{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:41:44Z","timestamp":1792633304683,"version":"4.5.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":1512,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canadian Stem Cell Foundation"},{"DOI":"10.13039\/501100019967","name":"Ontario Lung Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100019967","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Children's Hospital of Eastern Ontario Research Institute"},{"DOI":"10.13039\/100009519","name":"Ottawa Hospital Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009519","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extreme prematurity is the leading cause of death among children under 5 years of age. Currently, there is no treatment for bronchopulmonary dysplasia (BPD), the most common complication of extreme prematurity. Experimental studies in animal models of BPD suggest that mesenchymal stromal cells (MSCs) are lung protective. To date, no systematic review and meta-analysis has evaluated the preclinical evidence of this promising therapy. Our protocol was registered with Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies prior to searching MEDLINE (1946 to June 1, 2015), Embase (1947 to 2015 Week 22), Pubmed, Web of Science, and conference proceedings (1990 to present) for controlled comparative studies of neonatal animal models that received MSCs or cell free MSC-derived conditioned media (MSC-CM). Lung alveolarization was the primary outcome. We used random effects models for data analysis and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines. We screened 990 citations; 25 met inclusion criteria. All used hyperoxia-exposed neonatal rodents to model BPD. MSCs significantly improved alveolarization (Standardized mean difference of \u22121.330, 95% confidence interval [CI \u22121.724, \u22120.94, I2 69%]), irrespective of timing of treatment, source, dose, or route of administration. MSCs also significantly ameliorated pulmonary hypertension, lung inflammation, fibrosis, angiogenesis, and apoptosis. Similarly, MSC-CM significantly improved alveolarization, angiogenesis, and pulmonary artery remodeling. MSCs, tested exclusively in hyperoxic rodent models of BPD, show significant therapeutic benefit. Unclear risk of bias and incomplete reporting in the primary studies highlights nonadherence to reporting standards. Overall, safety and efficacy in other species\/large animal models may provide useful information for guiding the design of clinical trials.<\/jats:p>","DOI":"10.1002\/sctm.17-0126","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T04:56:54Z","timestamp":1508302614000},"page":"2079-2093","source":"Crossref","is-referenced-by-count":131,"title":["Mesenchymal Stromal Cell Therapy in Bronchopulmonary Dysplasia: Systematic Review and Meta-Analysis of Preclinical Studies"],"prefix":"10.1093","volume":"6","author":[{"given":"Sajit","family":"Augustine","sequence":"first","affiliation":[{"name":"a Division of Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc T.","family":"Avey","sequence":"additional","affiliation":[{"name":"b Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"},{"name":"c Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Harrison","sequence":"additional","affiliation":[{"name":"c Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Locke","sequence":"additional","affiliation":[{"name":"c Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Ghannad","sequence":"additional","affiliation":[{"name":"b Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Moher","sequence":"additional","affiliation":[{"name":"b Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"},{"name":"d School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Th\u00e9baud","sequence":"additional","affiliation":[{"name":"a Division of Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada"},{"name":"c Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"e Ottawa Hospital Research Institute, Sinclair Centre for Regenerative Medicine, Ottawa, Ontario, Canada"},{"name":"f Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"2022022809404147000_R1","doi-asserted-by":"crossref","first-page":"263ed21","DOI":"10.1126\/scitranslmed.aaa2563","article-title":"Preterm birth: Now the leading cause of child death 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