{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:33:00Z","timestamp":1793298780167,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":900,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The main objective of this phase I trial was to assess the feasibility and safety of microtransplanting human neural stem cell (hNSC) lines into the spinal cord of patients with amyotrophic lateral sclerosis (ALS). Eighteen patients with a definite diagnosis of ALS received microinjections of hNSCs into the gray matter tracts of the lumbar or cervical spinal cord. Patients were monitored before and after transplantation by clinical, psychological, neuroradiological, and neurophysiological assessment. For up to 60\u2009months after surgery, none of the patients manifested severe adverse effects or increased disease progression because of the treatment. Eleven patients died, and two underwent tracheotomy as a result of the natural history of the disease. We detected a transitory decrease in progression of ALS Functional Rating Scale Revised, starting within the first month after surgery and up to 4\u2009months after transplantation. Our results show that transplantation of hNSC is a safe procedure that causes no major deleterious effects over the short or long term. This study is the first example of medical transplantation of a highly standardized cell drug product, which can be reproducibly and stably expanded ex vivo, comprising hNSC that are not immortalized, and are derived from the forebrain of the same two donors throughout this entire study as well as across future trials. Our experimental design provides benefits in terms of enhancing both intra- and interstudy reproducibility and homogeneity. Given the potential therapeutic effects of the hNSCs, our observations support undertaking future phase II clinical studies in which increased cell dosages are studied in larger cohorts of patients. Stem Cells Translational Medicine \u00a02019;8:887\u2013897<\/jats:p>\n                  <jats:sec>\n                    <jats:title\/>\n                  <\/jats:sec>","DOI":"10.1002\/sctm.18-0154","type":"journal-article","created":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T00:15:17Z","timestamp":1558224917000},"page":"887-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["Results from Phase I Clinical Trial with Intraspinal Injection of Neural Stem Cells in Amyotrophic Lateral Sclerosis: A Long-Term Outcome"],"prefix":"10.1093","volume":"8","author":[{"given":"Letizia","family":"Mazzini","sequence":"first","affiliation":[{"name":"a Eastern Piedmont University, \u201cMaggiore della Carit\u00e0\u201d Hospital Dipartimento di Neurologia, Novara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Gelati","sequence":"additional","affiliation":[{"name":"b Laboratorio Cellule Staminali Cell Factory e Biobanca, Terni Hospital, Italy"},{"name":"c Fondazione IRCCS Casa Sollievo della Sofferenza Advanced Therapies Production Unit, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Celeste","family":"Profico","sequence":"additional","affiliation":[{"name":"c Fondazione IRCCS Casa Sollievo della Sofferenza Advanced Therapies Production Unit, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Sorar\u00f9","sequence":"additional","affiliation":[{"name":"d Department of Neuroscience University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ferrari","sequence":"additional","affiliation":[{"name":"e Biotechnology and Bioscience Department Bicocca University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Copetti","sequence":"additional","affiliation":[{"name":"f Fondazione IRCCS Casa Sollievo della Sofferenza Biostatistic Unit, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Muzi","sequence":"additional","affiliation":[{"name":"b Laboratorio Cellule Staminali Cell Factory e Biobanca, Terni Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ricciolini","sequence":"additional","affiliation":[{"name":"b Laboratorio Cellule Staminali Cell Factory e Biobanca, Terni Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Carletti","sequence":"additional","affiliation":[{"name":"g Department of Neurosurgery and Neuroscience \u201cSanta Maria\u201d Hospital, Terni, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Giorgi","sequence":"additional","affiliation":[{"name":"g Department of Neurosurgery and Neuroscience \u201cSanta Maria\u201d Hospital, Terni, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Spera","sequence":"additional","affiliation":[{"name":"g Department of Neurosurgery and Neuroscience \u201cSanta Maria\u201d Hospital, Terni, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Frondizi","sequence":"additional","affiliation":[{"name":"g Department of Neurosurgery and Neuroscience \u201cSanta Maria\u201d Hospital, Terni, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Masiero","sequence":"additional","affiliation":[{"name":"d Department of Neuroscience University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Stecco","sequence":"additional","affiliation":[{"name":"h Department of Diagnostic and Interventional Radiology \u201cEastern Piedmont\u201d University, \u201cMaggiore della Carit\u00e0\u201d Hospital, Novara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Cisari","sequence":"additional","affiliation":[{"name":"i Department of Physical Therapy \u201cEastern Piedmont\u201d University, \u201cMaggiore della Carit\u00e0\u201d Hospital, Novara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Bersano","sequence":"additional","affiliation":[{"name":"a Eastern Piedmont University, \u201cMaggiore della Carit\u00e0\u201d Hospital Dipartimento di Neurologia, Novara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"De