{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:11:09Z","timestamp":1783195869155,"version":"3.54.6"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":1408,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Slovenian Research Agency","doi-asserted-by":"publisher","award":["#J3\u20137312"],"award-info":[{"award-number":["#J3\u20137312"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We investigated the effects of CD34+ cell therapy on right ventricular (RV) function in patients with nonischemic dilated cardiomyopathy (DCM). We enrolled 60 patients with DCM who were randomized to CD34+ cell therapy (Stem Cells (SC) Group n\u2009=\u200930), or no cell therapy (Controls, n\u2009=\u200930). The SC Group received granulocyte-colony stimulating factor, and CD34+ cells were collected by apheresis and injected transendocardially. Patients were followed for 6 months. At baseline, the groups did not differ in age, gender, left ventricular ejection fraction, N-terminal probrain natriuretic peptide, or parameters of RV function. At 6 months, we found a significant improvement in RV function in the SC Group (tricuspid annular plane systolic excursion [TAPSE]: +0.44\u2009\u00b1\u20090.64 cm, p\u2009=\u2009.001; peak systolic tissue Doppler velocity of tricuspid annulus [St]: +1.5\u2009\u00b1\u20092.1 cm\/s; p\u2009=\u2009.001; percent of fractional area change [FAC]: +8.6%\u2009\u00b1\u20095%, p\u2009=\u2009.01), but not in Controls (TAPSE: \u22120.07\u2009\u00b1\u20090.32 cm, p\u2009=\u2009.40; St: \u22120.1\u2009\u00b1\u20091.2 cm\/s; p\u2009=\u2009.44; FAC: \u22121.2%\u2009\u00b1\u20093.2%, p\u2009=\u2009.50). On repeat electroanatomical mapping, we found an improvement in interventricular septum viability in 19 of 30 patients from the SC Group; this correlated with the improvements in RV function (13\/19 in the improved septum group versus 3\/11 in the remaining cohort, p\u2009=\u2009.029). These results suggest that patients with DCM, changes in RV function correlate with changes of viability of interventricular septum. CD34+ cell therapy appears to be associated with improved right ventricular function in this patient cohort. (Clinical Trial Registration Information: www.clinicaltrials.gov; NCT02248532).<\/jats:p>","DOI":"10.1002\/sctm.17-0197","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T02:45:15Z","timestamp":1517280315000},"page":"168-172","source":"Crossref","is-referenced-by-count":23,"title":["CD34+ Cell Transplantation Improves Right Ventricular Function in Patients with Nonischemic Dilated Cardiomyopathy"],"prefix":"10.1093","volume":"7","author":[{"given":"Sabina","family":"Frljak","sequence":"first","affiliation":[{"name":"a Advanced Heart Failure and Transplantation Centre, UMC Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Jaklic","sequence":"additional","affiliation":[{"name":"a Advanced Heart Failure and Transplantation Centre, UMC Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Zemljic","sequence":"additional","affiliation":[{"name":"a Advanced Heart Failure and Transplantation Centre, UMC Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andraz","family":"Cerar","sequence":"additional","affiliation":[{"name":"a Advanced Heart Failure and Transplantation Centre, UMC Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Poglajen","sequence":"additional","affiliation":[{"name":"a Advanced Heart Failure and Transplantation Centre, UMC Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan","family":"Vrtovec","sequence":"additional","affiliation":[{"name":"a Advanced Heart Failure and Transplantation Centre, UMC Ljubljana, Slovenia"},{"name":"b Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"2022022808492783100_sct312271-bib-0001","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.healun.2013.08.006","article-title":"The Registry of the International Society for Heart and Lung Transplantation: Thirtieth Official Adult Heart Transplant Report\u20142013; focus theme: Age","volume":"32","author":"Lund","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"2022022808492783100_sct312271-bib-0002","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/HCO.0000000000000164","article-title":"Diagnosing and treating the failing right heart","volume":"30","author":"Ryan","year":"2015","journal-title":"Curr Opin Cardiol"},{"key":"2022022808492783100_sct312271-bib-0003","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1161\/CIRCULATIONAHA.107.653576","article-title":"Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle","volume":"117","author":"Haddad","year":"2008","journal-title":"Circulation"},{"key":"2022022808492783100_sct312271-bib-0004","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1161\/CIRCULATIONAHA.112.000230","article-title":"Comparison of transendocardial and intracoronary CD34+ cell transplantation in patients with nonischemic dilated cardiomyopathy","volume":"128","author":"Vrtovec","year":"2013","journal-title":"Circulation"},{"key":"2022022808492783100_sct312271-bib-0005","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/CIRCRESAHA.112.276519","article-title":"Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up","volume":"112","author":"Vrtovec","year":"2013","journal-title":"Circ Res"},{"key":"2022022808492783100_sct312271-bib-0006","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1093\/eurheartj\/ehv390","article-title":"Randomized trial of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with non-ischaemic dilated cardiomyopathy: The REGENERATE-DCM clinical trial","volume":"36","author":"Hamshere","year":"2015","journal-title":"Eur Heart J"},{"key":"2022022808492783100_sct312271-bib-0007","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jacc.2016.11.009","article-title":"Randomized comparison of allogeneic versus autologous mesenchymal stem cells for nonischemic dilated cardiomyopathy: POSEIDON-DCM trial","volume":"69","author":"Hare","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2022022808492783100_sct312271-bib-0008","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). 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