{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T03:31:46Z","timestamp":1784431906269,"version":"3.55.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":1218,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD091323"],"award-info":[{"award-number":["R01HD091323"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Over the past decade, amniotic fluid-derived stem cells have emerged as a novel experimental approach aimed at improving outcomes in children with congenital anomalies, including spina bifida, heart defects, and diaphragmatic hernia. Interest in these cells for the treatment of prenatally diagnosed diseases has arisen based on numerous studies demonstrating the relative ease of harvesting an abundant quantity of amniocytes from a small aliquot of fluid, the unique properties of amniocytes themselves, and the beneficial effects of amniotic fluid-derived stem cells in experimental animal models. This report gives a brief overview of the rationale and current status of amniotic fluid stem cell-based therapies, focusing on its relevance to birth defects affecting the fetus and neonate. The author proposes a roadmap for further study that would be required prior to clinical application of amniotic fluid stem cell technologies.<\/jats:p>","DOI":"10.1002\/sctm.18-0018","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T14:30:13Z","timestamp":1533652213000},"page":"767-773","source":"Crossref","is-referenced-by-count":27,"title":["Amniotic Fluid Stem Cells for the Treatment of Surgical Disorders in the Fetus and Neonate"],"prefix":"10.1093","volume":"7","author":[{"given":"Shaun M.","family":"Kunisaki","sequence":"first","affiliation":[{"name":"Department of Surgery, Fetal Diagnosis and Treatment Center and Section of Pediatric Surgery University of Michigan, C.S. Mott Children's and Von Voigtlander Women's Hospital, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"issue":"suppl 1","key":"2022022809002971200_sct312346-bib-0001","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1472-6483(10)60111-3","article-title":"Stem cells derived from amniotic fluid: New potentials in regenerative medicine","volume":"18","author":"Cananzi","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"2022022809002971200_sct312346-bib-0002","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1517\/14712598.2011.587800","article-title":"The potential of amniotic fluid stem cells for cellular therapy and tissue engineering","volume":"11","author":"Klemmt","year":"2011","journal-title":"Expert Opin Biol Ther"},{"key":"2022022809002971200_sct312346-bib-0003","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/GCO.0b013e32834457b1","article-title":"Clinical applications of prenatal and postnatal therapy using stem cells retrieved from amniotic fluid","volume":"23","author":"Shaw","year":"2011","journal-title":"Curr Opin Obstet Gynecol"},{"key":"2022022809002971200_sct312346-bib-0004","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jpedsurg.2015.10.016","article-title":"Transplantation of amniotic fluid-derived neural stem cells as a potential novel therapy for Hirschsprung's disease","volume":"51","author":"Zhou","year":"2016","journal-title":"J Pediatr Surg"},{"key":"2022022809002971200_sct312346-bib-0005","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejogrb.2014.04.007","article-title":"Routine isolation and expansion late mid trimester amniotic fluid derived mesenchymal stem cells in a cohort of fetuses with congenital diaphragmatic hernia","volume":"178","author":"DeKoninck","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2022022809002971200_sct312346-bib-0006","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.jpedsurg.2007.01.031","article-title":"Tissue engineering from human mesenchymal amniocytes: A prelude to clinical trials","volume":"42","author":"Kunisaki","year":"2007","journal-title":"J Pediatr Surg"},{"key":"2022022809002971200_sct312346-bib-0007","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/uog.14636","article-title":"Procedure-related risk of miscarriage following amniocentesis and chorionic villus sampling: A systematic review and meta-analysis","volume":"45","author":"Akolekar","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2022022809002971200_sct312346-bib-0008","first-page":"269","article-title":"Fetal tissue sampling\u2014Indications, techniques, complications, and experience with sampling of fetal skin, liver, and muscle","volume":"159","author":"Cadrin","year":"1993","journal-title":"West J Med"},{"key":"2022022809002971200_sct312346-bib-0009","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1089\/scd.2011.0435","article-title":"Human amniotic mesenchymal stem cell-derived induced pluripotent stem cells may generate a universal source of cardiac cells","volume":"21","author":"Ge","year":"2012","journal-title":"Stem Cells Dev"},{"key":"2022022809002971200_sct312346-bib-0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2174\/1574888X113086660067","article-title":"Human amniotic fluid stem cells suppress PBMC proliferation through IDO and IL-10-dependent pathways","volume":"9","author":"Luo","year":"2014","journal-title":"Curr Stem Cell Res Ther"},{"key":"2022022809002971200_sct312346-bib-0011","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S1072-7515(02)01834-3","article-title":"Fetal tissue engineering from