{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:03:14Z","timestamp":1790888594462,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":1636,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mesenchymal stem cells (MSCs) have potent immunomodulatory functions and are a promising therapy for immune-mediated inflammatory disorders. We previously demonstrated the efficacy of fresh, autologous, adipose-derived MSCs (ASCs) to treat feline chronic gingivostomatitis (FCGS), a chronic oral mucosal inflammatory disease similar to human oral lichen planus. Here, we investigate the use of fresh allogeneic ASCs for treatment of FCGS in seven cats. Radiolabeled ASCs were also tracked systemically. Each cat received two intravenous injections of 20 million ASCs, 1 month apart. Oral inflammation, blood lymphocyte subsets, anti-fetal bovine serum antibody levels, ASC crossmatching and serum proteins and cytokine concentrations were determined. Four of the 7 cats (57%) responded to treatment [complete clinical remission (n\u2009=\u20092) or substantial clinical improvement (n\u2009=\u20092)]. Three cats were nonresponders. Prior to therapy, most cats had increased circulating CD8+ T cells, decreased CD8lo cells, and a decreased CD4\/CD8 ratio, however clinical resolution was not associated with normalization of these parameters. Nonresponders showed more severe systemic inflammation (neutrophilia, hyperglobulinemia and increased interferon gamma and tumor necrosis factor alpha concentration) prior to ASC therapy. Clinical remission took up to 20 months and no clinical relapse has occurred. A higher fraction of radiolabeled ASCs were identified in the oral cavity of FCGS affected cats than the control cat. The administration of fresh, allogenic ASCs appeared to have lower clinical efficacy with a delayed response as compared to the fresh, autologous ASCs. In addition, the mechanism(s) of action for autologous and allogenic ASCs may differ in this model of oral inflammation.<\/jats:p>","DOI":"10.1002\/sctm.17-0035","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T07:38:23Z","timestamp":1497512303000},"page":"1710-1722","source":"Crossref","is-referenced-by-count":95,"title":["Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis"],"prefix":"10.1093","volume":"6","author":[{"given":"Boaz","family":"Arzi","sequence":"first","affiliation":[{"name":"a Department of Surgical and Radiological Sciences, University of California, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin C.","family":"Clark","sequence":"additional","affiliation":[{"name":"b Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayswarya","family":"Sundaram","sequence":"additional","affiliation":[{"name":"b Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Spriet","sequence":"additional","affiliation":[{"name":"a Department of Surgical and Radiological Sciences, University of California, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.M.","family":"Verstraete","sequence":"additional","affiliation":[{"name":"a Department of Surgical and Radiological Sciences, University of California, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi J","family":"Walker","sequence":"additional","affiliation":[{"name":"b Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan R.","family":"Loscar","sequence":"additional","affiliation":[{"name":"c William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Fazel","sequence":"additional","affiliation":[{"name":"d Department of Dermatology, School of Medicine, University of California, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"d Department of Dermatology, School of Medicine, University of California, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Vapniarsky","sequence":"additional","affiliation":[{"name":"e Department of Biomedical Engineering, University of California, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dori L.","family":"Borjesson","sequence":"additional","affiliation":[{"name":"b Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"2022022809390333600_R1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5966\/sctm.2015-0127","article-title":"Therapeutic efficacy of fresh, autologous mesenchymal stem cells for severe refractory gingivostomatitis in cats","volume":"5","author":"Arzi","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"2022022809390333600_R2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.bbmt.2011.09.003","article-title":"Mesenchymal stromal cells: A new tool against graft-versus-host disease?","volume":"18","author":"Baron","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"2022022809390333600_R3","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.5966\/sctm.2016-0030","article-title":"Clinical-grade human multipotent adult progenitor cells block CD8+ cytotoxic T lymphocytes","volume":"5","author":"Plessers","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"2022022809390333600_R4","doi-asserted-by":"crossref","first-page":"860950","DOI":"10.1155\/2015\/860950","article-title":"Mesenchymal stromal cells and viral infection","volume":"2015","author":"Thanunchai","year":"2015","journal-title":"Stem Cells Int"},{"key":"2022022809390333600_R5","first-page":"370","article-title":"Oral lichen planus: A narrative review","volume":"6","author":"di","year":"2014","journal-title":"Front Biosci (Elite. ED.)"