{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:08:54Z","timestamp":1761808134724},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":1604,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Disappointing results of skeletal muscle precursor cell (skMPC) therapy for women with intrinsic urinary sphincter deficiency (ISD) associated urinary incontinence has increased interest in alternative sphincter regenerative approaches. This study was to measure the safety and efficacy of the cell homing chemokine CXCL12 versus skMPCs in a rat model of ISD. Thirty-six adult female Sprague Dawley rats were divided into 6 treatment (Tx) conditions: (a) no ISD\/noTx [Control]; (b) ISD\/noTx; (c) ISD\u2009+\u2009skMPCs; (d) ISD\u2009+\u20093.5 mg CXCL12; (e) ISD\u2009+\u20097mg CXCL12; and (f) ISD\u2009+\u200914 mg CXCL12. Tx's were injected directly into the sphincter complex 30 days post ISD and rats euthanized 30 days post Tx. Blood samples for measurements of kidney and liver function, white and red blood cell counts, were taken at baseline and at euthanasia. Leak point pressures (LPP) were measured prior to, and sphincter collagen\/muscle content measured after, euthanasia. There were no effects of treatments on white or red\/white blood cell counts, kidney\/liver function tests or histopathology of the urinary sphincter complex or surrounding tissues. ISD lowered LPP 35% and sphincter muscle content by 17% versus control rats. CXCL12, but not skMPC injections, restored both LPP to control values in a dose-dependent fashion. Both skMPCs and CXCL12 restored sphincter muscle content to control values. This chemokine approach may represent a novel therapeutic option for ISD and appears, at least short-term, to produce little clinical or tissue pathology.<\/jats:p>","DOI":"10.1002\/sctm.16-0497","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T09:09:22Z","timestamp":1500282562000},"page":"1740-1746","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and Initial Safety Profile of CXCL12 Treatment in a Rodent Model of Urinary Sphincter Deficiency"],"prefix":"10.1093","volume":"6","author":[{"given":"J.","family":"Koudy Williams","sequence":"first","affiliation":[{"name":"a Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Dean","sequence":"additional","affiliation":[{"name":"a Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Lankford","sequence":"additional","affiliation":[{"name":"a Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Erik","family":"Andersson","sequence":"additional","affiliation":[{"name":"a Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina"},{"name":"b Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,7,17]]},"reference":[{"key":"2022022810034250100_R1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1001\/jama.291.8.986","article-title":"Management of urinary incontinence in women: Scientific review","volume":"291","author":"Holroyd-Leduc","year":"2004","journal-title":"JAMA"},{"key":"2022022810034250100_R2","volume-title":"The definition, prevalence, and risk factors for stress urinary incontinence","author":"Luber","year":"2004"},{"key":"2022022810034250100_R3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.addr.2014.11.006","article-title":"Slings for urinary incontinence and the application of cell-based therapy","volume":"82\u201383","author":"Hakim","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"2022022810034250100_R4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jmig.2007.11.004","article-title":"A comprehensive review of suburethral sling procedure complications","volume":"15","author":"Stanford","year":"2008","journal-title":"J Minim Invasive Gynecol"},{"key":"2022022810034250100_R5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-642-16499-6_3","article-title":"Animal models of stress urinary incontinence","volume":"202","author":"Jiang","year":"2011","journal-title":"Handb Exp Pharmacol"},{"issue":"6","key":"2022022810034250100_R6","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1089\/scd.2011.0621","article-title":"Stem cell therapy for stress urinary incontinence: A critical review. 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