amniotic fluid","volume":"196","author":"Kaviani","year":"2003","journal-title":"J Am Coll Surg"},{"key":"2022022809002971200_sct312346-bib-0012","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3727\/096368916X691006","article-title":"Autologous transplantation of amniotic fluid-derived mesenchymal stem cells into sheep fetuses","volume":"25","author":"Shaw","year":"2016","journal-title":"Cell Transplant"},{"key":"2022022809002971200_sct312346-bib-0013","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1089\/1076327041348419","article-title":"Fetal liver as a source of autologous progenitor cells for perinatal tissue engineering","volume":"10","author":"Krupnick","year":"2004","journal-title":"Tissue Eng"},{"key":"2022022809002971200_sct312346-bib-0014","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"2022022809002971200_sct312346-bib-0015","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1182\/blood-2003-04-1291","article-title":"Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation","volume":"102","author":"In't Anker","year":"2003","journal-title":"Blood"},{"key":"2022022809002971200_sct312346-bib-0016","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/humrep\/deg279","article-title":"Oct-4-expressing cells in human amniotic fluid: A new source for stem cell research?","volume":"18","author":"Prusa","year":"2003","journal-title":"Hum Reprod"},{"key":"2022022809002971200_sct312346-bib-0017","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1089\/scd.2006.15.245","article-title":"Fetal cartilage engineering from amniotic mesenchymal progenitor cells","volume":"15","author":"Kunisaki","year":"2006","journal-title":"Stem Cells Dev"},{"key":"2022022809002971200_sct312346-bib-0018","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s13287-017-0582-6","article-title":"Term amniotic fluid: An unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications","volume":"8","author":"Moraghebi","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"2022022809002971200_sct312346-bib-0019","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3109\/14653249.2010.547466","article-title":"Lifespan of human amniotic fluid-derived multipotent mesenchymal stromal cells","volume":"13","author":"Miranda-Sayago","year":"2011","journal-title":"Cytotherapy"},{"key":"2022022809002971200_sct312346-bib-0020","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1089\/scd.2007.0036","article-title":"Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: Comparison to bone marrow mesenchymal stem cells","volume":"16","author":"Roubelakis","year":"2007","journal-title":"Stem Cells Dev"},{"key":"2022022809002971200_sct312346-bib-0021","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12015-010-9116-7","article-title":"Probing stemness and neural commitment in human amniotic fluid cells","volume":"6","author":"Jezierski","year":"2010","journal-title":"Stem Cell Rev"},{"key":"2022022809002971200_sct312346-bib-0022","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1089\/scd.2010.0379","article-title":"Amniotic mesenchymal stem cells enhance normal fetal wound healing","volume":"20","author":"Klein","year":"2011","journal-title":"Stem Cells Dev"},{"key":"2022022809002971200_sct312346-bib-0023","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.exphem.2015.10.009","article-title":"Immunoregulatory effects on T lymphocytes by human mesenchymal stromal cells isolated from bone marrow, amniotic fluid, and placenta","volume":"44","author":"Mareschi","year":"2016","journal-title":"Exp Hematol"},{"key":"2022022809002971200_sct312346-bib-0024","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nbt1274","article-title":"Isolation of amniotic stem cell lines with potential for therapy","volume":"25","author":"De Coppi","year":"2007","journal-title":"Nat Biotechnol"},{"key":"2022022809002971200_sct312346-bib-0025","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.juro.2006.09.103","article-title":"Amniotic fluid and bone marrow derived mesenchymal stem cells can be converted to smooth muscle cells in the cryo-injured rat bladder and prevent compensatory hypertrophy of surviving smooth muscle cells","volume":"177","author":"De Coppi","year":"2007","journal-title":"J Urol"},{"key":"2022022809002971200_sct312346-bib-0026","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/term.308","article-title":"In vitro cardiomyogenic potential of human amniotic fluid stem cells","volume":"5","author":"Guan","year":"2011","journal-title":"J Tissue Eng Regen Med"},{"key":"2022022809002971200_sct312346-bib-0027","doi-asserted-by":"crossref","first-page":"e26535","DOI":"10.1371\/journal.pone.0026535","article-title":"Cloned, CD117 selected human amniotic fluid stem cells are capable of modulating the immune response","volume":"6","author":"Moorefield","year":"2011","journal-title":"PLoS One"},{"key":"2022022809002971200_sct312346-bib-0028","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1089\/scd.2010.0424","article-title":"Amniotic fluid stem cells are cardioprotective following acute myocardial infarction","volume":"20","author":"Bollini","year":"2011","journal-title":"Stem Cells Dev"},{"key":"2022022809002971200_sct312346-bib-0029","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s10616-012-9441-6","article-title":"Human amniotic fluid-derived c-kit(+) and c-kit (\u2212) stem