},{"key":"2022022809390333600_R6","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/00016350903136605","article-title":"Oral lichen planus and chronic junctional stomatitis: Differences in lymphocyte subpopulations","volume":"67","author":"Omar","year":"2009","journal-title":"Acta Odontol Scand"},{"key":"2022022809390333600_R7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4103\/0973-029X.84474","article-title":"Oral lichen planus: An update on pathogenesis and treatment","volume":"15","author":"Lavanya","year":"2011","journal-title":"J Oral Maxillofac Pathol"},{"key":"2022022809390333600_R8","doi-asserted-by":"crossref","first-page":"308ps21","DOI":"10.1126\/scitranslmed.aaa9116","article-title":"Companion animals: Translational scientist's new best friends","volume":"7","author":"Kol","year":"2015","journal-title":"Sci Transl Med"},{"key":"2022022809390333600_R9","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/stem.2377","article-title":"Concise review: Stem cell trials using companion animal disease models","volume":"34","author":"Hoffman","year":"2016","journal-title":"Stem Cells"},{"key":"2022022809390333600_R10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/089875640902600301","article-title":"Periodontal health status in a colony of 109 cats","volume":"26","author":"Girard","year":"2009","journal-title":"J Vet Dent"},{"key":"2022022809390333600_R11","doi-asserted-by":"crossref","first-page":"654","DOI":"10.2460\/javma.246.6.654","article-title":"Effect of tooth extraction on stomatitis in cats: 95 cases (2000\u20132013)","volume":"246","author":"Jennings","year":"2015","journal-title":"J Am Vet Med Assoc"},{"key":"2022022809390333600_R12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.archoralbio.2009.11.004","article-title":"Presence and quantification of mast cells in the gingiva of cats with tooth resorption, periodontitis and chronic stomatitis","volume":"55","author":"Arzi","year":"2010","journal-title":"Arch Oral Biol"},{"key":"2022022809390333600_R13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jcpa.2010.09.173","article-title":"Immunohistochemical characterization of oral mucosal lesions in cats with chronic gingivostomatitis","volume":"144","author":"Harley","year":"2011","journal-title":"J Comp Pathol"},{"key":"2022022809390333600_R14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jfms.2007.03.003","article-title":"Prevalence of feline chronic gingivo-stomatitis in first opinion veterinary practice","volume":"9","author":"Healey","year":"2007","journal-title":"J Feline Med Surg"},{"key":"2022022809390333600_R15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fvets.2016.00054","article-title":"Therapeutic management of feline chronic gingivostomatitis: A systematic review of the literature","volume":"3","author":"Winer","year":"2016","journal-title":"Front Vet Sci"},{"key":"2022022809390333600_R16","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0195-5616(92)50130-9","article-title":"Inflammatory oral cavity diseases of the cat","volume":"22","author":"Pedersen","year":"1992","journal-title":"Vet Clin North Am Small Anim Prac"},{"key":"2022022809390333600_R17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jfms.2009.10.007","article-title":"Association of Bartonella species, feline calicivirus, and feline herpesvirus 1 infection with gingivostomatitis in cats","volume":"12","author":"Dowers","year":"2010","journal-title":"J Feline Med Surg"},{"key":"2022022809390333600_R18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jfms.2011.05.012","article-title":"Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: A randomised, multi-centre, controlled, double-blind study in 39 cats","volume":"13","author":"Hennet","year":"2011","journal-title":"J Feline Med Surg"},{"key":"2022022809390333600_R19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1034\/j.1399-302X.2003.00033.x","article-title":"Concurrent oral shedding of feline calicivirus and feline herpesvirus 1 in cats with chronic gingivostomatitis","volume":"18","author":"Lommer","year":"2003","journal-title":"Oral Microbiol Immunol"},{"key":"2022022809390333600_R20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cll.2010.12.001","article-title":"The regenerative medicine laboratory: Facilitating stem cell therapy for equine disease","volume":"31","author":"Borjesson","year":"2011","journal-title":"Clin Lab Med"},{"key":"2022022809390333600_R21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. 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