/bloodadvances.2021004957","article-title":"Autoimmune\u2010 and complement\u2010mediated hematologic condition recrudescence following SARS\u2010CoV\u20102 vaccination","volume":"5","author":"Portuguese","year":"2021","journal-title":"Blood Adv"},{"issue":"8","key":"10.1002\/rth2.12785_bb0040","doi-asserted-by":"crossref","first-page":"E197","DOI":"10.1002\/ajh.25865","article-title":"The first case of acquired hemophilia A associated with SARS\u2010CoV\u20102 infection","volume":"95","author":"Franchini","year":"2020","journal-title":"Am J Hematol"},{"issue":"7","key":"10.1002\/rth2.12785_bb0045","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-242884","article-title":"Severe acquired haemophilia associated with asymptomatic SARS\u2010CoV\u20102 infection","volume":"14","author":"Wang","year":"2021","journal-title":"BMJ Case Rep"},{"issue":"21","key":"10.1002\/rth2.12785_bb0050","article-title":"An 89\u2010year\u2010old man with COVID\u201019\u2010associated coagulopathy presenting with a prolonged partial thromboplastin time, lupus anticoagulant, and a high titer of factor VIII inhibitor","volume":"30","author":"Ghafouri","year":"2020","journal-title":"Am J Case Rep"},{"issue":"3","key":"10.1002\/rth2.12785_bb0055","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/trf.16254","article-title":"De novo acquired hemophilia as an immune dysregulation phenomenon following SARS\u2010CoV\u20102 infection","volume":"61","author":"Olsen","year":"2020","journal-title":"Transfusion"},{"issue":"2","key":"10.1002\/rth2.12785_bb0060","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1111\/ijlh.13384","article-title":"Validation of the chromogenic Bethesda assay for factor VIII inhibitors in hemophilia A patients receiving Emicizumab","volume":"43","author":"Miller","year":"2021","journal-title":"Int J Lab Hematol"},{"issue":"3","key":"10.1002\/rth2.12785_bb0065","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1182\/blood.2020006315","article-title":"Emicizumab for the treatment of acquired hemophilia A","volume":"137","author":"Knoebl","year":"2021","journal-title":"Blood"},{"issue":"9396","key":"10.1002\/rth2.12785_bb0070","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0140-6736(03)14802-7","article-title":"Vaccination and autoimmune disease: what is the evidence?","volume":"362","author":"Wraith","year":"2003","journal-title":"Lancet"},{"issue":"7","key":"10.1002\/rth2.12785_bb0075","article-title":"A case of acquired hemophilia A following SARS\u2010CoV\u20102 infection","volume":"13","author":"Hafzah","year":"2021","journal-title":"Cureus"},{"key":"10.1002\/rth2.12785_bb0080","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1055\/a-1579-5396","article-title":"Autoimmunity after coronavirus disease 2019 (COVID\u201019) vaccine: a case of acquired hemophilia A","volume":"121","author":"Farley","year":"2021","journal-title":"Thromb Haemost"},{"issue":"9","key":"10.1002\/rth2.12785_bb0085","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1111\/jth.15421","article-title":"The statistical risk of diagnosing coincidental acquired hemophilia A following anti\u2010SARS\u2010CoV\u20102 vaccination","volume":"19","author":"Cittone","year":"2021","journal-title":"J Thromb Haemost"},{"issue":"2","key":"10.1002\/rth2.12785_bb0090","article-title":"Acquired hemophilia A post\u2010COVID\u201019 vaccination: a case report and review","volume":"14","author":"Al Hennawi","year":"2022","journal-title":"Cureus"},{"issue":"1","key":"10.1002\/rth2.12785_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14740\/jmc3827","article-title":"Acquired hemophilia A developed post COVID\u201019 vaccine: an extremely rare complication","volume":"13","author":"Soliman","year":"2022","journal-title":"J Med Cases"},{"key":"10.1002\/rth2.12785_bb0100","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.thromres.2022.01.017","article-title":"Four cases of acquired hemophilia A following immunization with mRNA BNT162b2 SARS\u2010CoV\u20102 vaccine","volume":"211","author":"Leone","year":"2022","journal-title":"Thromb Res"},{"key":"10.1002\/rth2.12785_bb0105","doi-asserted-by":"crossref","DOI":"10.1177\/10781552221075545","article-title":"Acquired hemophilia A following Pfizer\u2010BioNTech SARS CoV\u20102 mRNA vaccine, successfully treated with prednisolone and rituximab","volume":"28","author":"Murali","year":"2022","journal-title":"J Oncol Pharm Pract"},{"issue":"3","key":"10.1002\/rth2.12785_bb0110","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-246922","article-title":"Case of acquired haemophilia A in Southeast Asia following COVID\u201019 vaccine","volume":"15","author":"Ai Vuen","year":"2022","journal-title":"BMJ Case Rep"},{"issue":"1","key":"10.1002\/rth2.12785_bb0115","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1111\/hae.14442","article-title":"A case of acquired haemophilia A in a 70\u2010year\u2010old post COVID\u201019 vaccine","volume":"28","author":"Lemoine","year":"2022","journal-title":"Haemophilia"},{"key":"10.1002\/rth2.12785_bb0120","doi-asserted-by":"crossref","first-page":"A1384","DOI":"10.1016\/j.chest.2021.07.1265","article-title":"\u201cDark skin\u201d\u2010acquired hemophilia A after Pfizer\u2010Biontech COVID\u201019 vaccine","volume":"160","author":"Gutierrez\u2010Nunez","year":"2021","journal-title":"Chest"},{"issue":"1","key":"10.1002\/rth2.12785_bb0125","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12185-020-03002-9","article-title":"Bullous pemphigoid is a common associated disorder with acquired haemophilia A","volume":"113","author":"Abdul\u2010Halim","year":"2021","journal-title":"Int J Hematol"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rth2.12785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rth2.12785","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037922023512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037922023512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rth2.12785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:24:16Z","timestamp":1762863856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037922023512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S2475037922023512"],"URL":"https:\/\/doi.org\/10.1002\/rth2.12785","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acquired hemophilia following COVID\u201019 vaccination: Case report and review of literature","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1002\/rth2.12785","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 The Authors. Research and Practice in Thrombosis and Haemostasis published by ELSEVIER INC. on behalf of International Society on Thrombosis and Haemostasis (ISTH)","name":"copyright","label":"Copyright"}],"article-number":"e12785"}}