{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:20:37Z","timestamp":1793654437981,"version":"4.5.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":974,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mesenchymal stem cells (MSCs) have been the focus of an emerging treatment for osteoarthritis. However, few studies reported about outcomes of an intra-articular injection of autologous adipose-derived mesenchymal stem cells (AD-MSCs). This study aimed to assess the efficacy and safety of a single intra-articular injection of AD-MSCs for patients with knee osteoarthritis. It was a prospective double-blinded, randomized controlled, phase IIb clinical trial. AD-MSCs were administered for 12 patients (MSC group), and the group was compared with 12 knees with injection of normal saline (control group) up to 6 months. All procedures were performed in the outpatient clinic. Primary outcome measure was the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) score. Secondary outcome measure included various clinical and radiologic examination, and safety after injection. Change of cartilage defect after injection was evaluated using magnetic resonance imaging (MRI). Single injection of AD-MSCs led to a significant improvement of the WOMAC score at 6 months. In the control group, there was no significant change in the WOMAC score at 6 months. No serious adverse events were observed in both groups during the follow-up period. In MRI, there was no significant change of cartilage defect at 6 months in MSC group whereas the defect in the control group was increased. An intra-articular injection of autologous AD-MSCs provided satisfactory functional improvement and pain relief for patients with knee osteoarthritis in the outpatient setting, without causing adverse events at 6 months\u2019 follow-up. Larger sample size and long-term follow-up are required. Stem Cells Translational Medicine \u00a02019;8:504\u2013511<\/jats:p>\n               <jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>","DOI":"10.1002\/sctm.18-0122","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T19:55:13Z","timestamp":1551815713000},"page":"504-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":446,"title":["Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial"],"prefix":"10.1093","volume":"8","author":[{"given":"Woo-Suk","family":"Lee","sequence":"first","affiliation":[{"name":"a Department of Orthopaedic Surgery, College of Medicine, Gangnam Severance Hospital Yonsei University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"b Department of Orthopaedic Surgery, Center for Joint Diseases and Rheumatism Kyung Hee University Hospital at Gangdong, Seoul, South Korea"},{"name":"c School of Medicine Kyung Hee University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Il","family":"Kim","sequence":"additional","affiliation":[{"name":"b Department of Orthopaedic Surgery, Center for Joint Diseases and Rheumatism Kyung Hee University Hospital at Gangdong, Seoul, South Korea"},{"name":"c School of Medicine Kyung Hee University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Beom","family":"Kim","sequence":"additional","affiliation":[{"name":"b Department of Orthopaedic Surgery, Center for Joint Diseases and Rheumatism Kyung Hee University Hospital at Gangdong, Seoul, South Korea"},{"name":"c School of Medicine Kyung Hee University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook","family":"Jin","sequence":"additional","affiliation":[{"name":"d Department of Radiology Kyung Hee University Hospital at Gangdong, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"2022022810170154800_sct312475-bib-0001","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1097\/TP.0b013e318291a2da","article-title":"Treatment of knee osteoarthritis with autologous mesenchymal stem cells: A pilot study","volume":"95","author":"Orozco","year":"2013","journal-title":"Transplantation"},{"key":"2022022810170154800_sct312475-bib-0002","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/stem.1634","article-title":"Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: A proof-of-concept clinical trial","volume":"32","author":"Jo","year":"2014","journal-title":"Stem Cells"},{"key":"2022022810170154800_sct312475-bib-0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coph.2014.01.005","article-title":"Stem cell treatment for musculoskeletal disease","volume":"16","author":"Carstairs","year":"2014","journal-title":"Curr Opin Pharmacol"},{"key":"2022022810170154800_sct312475-bib-0004","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12891-016-1085-9","article-title":"Mesenchymal stem cell therapy in the treatment of osteoarthritis: Reparative pathways, safety and efficacy\u2014A review","volume":"17","author":"Freitag","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"2022022810170154800_sct312475-bib-0005","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.joca.2013.06.025","article-title":"Safety of intra-articular cell-therapy with culture-expanded stem cells in humans: A systematic literature review","volume":"21","author":"Peeters","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"2022022810170154800_sct312475-bib-0006","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrrheum.2013.109","article-title":"Mesenchymal stem cells in joint disease and repair","volume":"9","author":"Barry","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"2022022810170154800_sct312475-bib-0007","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.joca.2012.06.002","article-title":"Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen","volume":"20","author":"Horie","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"2022022810170154800_sct312475-bib-0008","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/path.2469","article-title":"Why are MSCs therapeutic? 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