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These limitations became obvious when we attempted to identify the offending material in the inflamed eye of a patient who complained of foreign body sensation after contact with a pet tarantula As a model of this clinical situation, we used a newly developed tandem scanning confocal microscope to observe and to photograph tarantula hairs as they penetrated the corneal stroma and endothelium and entered the anterior chamber in rabbit eyes. We found that, experimentally, the hairs penetrated the ocular tissues apparently without inciting inflammation or causing fibrosis. The instrument we used\u2010 a prototype with a Nipkow disk from Noran, Inc. (Middleton, Wis.) and a 25\/0.8 na glycerin immersion lens (Plan\u2010Neofluor, Zeiss)\u2013provides magnifications of 100\u2013500X, real\u2010time viewing in vivo, optical sectioning, contrast control, high resolution, processing through image analysis systems, and video and hard copy output. We believe that confocal microscopy offers a new approach to the identification and localization of foreign bodies in the anterior segment, as well as to the visualization and diagnosis of ocular diseases, including bacterial, fungal, and other parasitic invasions, in the human eye.<\/jats:p>","DOI":"10.1002\/sca.4950160511","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T09:49:44Z","timestamp":1278582584000},"page":"312-315","source":"Crossref","is-referenced-by-count":16,"title":["Confocal microscopy of corneal penetration by tarantula hairs"],"prefix":"10.1002","volume":"16","author":[{"given":"S. C.","family":"Kaufman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Chew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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