Marchi","sequence":"additional","affiliation":[{"name":"a Eastern Piedmont University, \u201cMaggiore della Carit\u00e0\u201d Hospital Dipartimento di Neurologia, Novara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Francesca","family":"Sarnelli","sequence":"additional","affiliation":[{"name":"a Eastern Piedmont University, \u201cMaggiore della Carit\u00e0\u201d Hospital Dipartimento di Neurologia, Novara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Querin","sequence":"additional","affiliation":[{"name":"d Department of Neuroscience University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cantello","sequence":"additional","affiliation":[{"name":"a Eastern Piedmont University, \u201cMaggiore della Carit\u00e0\u201d Hospital Dipartimento di Neurologia, Novara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Petruzzelli","sequence":"additional","affiliation":[{"name":"j Fondazione IRCCS Casa Sollievo della Sofferenza Obstetrics and Gynaecology Department, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Maglione","sequence":"additional","affiliation":[{"name":"j Fondazione IRCCS Casa Sollievo della Sofferenza Obstetrics and Gynaecology Department, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Zalfa","sequence":"additional","affiliation":[{"name":"e Biotechnology and Bioscience Department Bicocca University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Binda","sequence":"additional","affiliation":[{"name":"k Fondazione IRCCS Casa Sollievo della Sofferenza Cancer Stem Cells Unit, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Visioli","sequence":"additional","affiliation":[{"name":"l StemGen SpA, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Trombetta","sequence":"additional","affiliation":[{"name":"m Fondazione IRCCS Casa Sollievo della Sofferenza Department of Oncology, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Torres","sequence":"additional","affiliation":[{"name":"n Fondazione IRCCS Casa Sollievo della Sofferenza Cytogenetics Unit, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bernardini","sequence":"additional","affiliation":[{"name":"n Fondazione IRCCS Casa Sollievo della Sofferenza Cytogenetics Unit, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Gaiani","sequence":"additional","affiliation":[{"name":"d Department of Neuroscience University of Padua, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurilio","family":"Massara","sequence":"additional","affiliation":[{"name":"a Eastern Piedmont University, \u201cMaggiore della Carit\u00e0\u201d Hospital Dipartimento di Neurologia, Novara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Paolucci","sequence":"additional","affiliation":[{"name":"a Eastern Piedmont University, \u201cMaggiore della Carit\u00e0\u201d Hospital Dipartimento di Neurologia, Novara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Boulis","sequence":"additional","affiliation":[{"name":"o Department of Neurosurgery Emory University, Atlanta, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo L.","family":"Vescovi","sequence":"additional","affiliation":[{"name":"b Laboratorio Cellule Staminali Cell Factory e Biobanca, Terni Hospital, Italy"},{"name":"c Fondazione IRCCS Casa Sollievo della Sofferenza Advanced Therapies Production Unit, San Giovanni Rotondo, Foggia, Italy"},{"name":"e Biotechnology and Bioscience Department Bicocca University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the ALS-NSCs Trial Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,18]]},"reference":[{"key":"2022022810501170300_sct312506-bib-0001","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1056\/NEJMra1603471","article-title":"Amyotrophic Lateral Sclerosis","volume":"377","author":"Brown","year":"2017","journal-title":"N Engl J Med"},{"key":"2022022810501170300_sct312506-bib-0002","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1056\/NEJM199403033300901","article-title":"A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS\/Riluzole Study Group","volume":"330","author":"Bensimon","year":"1994","journal-title":"N Engl J Med"},{"key":"2022022810501170300_sct312506-bib-0003","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1474-4422(17)30115-1","article-title":"Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: A randomised, double-blind, placebo-controlled trial","volume":"16","author":"Group W, Group EM-AS","year":"2017","journal-title":"Lancet Neurol"},{"key":"2022022810501170300_sct312506-bib-0004","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1172\/JCI40543","article-title":"Stem cells in human neurodegenerative disorders--time for clinical translation?","volume":"120","author":"Lindvall","year":"2010","journal-title":"J Clin Invest"},{"key":"2022022810501170300_sct312506-bib-0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/exnr.1998.6998","article-title":"Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation","volume":"156","author":"Vescovi","year":"1999","journal-title":"Exp Neurol"},{"key":"2022022810501170300_sct312506-bib-0006","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00018-011-0873-5","article-title":"Differential pathotropism of non-immortalized and immortalized human neural stem cell lines in a focal demyelination model","volume":"69","author":"Ferrari","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"2022022810501170300_sct312506-bib-0007","doi-asserted-by":"crossref","first-page":"e14035","DOI":"10.1371\/journal.pone.0014035","article-title":"Long-term survival of human neural stem cells in the ischemic rat brain upon transient immunosuppression","volume":"5","author":"Rota Nodari","year":"2010","journal-title":"PLoS