cells: growth characteristics and some differentiation potential capacities comparison","volume":"64","author":"Bai","year":"2012","journal-title":"Cytotechnology"},{"key":"2022022809002971200_sct312346-bib-0030","doi-asserted-by":"crossref","first-page":"9826","DOI":"10.1073\/pnas.0904689106","article-title":"Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases","volume":"106","author":"Ye","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022022809002971200_sct312346-bib-0031","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1093\/hmg\/ddp386","article-title":"Pluripotency can be rapidly and efficiently induced in human amniotic fluid-derived cells","volume":"18","author":"Li","year":"2009","journal-title":"Hum Mol Genet"},{"key":"2022022809002971200_sct312346-bib-0032","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1089\/cell.2009.0077","article-title":"Amniotic fluid cells are more efficiently reprogrammed to pluripotency than adult cells","volume":"12","author":"Galende","year":"2010","journal-title":"Cell Reprogram"},{"key":"2022022809002971200_sct312346-bib-0033","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/hmg\/ddq542","article-title":"Amniocytes can serve a dual function as a source of iPS cells and feeder layers","volume":"20","author":"Anchan","year":"2011","journal-title":"Hum Mol Genet"},{"key":"2022022809002971200_sct312346-bib-0034","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1089\/scd.2014.0110","article-title":"Human transgene-free amniotic-fluid-derived induced pluripotent stem cells for autologous cell therapy","volume":"23","author":"Jiang","year":"2014","journal-title":"Stem Cells Dev"},{"key":"2022022809002971200_sct312346-bib-0035","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1089\/scd.2012.0267","article-title":"Human mid-trimester amniotic fluid stem cells cultured under embryonic stem cell conditions with valproic acid acquire pluripotent characteristics","volume":"22","author":"Moschidou","year":"2013","journal-title":"Stem Cells Dev"},{"key":"2022022809002971200_sct312346-bib-0036","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1182\/blood-2010-12-325324","article-title":"Human mesenchymal stem cells derived from induced pluripotent stem cells down-regulate NK-cell cytolytic machinery","volume":"118","author":"Giuliani","year":"2011","journal-title":"Blood"},{"key":"2022022809002971200_sct312346-bib-0037","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1014379","article-title":"A randomized trial of prenatal versus postnatal repair of myelomeningocele","volume":"364","author":"Adzick","year":"2011","journal-title":"N Engl J Med"},{"key":"2022022809002971200_sct312346-bib-0038","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4161\/org.22238","article-title":"Congenital anomalies: treatment options based on amniotic fluid-derived stem cells","volume":"8","author":"Kunisaki","year":"2012","journal-title":"Organogenesis"},{"key":"2022022809002971200_sct312346-bib-0039","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jpedsurg.2014.10.004","article-title":"Partial or complete coverage of experimental spina bifida by simple intra-amniotic injection of concentrated amniotic mesenchymal stem cells","volume":"50","author":"Dionigi","year":"2015","journal-title":"J Pediatr Surg"},{"key":"2022022809002971200_sct312346-bib-0040","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.stemcr.2017.05.013","article-title":"Fetal therapy model of myelomeningocele with three-dimensional skin using amniotic fluid cell-derived induced pluripotent stem cells","volume":"8","author":"Kajiwara","year":"2017","journal-title":"Stem Cell Rep"},{"key":"2022022809002971200_sct312346-bib-0041","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000350267","article-title":"Intra-amniotic delivery of amniotic-derived neural stem cells in a syngeneic model of spina bifida","volume":"34","author":"Turner","year":"2013","journal-title":"Fetal Diagn Ther"},{"key":"2022022809002971200_sct312346-bib-0042","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nm0495-342","article-title":"In utero surgery rescues neurological function at birth in sheep with spina bifida","volume":"1","author":"Meuli","year":"1995","journal-title":"Nat Med"},{"key":"2022022809002971200_sct312346-bib-0043","doi-asserted-by":"crossref","first-page":"034103","DOI":"10.1088\/1748-6041\/10\/3\/034103","article-title":"Amniotic fluid-derived stem cells demonstrate limited cardiac differentiation following small molecule-based modulation of Wnt signaling pathway","volume":"10","author":"Connell","year":"2015","journal-title":"Biomed Mater"},{"key":"2022022809002971200_sct312346-bib-0044","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.5966\/sctm.2016-0016","article-title":"Human cardiomyocytes prior to birth by integration-free reprogramming of amniotic fluid cells","volume":"5","author":"Jiang","year":"2016","journal-title":"Stem Cells Translational Medicine"},{"key":"2022022809002971200_sct312346-bib-0045","doi-asserted-by":"crossref","first-page":"e0177824","DOI":"10.1371\/journal.pone.0177824","article-title":"Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells","volume":"12","author":"Velasquez-Mao","year":"2017","journal-title":"PLoS One"},{"key":"2022022809002971200_sct312346-bib-0046","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1016\/j.biomaterials.2010.04.069","article-title":"Cardiac