{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:01:54Z","timestamp":1790434914506,"version":"4.1.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":951,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","award":["UMRS976"],"award-info":[{"award-number":["UMRS976"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"name":"HLA et M\u00e9dicine"},{"name":"LABEX TRANSPLANTEX","award":["ANR-11-LABX-0070"],"award-info":[{"award-number":["ANR-11-LABX-0070"]}]},{"name":"European grant","award":["FP7-HEALTH-242038-CAREMI"],"award-info":[{"award-number":["FP7-HEALTH-242038-CAREMI"]}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["UMRS976"],"award-info":[{"award-number":["UMRS976"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The positive effects of therapeutic human allogeneic cardiac stem\/progenitor cells (hCPC) in terms of cardiac repair\/regeneration are very likely mediated by paracrine effects. Our previous studies revealed the advantageous immune interactions of allogeneic hCPC and proposed them as part of the positive paracrine effects occurring upon their application postmyocardial infarction (MI). Currently, extracellular vesicles\/exosomes (EV\/Exs) released by stem\/progenitor cells are also proposed as major mediators of paracrine effects of therapeutic cells. Along this line, we evaluated contribution of EV\/Exs released by therapeutic hCPC to the benefit of their successful allogeneic clinical application. Through tailored allogeneic in vitro human assay models mimicking the clinical setting, we demonstrate that hCPC-released EV\/Exs were rapidly and efficiently up-taken by chief cellular actors of cardiac repair\/regeneration. This promoted MAPK\/Erk1\/2 activation, migration, and proliferation of human leukocyte antigens (HLA)-mismatched hCPC, mimicking endogenous progenitor cells and cardiomyocytes, and enhanced endothelial cell migration, growth, and organization into tube-like structures through activation of several signaling pathways. EV\/Exs also acted as pro-survival stimuli for HLA-mismatched monocytes tuning their phenotype toward an intermediate anti-inflammatory pro-angiogenic phenotype. Thus, while positively impacting the intrinsic regenerative and angiogenic programs, EV\/Exs released by therapeutic allogeneic hCPC can also actively contribute to shaping MI-inflammatory environment, which could strengthen the benefits of hCPC allogeneic interactions. Collectively, our data might forecast the application of allogeneic hCPC followed by their cell-free EV\/Exs as a strategy that will not only elicit the cell-contact mediated reparative\/regenerative immune response but also have the desired long-lasting effects through the EV\/Exs. Stem Cells Translational Medicine \u00a02019;8:911\u2013924<\/jats:p>\n               <jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>","DOI":"10.1002\/sctm.18-0256","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T04:11:20Z","timestamp":1553832680000},"page":"911-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Extracellular Vesicles Released by Allogeneic Human Cardiac Stem\/Progenitor Cells as Part of Their Therapeutic Benefit"],"prefix":"10.1093","volume":"8","author":[{"given":"Hocine Rachid","family":"Hocine","sequence":"first","affiliation":[{"name":"a Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMRS-976 Universit\u00e9 Paris-Diderot, H\u00f4pital Saint-Louis, Paris, France"},{"name":"b HLA et M\u00e9decine, Labex Transplantex H\u00f4pital Saint Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Brunel","sequence":"additional","affiliation":[{"name":"a Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMRS-976 Universit\u00e9 Paris-Diderot, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"c Centre of Pathophysiology Toulouse Purpan INSERM U1043, CNRS UMR5282, Toulouse III University, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Giustiniani","sequence":"additional","affiliation":[{"name":"a Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMRS-976 Universit\u00e9 Paris-Diderot, H\u00f4pital Saint-Louis, Paris, France"},{"name":"d Institut Jean Godinot, Unicancer, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabel Jouve","family":"San Roman","sequence":"additional","affiliation":[{"name":"e Institut Curie UMR3215, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann J.","family":"Ferrat","sequence":"additional","affiliation":[{"name":"f CERAG Laboratory University of Grenoble Alpes, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Palacios","sequence":"additional","affiliation":[{"name":"g Tigenix, Tres Cantos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Rosa","sequence":"additional","affiliation":[{"name":"h Cortherapix SLU Tigenix Group, Tres Cantos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleuterio","family":"Lombardo","sequence":"additional","affiliation":[{"name":"g Tigenix, Tres Cantos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Bensussan","sequence":"additional","affiliation":[{"name":"a Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMRS-976 Universit\u00e9 Paris-Diderot, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Charron","sequence":"additional","affiliation":[{"name":"a Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMRS-976 Universit\u00e9 Paris-Diderot, H\u00f4pital Saint-Louis, Paris, France"},{"name":"b HLA et M\u00e9decine, Labex Transplantex H\u00f4pital Saint Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Jabrane-Ferrat","sequence":"additional","affiliation":[{"name":"c Centre of Pathophysiology Toulouse Purpan INSERM U1043, CNRS UMR5282, Toulouse III University, Toulouse, 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