{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T02:42:24Z","timestamp":1779331344215,"version":"3.51.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":1732,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We sought to evaluate the physiological background and the effects of CD34+ cell transplantation on diastolic parameters in nonischemic dilated cardiomyopathy patients (DCM). We enrolled 38 DCM patients with NYHA class III and LVEF &amp;lt; 40% who underwent transendocardial CD34+ cell transplantation. Peripheral blood CD34+ cells were mobilized by G-CSF, collected via apheresis, and injected transendocardially in the areas of myocardial hibernation. Patients were followed for 1 year. At baseline, estimated filling pressures were significantly elevated (E\/e\u2032\u2009\u2265\u200915) in 18 patients (Group A), and moderately elevated (E\/e\u2009\u2032&amp;lt;\u200915) in 20 patients (Group B). The groups did not differ in age (54\u2009\u00b1\u20099 years vs. 52\u2009\u00b1\u200910 years; p\u2009=\u2009.62), gender (male: 85% vs. 78%; p\u2009=\u2009.57), or LVEF (31\u2009\u00b1\u20097% vs. 34\u2009\u00b1\u20096%; p\u2009=\u2009.37). When compared to Group B patients in Group A had more segments with myocardial scar (4.9\u2009\u00b1\u20092.7 vs. 2.7\u2009\u00b1\u20092.9; p\u2009=\u2009.03), myocardial hibernation (2.2\u2009\u00b1\u20091.6 vs. 0.9\u2009\u00b1\u20091.1; p\u2009=\u2009.02), and longer average local relaxation time on electroanatomical mapping (378\u2009\u00b1\u200941 ms vs. 333\u2009\u00b1\u200934 ms, p\u2009=\u2009.01). During follow-up there was an improvement in diastolic parameters in Group A (E\/e\u2032: from 24.3\u2009\u00b1\u200912.1 to 16.3\u2009\u00b1\u20098.0; p\u2009=\u2009.005), but not in Group B (E\/e\u2032: from 10.2\u2009\u00b1\u20093.7 to 13.2\u2009\u00b1\u20099.1; p\u2009=\u2009.19). Accordingly, in Group A, we found an increase in 6-minute walk distance (from 463\u2009\u00b1\u200983 m to 546\u2009\u00b1\u200991 m; p\u2009=\u2009.03), and a decrease in NT-proBNP (from 2140\u2009\u00b1\u20091743 pg\/ml to 863\u2009\u00b1\u2009836 pg\/ml; p\u2009=\u2009.02). In nonischemic DCM, diastolic dysfunction appears to correlate with areas of myocardial scar and hibernation. Transendocardial CD34+ cell transplantation may improve diastolic parameters in this patient cohort.<\/jats:p>","DOI":"10.1002\/sctm.16-0331","type":"journal-article","created":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T06:25:23Z","timestamp":1489213523000},"page":"1515-1521","source":"Crossref","is-referenced-by-count":24,"title":["Effects of Transendocardial CD34+ Cell Transplantation on Diastolic Parameters in Patients with Nonischemic Dilated Cardiomyopathy"],"prefix":"10.1093","volume":"6","author":[{"given":"Mojca","family":"Bervar","sequence":"first","affiliation":[{"name":"a Department of Cardiology, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirta","family":"Kozelj","sequence":"additional","affiliation":[{"name":"a Department of Cardiology, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Poglajen","sequence":"additional","affiliation":[{"name":"b Advanced Heart Failure and Transplantation Center, UMC Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matjaz","family":"Sever","sequence":"additional","affiliation":[{"name":"c Department of Hematology, UMC Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Zemljic","sequence":"additional","affiliation":[{"name":"b Advanced Heart Failure and Transplantation Center, UMC Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Frljak","sequence":"additional","affiliation":[{"name":"b Advanced Heart Failure and Transplantation Center, UMC Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Cukjati","sequence":"additional","affiliation":[{"name":"d National Blood Transfusion Institute, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Cernelc","sequence":"additional","affiliation":[{"name":"c Department of Hematology, UMC Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Haddad","sequence":"additional","affiliation":[{"name":"e Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojan","family":"Vrtovec","sequence":"additional","affiliation":[{"name":"b Advanced Heart Failure and Transplantation Center, UMC Ljubljana, Slovenia"},{"name":"e Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,3,11]]},"reference":[{"key":"2022022809523556300_R1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.echo.2003.11.002","article-title":"Prevalence, clinical characteristics, quality of life, and prognosis of patients with congestive heart failure and isolated left ventricular diastolic 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