{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:32:59Z","timestamp":1790199179908,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":945,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"NIHR Biomedical Research Centre"},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P01660X\/1"],"award-info":[{"award-number":["MR\/P01660X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Apollo Therapeutics","award":["AP02"],"award-info":[{"award-number":["AP02"]}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P01660X\/1"],"award-info":[{"award-number":["MR\/P01660X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Glaucoma is one of the leading causes of blindness, and there is an ongoing need for new therapies. Recent studies indicate that cell transplantation using M\u00fcller glia may be beneficial, but there is a need for novel sources of cells to provide therapeutic benefit. In this study, we have isolated M\u00fcller glia from retinal organoids formed by human induced pluripotent stem cells (hiPSCs) in vitro and have shown their ability to partially restore visual function in rats depleted of retinal ganglion cells by NMDA. Based on the present results, we suggest that M\u00fcller glia derived from retinal organoids formed by hiPSC may provide an attractive source of cells for human retinal therapies, to prevent and treat vision loss caused by retinal degenerative conditions. Stem Cells Translational Medicine \u00a02019;8:775\u2013784<\/jats:p>\n               <jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>","DOI":"10.1002\/sctm.18-0263","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T01:56:16Z","timestamp":1556675776000},"page":"775-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Phenotypic and Functional Characterization of M\u00fcller Glia Isolated from Induced Pluripotent Stem Cell-Derived Retinal Organoids: Improvement of Retinal Ganglion Cell Function upon Transplantation"],"prefix":"10.1093","volume":"8","author":[{"given":"Karen","family":"Eastlake","sequence":"first","affiliation":[{"name":"a NIHR Biomedical Research Centre UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Wang","sequence":"additional","affiliation":[{"name":"a NIHR Biomedical Research Centre UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Jayaram","sequence":"additional","affiliation":[{"name":"a NIHR Biomedical Research Centre UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Murray-Dunning","sequence":"additional","affiliation":[{"name":"a NIHR Biomedical Research Centre UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J. F.","family":"Carr","sequence":"additional","affiliation":[{"name":"a NIHR Biomedical Research Centre UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor M.","family":"Ramsden","sequence":"additional","affiliation":[{"name":"a NIHR Biomedical Research Centre UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Vugler","sequence":"additional","affiliation":[{"name":"a NIHR Biomedical Research Centre UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Gore","sequence":"additional","affiliation":[{"name":"b Apollo Therapeutics, Stevenage, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Clemo","sequence":"additional","affiliation":[{"name":"b Apollo Therapeutics, Stevenage, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Stewart","sequence":"additional","affiliation":[{"name":"a NIHR Biomedical Research Centre UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete","family":"Coffey","sequence":"additional","affiliation":[{"name":"a NIHR Biomedical Research Centre UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng T.","family":"Khaw","sequence":"additional","affiliation":[{"name":"a NIHR Biomedical Research Centre UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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