One"},{"key":"2022022810501170300_sct312506-bib-0008","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/stem.1079","article-title":"Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: Results of a phase I trial in 12 patients","volume":"30","author":"Glass","year":"2012","journal-title":"Stem Cells"},{"key":"2022022810501170300_sct312506-bib-0009","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12967-014-0371-2","article-title":"Human neural stem cell transplantation in ALS: Initial results from a phase I trial","volume":"13","author":"Mazzini","year":"2015","journal-title":"J Transl Med"},{"key":"2022022810501170300_sct312506-bib-0010","first-page":"293","article-title":"Amyotroph Lateral Scler Other Motor Neuron Disorder","volume-title":"Diseases","author":"Brooks","year":"2000"},{"key":"2022022810501170300_sct312506-bib-0011","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0022-510X(99)00209-9","article-title":"Consensus guidelines for the design and implementation of clinical trials in ALS. World Federation of Neurology committee on Research","volume":"169","author":"Miller","year":"2009","journal-title":"J Neurol Sci"},{"key":"2022022810501170300_sct312506-bib-0012","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1353\/ken.2014.0017","article-title":"The risk-escalation model: A principled design strategy for early-phase trials","volume":"24","author":"Hey","year":"2014","journal-title":"Kennedy Inst Ethics J"},{"key":"2022022810501170300_sct312506-bib-0013","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/(SICI)1097-4598(200006)23:6<874::AID-MUS5>3.0.CO;2-U","article-title":"Linear estimates of disease progression predict survival in patients with amyotrophic lateral sclerosis","volume":"23","author":"Armon","year":"2000","journal-title":"Muscle Nerve"},{"key":"2022022810501170300_sct312506-bib-0014","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/mus.21354","article-title":"A placebo arm is not always necessary in clinical trials of amyotrophic lateral sclerosis","volume":"39","author":"Gordon","year":"2009","journal-title":"Muscle Nerve"},{"key":"2022022810501170300_sct312506-bib-0015","volume-title":"Revised Manual for the Profile of Mood States","author":"McNair","year":"1992"},{"key":"2022022810501170300_sct312506-bib-0016","volume-title":"The Schedule for the Evaluation of Individual Quality of Life (SEIQoL): A Direct Weighting Procedure for Quality of Life Domains (SEIQoL-DW)","author":"O'Boyle","year":"1993"},{"key":"2022022810501170300_sct312506-bib-0017","article-title":"Cell-based therapies for amyotrophic lateral sclerosis\/motor neuron disease","volume":"8","author":"Abdul Wahid","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2022022810501170300_sct312506-bib-0018","doi-asserted-by":"crossref","first-page":"298","DOI":"10.5966\/sctm.2011-0045","article-title":"Concise review: self-renewal in the central nervous system: Neural stem cells from embryo to adult","volume":"1","author":"De Filippis","year":"2012","journal-title":"Stem Cells Translational Medicine"},{"key":"2022022810501170300_sct312506-bib-0019","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/ana.24113","article-title":"Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: Phase 1 trial outcomes","volume":"75","author":"Feldman","year":"2014","journal-title":"Ann Neurol"},{"key":"2022022810501170300_sct312506-bib-0020","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1212\/WNL.0000000000002889","article-title":"Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials","volume":"87","author":"Glass","year":"2016","journal-title":"Neurol"},{"key":"2022022810501170300_sct312506-bib-0021","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/acn3.567","article-title":"Long-term Phase 1\/2 intraspinal stem cell transplantation outcomes in ALS","volume":"5","author":"Goutman","year":"2018","journal-title":"Ann Clin Transl Neurol"},{"key":"2022022810501170300_sct312506-bib-0022","doi-asserted-by":"crossref","first-page":"165ra164","DOI":"10.1126\/scitranslmed.3004579","article-title":"Multimodal actions of neural stem cells in a mouse model of ALS: A meta-analysis","volume":"4","author":"Teng","year":"2012","journal-title":"Sci Transl Med"},{"key":"2022022810501170300_sct312506-bib-0023","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/ana.21745","article-title":"Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates","volume":"66","author":"Pluchino","year":"2009","journal-title":"Ann Neurol"},{"key":"2022022810501170300_sct312506-bib-0024","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0896-6273(93)90124-A","article-title":"bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal\/astroglial) EGF-generated CNS progenitor cells","volume":"11","author":"Vescovi","year":"1993","journal-title":"Neuron"},{"key":"2022022810501170300_sct312506-bib-0025","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-62703-574-3_6","article-title":"Culturing and expansion of \"clinical grade\" precursors cells from the fetal human central nervous system","volume":"1059","author":"Gelati","year":"2013","journal-title":"Methods Mol Biol"},{"key":"2022022810501170300_sct312506-bib-0026","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1517\/14712598.2016.1116516","article-title":"Stem cells therapy for ALS","volume":"16","author":"Mazzini","year":"2016","journal-title":"Expert Opin Biol Ther"},{"key":"2022022810501170300_sct312506-bib-0027","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.neuroscience.2013.07.022","article-title":"Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neural and oligodendroglial differentiation of human neural precursor cells in