{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T04:32:25Z","timestamp":1698553945414},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T00:00:00Z","timestamp":1339372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scanning"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Papulonodular mucinosis (<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>) is a cutaneous clue to the presence and activity of silent lupus erythematosus (<jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>), but the exact pathogenesis is still under secret. Moreover, the currently available treatments for <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> are not satisfactory. To demonstrate the possibility of multiphoton microscopy (<jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content>) to trace the pathological state of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> and evaluate the treatment efficacy, epidermal and dermal alteration in skin lesion with <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> before and after treatment was examined using <jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content>. Microstructure of epidermis as well as content and distribution of collagen and elastin in dermis were quantified to characterize the pathological states of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>. The results showed significant morphological difference between skin lesion before and after treatment, indicating the possibility of <jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content> to assess the therapeutic efficacy. With the advancement on <jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content> miniaturization and enhancement of contrast and depth of imaging, the <jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content> technique can be applied in <jats:italic>in vivo<\/jats:italic> tracking <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> formation and progression, and leading the better understanding the <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> pathogenesis and mechanism of response to any treatment, helping to establish novel effective therapies for <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>. 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