{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:10:31Z","timestamp":1790745031460,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":1790,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>One-way endobronchial valves (EBV) insertion to reduce pulmonary air trapping has been used as therapy for chronic obstructive pulmonary disease (COPD) patients. However, local inflammation may result and can contribute to worsening of clinical status in these patients. We hypothesized that combined EBV insertion and intrabronchial administration of mesenchymal stromal cells (MSCs) would decrease the inflammatory process, thus mitigating EBV complications in severe COPD patients. This initial study sought to investigate the safety of this approach. For this purpose, a phase I, prospective, patient-blinded, randomized, placebo-controlled design was used. Heterogeneous advanced emphysema (Global Initiative for Chronic Lung Disease [GOLD] III or IV) patients randomly received either allogeneic bone marrow-derived MSCs (108 cells, EBV+MSC) or 0.9% saline solution (EBV) (n\u2009=\u20095 per group), bronchoscopically, just before insertion of one-way EBVs. Patients were evaluated 1, 7, 30, and 90 days after therapy. All patients completed the study protocol and 90-day follow-up. MSC delivery did not result in acute administration-related toxicity, serious adverse events, or death. No significant between-group differences were observed in overall number of adverse events, frequency of COPD exacerbations, or worsening of disease. Additionally, there were no significant differences in blood tests, lung function, or radiological outcomes. However, quality-of-life indicators were higher in EBV\u2009+\u2009MSC compared with EBV. EBV\u2009+\u2009MSC patients presented decreased levels of circulating C-reactive protein at 30 and 90 days, as well as BODE (Body mass index, airway Obstruction, Dyspnea, and Exercise index) and MMRC (Modified Medical Research Council) scores. Thus, combined use of EBV and MSCs appears to be safe in patients with severe COPD, providing a basis for subsequent investigations using MSCs as concomitant therapy.<\/jats:p>","DOI":"10.1002\/sctm.16-0315","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T16:12:50Z","timestamp":1489162370000},"page":"962-969","source":"Crossref","is-referenced-by-count":70,"title":["Combined Bone Marrow-Derived Mesenchymal Stromal Cell Therapy and One-Way Endobronchial Valve Placement in Patients with Pulmonary Emphysema: A Phase I Clinical Trial"],"prefix":"10.1093","volume":"6","author":[{"given":"Hugo Goulart","family":"de Oliveira","sequence":"first","affiliation":[{"name":"a Hospital Moinhos de Vento (HMV), Porto Alegre, Rio Grande do Sul, Brazil"},{"name":"b Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Ferreira","family":"Cruz","sequence":"additional","affiliation":[{"name":"c Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro-RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Alves","family":"Antunes","sequence":"additional","affiliation":[{"name":"c Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro-RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarilio Vieira","family":"Macedo Neto","sequence":"additional","affiliation":[{"name":"a Hospital Moinhos de Vento (HMV), Porto Alegre, Rio Grande do Sul, Brazil"},{"name":"b Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Augusto","family":"Oliveira","sequence":"additional","affiliation":[{"name":"b Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Munhoz","family":"Svartman","sequence":"additional","affiliation":[{"name":"a Hospital Moinhos de Vento (HMV), Porto Alegre, Rio Grande do Sul, Brazil"},{"name":"b Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Borgonovo","sequence":"additional","affiliation":[{"name":"d Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Lucia Kuniyoshi","family":"Rebelatto","sequence":"additional","affiliation":[{"name":"d Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Weiss","sequence":"additional","affiliation":[{"name":"e Vermont Lung Center, College of Medicine, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto Slud","family":"Brofman","sequence":"additional","affiliation":[{"name":"d Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Marcos","family":"Morales","sequence":"additional","affiliation":[{"name":"c Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro-RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Roberto","family":"Lapa e Silva","sequence":"additional","affiliation":[{"name":"f Hospital Universit\u00e1rio Clementino Fraga Filho\/UFRJ, Rio de Janeiro-RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Rieken Macedo","family":"Rocco","sequence":"additional","affiliation":[{"name":"c Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro-RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,9]]},"reference":[{"key":"2022022809524996000_R1","author":"Global Strategy for the Diagnosis, Management and Prevention of COPD","year":"2016"},{"key":"2022022809524996000_R2","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1056\/NEJMoa0900928","article-title":"A randomized study of endobronchial valves for advanced emphysema","volume":"363","author":"Sciurba","year":"2010","journal-title":"N Engl J Med"},{"key":"2022022809524996000_R3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. 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