repair with injectable cell sheet fragments of human amniotic fluid stem cells in an immune-suppressed rat model","volume":"31","author":"Yeh","year":"2010","journal-title":"Biomaterials"},{"key":"2022022809002971200_sct312346-bib-0047","doi-asserted-by":"crossref","first-page":"I64","DOI":"10.1161\/CIRCULATIONAHA.106.681494","article-title":"Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source","volume":"116","author":"Schmidt","year":"2007","journal-title":"Circulation"},{"key":"2022022809002971200_sct312346-bib-0048","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1016\/j.biomaterials.2011.11.087","article-title":"Prenatally engineered autologous amniotic fluid stem cell-based heart valves in the fetal circulation","volume":"33","author":"Weber","year":"2012","journal-title":"Biomaterials"},{"key":"2022022809002971200_sct312346-bib-0049","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jpedsurg.2004.02.014","article-title":"Diaphragmatic reconstruction with autologous tendon engineered from mesenchymal amniocytes","volume":"39","author":"Fuchs","year":"2004","journal-title":"J Pediatr Surg"},{"key":"2022022809002971200_sct312346-bib-0050","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpedsurg.2005.10.011","article-title":"Diaphragmatic repair through fetal tissue engineering: A comparison between mesenchymal amniocyte- and myoblast-based constructs","volume":"41","author":"Kunisaki","year":"2006","journal-title":"J Pediatr Surg"},{"key":"2022022809002971200_sct312346-bib-0051","doi-asserted-by":"crossref","first-page":"F69","DOI":"10.1136\/fn.82.1.F69","article-title":"Lung growth: Implications for the newborn infant","volume":"82","author":"Kotecha","year":"2000","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2022022809002971200_sct312346-bib-0052","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3727\/096368912X657756","article-title":"Amniotic fluid stem cells rescue both in vitro and in vivo growth, innervation, and motility in nitrofen-exposed hypoplastic rat lungs through paracrine effects","volume":"22","author":"Pederiva","year":"2013","journal-title":"Cell Transplant"},{"key":"2022022809002971200_sct312346-bib-0053","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.jpedsurg.2014.01.013","article-title":"Amniotic fluid derived mesenchymal stromal cells augment fetal lung growth in a nitrofen explant model","volume":"49","author":"Di Bernardo","year":"2014","journal-title":"J Pediatr Surg"},{"key":"2022022809002971200_sct312346-bib-0054","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/pd.4621","article-title":"The use of human amniotic fluid stem cells as an adjunct to promote pulmonary development in a rabbit model for congenital diaphragmatic hernia","volume":"35","author":"DeKoninck","year":"2015","journal-title":"Prenat Diagn"},{"key":"2022022809002971200_sct312346-bib-0055","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jpedsurg.2005.12.008","article-title":"Fetal tracheal reconstruction with cartilaginous grafts engineered from mesenchymal amniocytes","volume":"41","author":"Kunisaki","year":"2006","journal-title":"J Pediatr Surg"},{"key":"2022022809002971200_sct312346-bib-0056","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S0140-6736(12)60737-5","article-title":"Stem-cell-based, tissue engineered tracheal replacement in a child: A 2-year follow-up study","volume":"380","author":"Elliott","year":"2012","journal-title":"Lancet"},{"key":"2022022809002971200_sct312346-bib-0057","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jpedsurg.2015.10.011","article-title":"Transamniotic stem cell therapy (TRASCET) mitigates bowel damage in a model of gastroschisis","volume":"51","author":"Feng","year":"2016","journal-title":"J Pediatr Surg"},{"key":"2022022809002971200_sct312346-bib-0058","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/gutjnl-2012-303735","article-title":"Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism","volume":"63","author":"Zani","year":"2014","journal-title":"Gut"},{"key":"2022022809002971200_sct312346-bib-0059","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jpedsurg.2017.03.028","article-title":"Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells","volume":"52","author":"McCulloh","year":"2017","journal-title":"J Pediatr Surg"},{"key":"2022022809002971200_sct312346-bib-0060","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1089\/scd.2014.0426","article-title":"Amniotic fluid: A source for clinical therapeutics in the newborn?","volume":"24","author":"Ekblad","year":"2015","journal-title":"Stem Cells Dev"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsctm.18-0018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/7\/11\/767\/42625274\/stcltm_7_11_767.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/7\/11\/767\/42625274\/stcltm_7_11_767.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T09:04:20Z","timestamp":1646039060000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/7\/11\/767\/6449267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":60,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,8,7]]},"published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/sctm.18-0018","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,11,1]]},"published":{"date-parts":[[2018,8,7]]}}}