{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T13:37:44Z","timestamp":1786196264002,"version":"build-2736575974"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":1624,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative cells (ADRC) for treating lymphedema with 6 months follow-up. Ten BCRL patients were included. ADRC was injected directly into the axillary region, which was combined with a scar-releasing fat graft procedure. Primary endpoints were change in arm volume. Secondary endpoints were change in patient reported outcome and safety. The study is registered with ClinicalTrials.gov (NCT02592213). During follow-up, a small volume reduction was noted but was not significant. Five patients reduced their use of conservative management. Patient-reported outcomes improved significantly over time. ADRCs were well tolerated and only minor transient adverse events related to liposuction were noted. In this pilot study, a single injection of ADRC improved lymphedema based on patient-reported outcome measures, and there were no serious adverse events in the 6 months follow-up period. In addition, half of the patients reduced their use of conservative management. ADRC therapy is a promising interventional therapy for alleviating lymphedema, but results need to be confirmed in randomized clinical trials.<\/jats:p>","DOI":"10.1002\/sctm.17-0037","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T05:20:38Z","timestamp":1498540838000},"page":"1666-1672","source":"Crossref","is-referenced-by-count":44,"title":["Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study"],"prefix":"10.1093","volume":"6","author":[{"given":"Navid Mohamadpour","family":"Toyserkani","sequence":"first","affiliation":[{"name":"a Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark"},{"name":"b The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark"},{"name":"c Clinical Institute, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Harken","family":"Jensen","sequence":"additional","affiliation":[{"name":"b The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark"},{"name":"d Laboratory of Molecular and Cellular Cardiology, Odense University Hospital, Odense, Denmark"},{"name":"e Clinical Biochemistry and Pharmacology, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte Caroline","family":"Andersen","sequence":"additional","affiliation":[{"name":"b The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark"},{"name":"c Clinical Institute, University of Southern Denmark, Odense, Denmark"},{"name":"d Laboratory of Molecular and Cellular Cardiology, Odense University Hospital, Odense, Denmark"},{"name":"e Clinical Biochemistry and Pharmacology, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Paludan","family":"Sheikh","sequence":"additional","affiliation":[{"name":"b The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark"},{"name":"d Laboratory of Molecular and Cellular Cardiology, Odense University Hospital, Odense, Denmark"},{"name":"e Clinical Biochemistry and Pharmacology, University of Southern Denmark, Odense, Denmark"},{"name":"f Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Ahm","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"a Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark"},{"name":"b The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark"},{"name":"c Clinical Institute, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"2022022809341272200_R1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S1470-2045(13)70076-7","article-title":"Incidence of unilateral arm lymphoedema after breast cancer: A systematic review and meta-analysis","volume":"14","author":"DiSipio","year":"2013","journal-title":"Lancet Oncol"},{"key":"2022022809341272200_R2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.critrevonc.2014.06.004","article-title":"Lymphedema following breast cancer treatment and impact on quality of life: A review","volume":"92","author":"Taghian","year":"2014","journal-title":"Crit Rev Oncol Hematol"},{"key":"2022022809341272200_R3","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1136\/bmj.318.7198.1591","article-title":"Risk factors for erysipelas of the leg (cellulitis): Case-control study","volume":"318","author":"Dupuy","year":"1999","journal-title":"BMJ"},{"key":"2022022809341272200_R4","first-page":"1","article-title":"Consensus Document of the International Society of Lymphology","volume":"46","author":"International Society of Lymphology. 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