vitro","volume":"250","author":"Cristofanilli","year":"2013","journal-title":"Neuroscience"},{"key":"2022022810501170300_sct312506-bib-0028","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1021\/acs.jproteome.5b00804","article-title":"Label-free LC-MS\/MS proteomic analysis of cerebrospinal fluid identifies protein\/pathway alterations and candidate biomarkers for amyotrophic lateral sclerosis","volume":"14","author":"Collins","year":"2015","journal-title":"J Proteome Res"},{"key":"2022022810501170300_sct312506-bib-0029","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature02544","article-title":"VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model","volume":"429","author":"Azzouz","year":"2004","journal-title":"Nature"},{"key":"2022022810501170300_sct312506-bib-0030","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ana.20223","article-title":"Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS","volume":"56","author":"Zheng","year":"2004","journal-title":"Ann Neurol"},{"key":"2022022810501170300_sct312506-bib-0031","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.bbrc.2007.09.088","article-title":"VEGF reduces astrogliosis and preserves neuromuscular junctions in ALS transgenic mice","volume":"363","author":"Zheng","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"2022022810501170300_sct312506-bib-0032","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1742-2094-8-47","article-title":"Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in amyotrophic lateral sclerosis (ALS) patients","volume":"8","author":"Gupta","year":"2011","journal-title":"J Neuroinflammation"},{"key":"2022022810501170300_sct312506-bib-0033","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0169-328X(03)00025-1","article-title":"VEGF-induced activation of the PI3-K\/Akt pathway reduces mutant SOD1-mediated motor neuron cell death","volume":"111","author":"Li","year":"2003","journal-title":"Brain Res Mol Brain Res"},{"key":"2022022810501170300_sct312506-bib-0034","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2353\/ajpath.2010.090798","article-title":"Progressive secondary neurodegeneration and microcalcification co-occur in osteopontin-deficient mice","volume":"177","author":"Maetzler","year":"2010","journal-title":"Am J Pathol"},{"key":"2022022810501170300_sct312506-bib-0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neulet.2012.05.048","article-title":"CD44 expression in astrocytes and microglia is associated with ALS progression in a mouse model","volume":"520","author":"Matsumoto","year":"2012","journal-title":"Neurosci Lett"},{"key":"2022022810501170300_sct312506-bib-0036","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1523\/JNEUROSCI.4805-06.2007","article-title":"Osteopontin-deficient mice exhibit less inflammation, greater tissue damage, and impaired locomotor recovery from spinal cord injury compared with wild-type controls","volume":"27","author":"Hashimoto","year":"2007","journal-title":"J Neurosci"},{"key":"2022022810501170300_sct312506-bib-0037","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.nbd.2006.10.020","article-title":"Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model","volume":"25","author":"Maetzler","year":"2007","journal-title":"Neurobiol Dis"},{"key":"2022022810501170300_sct312506-bib-0038","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ijdevneu.2012.04.003","article-title":"Osteopontin increases the proliferation of neural progenitor cells","volume":"30","author":"Kalluri","year":"2012","journal-title":"Int J Dev Neurosci"},{"key":"2022022810501170300_sct312506-bib-0039","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1056\/NEJMc1600188","article-title":"Glioproliferative lesion of the spinal cord as a complication of \"stem-cell tourism\"","volume":"375","author":"Berkowitz","year":"2016","journal-title":"N Engl J Med"},{"key":"2022022810501170300_sct312506-bib-0040","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1681\/ASN.2009111156","article-title":"Angiomyeloproliferative lesions following autologous stem cell therapy","volume":"21","author":"Thirabanjasak","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"2022022810501170300_sct312506-bib-0041","doi-asserted-by":"crossref","first-page":"e1000029","DOI":"10.1371\/journal.pmed.1000029","article-title":"Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient","volume":"6","author":"Amariglio","year":"2009","journal-title":"PLoS Med"},{"key":"2022022810501170300_sct312506-bib-0042","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.jcyt.2016.08.005","article-title":"Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?","volume":"18","author":"Atassi","year":"2016","journal-title":"Cytotherapy"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsctm.18-0154","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sctm.18-0154","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/sctm.18-0154","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/8\/9\/887\/42624097\/stcltm_8_9_887.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/8\/9\/887\/42624097\/stcltm_8_9_887.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T05:56:56Z","timestamp":1646027816000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/8\/9\/887\/6403799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,18]]},"references-count":42,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,5,18]]},"published-print":{"date-parts":[[2019,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/sctm.18-0154","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,9,1]]},"published":{"date-parts":[[2019,5,18]]},"assertion":[{"value":"2018-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}