{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:57:48Z","timestamp":1792789068281,"version":"4.5.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":707,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005834","name":"Francis Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005834","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UTHSCSA School of Medicine Clinical Investigator Kickstart Pilot Grant"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR001118"],"award-info":[{"award-number":["KL2TR001118"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005834","name":"Francis Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR001118"],"award-info":[{"award-number":["KL2TR001118"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bronchopulmonary dysplasia (BPD) is a devastating lung condition that develops in premature newborns exposed to prolonged mechanical ventilation and supplemental oxygen. Significant morbidity and mortality are associated with this costly disease and effective therapies are limited. Mesenchymal stem\/stromal cells (MSCs) are multipotent cells that can repair injured tissue by secreting paracrine factors known to restore the function and integrity of injured lung epithelium and endothelium. Most preclinical studies showing therapeutic efficacy of MSCs for BPD are administered either intratracheally or intravenously. The purpose of this study was to examine the feasibility and effectiveness of human cord tissue-derived MSC administration given via the intranasal route. Human umbilical cord tissue MSCs were isolated, characterized, and given intranasally (500\u2009000 cells per 20\u2009\u03bcL) to a hyperoxia-induced rat model of BPD. Lung alveolarization, vascularization, and pulmonary vascular remodeling were restored in animals receiving MSC treatment. Gene and protein analysis suggest the beneficial effects of MSCs were attributed, in part, to a concerted effort targeting angiogenesis, immunomodulation, wound healing, and cell survival. These findings are clinically significant, as neonates who develop BPD have altered alveolar development, decreased pulmonary vascularization and chronic inflammation, all resulting in impaired tissue healing. Our study is the first to report the intranasal delivery of umbilical cord Wharton's jelly MSCs in experimental BPD is feasible, noninvasive, and an effective route that may bear clinical applicability.<\/jats:p>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Significance statement Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in extremely premature neonates. Unfortunately, current therapies for BPD are limited. Preclinical studies have shown that mesenchymal stem cell (MSC) treatment can restore alveolar growth, enhance vascular development, and stimulate tissue repair. Most of these studies have administered the cells via the intravenous\/tracheal route. Results of this study show, for the first time to the authors' knowledge, that the intranasal delivery of MSCs for BPD is effective in restoring lung alveolar growth and vascular development. Importantly, this study provides evidence that this noninvasive approach may be given separately or as an adjunct\/alternate to other routes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/sctm.18-0273","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T08:59:24Z","timestamp":1574845164000},"page":"221-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Intranasal delivery of human umbilical cord Wharton's jelly mesenchymal stromal cells restores lung alveolarization and vascularization in experimental bronchopulmonary dysplasia"],"prefix":"10.1093","volume":"9","author":[{"given":"Alvaro","family":"Moreira","sequence":"first","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlyn","family":"Winter","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooby","family":"Joy","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauryn","family":"Winter","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Jones","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Noronha","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Porter","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Quim","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Corral","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen","family":"Alayli","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyrelle","family":"Seno","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamimunisa","family":"Mustafa","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hornsby","sequence":"additional","affiliation":[{"name":"1 Department of Pediatrics, Cellular and Integrative Physiology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Ahuja","sequence":"additional","affiliation":[{"name":"2 Microbiology and Immunology University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"2022022809192121700_sct312626-bib-0001","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jpeds.2012.07.013","article-title":"Cost of morbidities in very low birth weight infants","volume":"162","author":"Johnson","year":"2013","journal-title":"J Pediatr"},{"key":"2022022809192121700_sct312626-bib-0002","author":"Martin","year":"2015"},{"key":"2022022809192121700_sct312626-bib-0003","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/MOP.0b013e3283423e6b","article-title":"The new bronchopulmonary dysplasia","volume":"23","author":"Jobe","year":"2011","journal-title":"Curr Opin Pediatr"},{"key":"2022022809192121700_sct312626-bib-0004","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1203\/PDR.0b013e3181256aeb","article-title":"Mechanical ventilation down-regulates surfactant protein a and keratinocyte growth factor expression in premature rabbits","volume":"62","author":"Digeronimo","year":"2007","journal-title":"Pediatr Res"},{"key":"2022022809192121700_sct312626-bib-0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1053\/j.semperi.2007.12.005","article-title":"Cardiopulmonary outcomes of extreme prematurity","volume":"32","author":"Doyle","year":"2008","journal-title":"Semin Perinatol"},{"key":"2022022809192121700_sct312626-bib-0006","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1164\/rccm.201412-2142PP","article-title":"Understanding the short- and long-term respiratory outcomes of prematurity and bronchopulmonary dysplasia","volume":"192","author":"Islam","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2022022809192121700_sct312626-bib-0007","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1001\/jama.289.9.1124","article-title":"Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms","volume":"289","author":"Schmidt","year":"2003","journal-title":"JAMA"},{"key":"2022022809192121700_sct312626-bib-0008","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fmed.2017.00061","article-title":"The future of bronchopulmonary dysplasia: emerging pathophysiological concepts and potential new avenues of treatment","volume":"4","author":"Collins","year":"2017","journal-title":"Front Med"},{"key":"2022022809192121700_sct312626-bib-0009","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1084-2756(02)00193-8","article-title":"Pathology of new bronchopulmonary dysplasia","volume":"8","author":"Coalson","year":"2003","journal-title":"Semin Neonatol"},{"key":"2022022809192121700_sct312626-bib-0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1053\/j.semperi.2006.05.003","article-title":"Pathogenesis of bronchopulmonary dysplasia","volume":"30","author":"Chess","year":"2006","journal-title":"Semin Perinatol"},{"key":"2022022809192121700_sct312626-bib-0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2217\/17460751.3.1.1","article-title":"A brief definition of regenerative medicine","volume":"3","author":"Mason","year":"2008","journal-title":"Regen Med"},{"key":"2022022809192121700_sct312626-bib-0012","first-page":"1","article-title":"Regenerative medicine\u2014fact sheet","author":"Hunziker","year":"2010","journal-title":"Natl Inst Health"},{"key":"2022022809192121700_sct312626-bib-0013","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.4049\/jimmunol.179.3.1855","article-title":"Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice","volume":"179","author":"Gupta","year":"2007","journal-title":"J Immunol"},{"key":"2022022809192121700_sct312626-bib-0014","doi-asserted-by":"crossref","first-page":"26211","DOI":"10.1074\/jbc.M110.119917","article-title":"Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1","volume":"285","author":"Fang","year":"2010","journal-title":"J Biol Chem"},{"key":"2022022809192121700_sct312626-bib-0015","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/bmt.2011.81","article-title":"Mesenchymal stromal cell therapy: a revolution in regenerative medicine?","volume":"47","author":"Bernardo","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"2022022809192121700_sct312626-bib-0016","first-page":"1","article-title":"Intratracheal transplantation of human umbilical cord blood derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats","volume":"12","author":"Chang","year":"2011","journal-title":"Cell Transplant"},{"key":"2022022809192121700_sct312626-bib-0017","doi-asserted-by":"crossref","first-page":"H1120","DOI":"10.1152\/ajpheart.00173.2006","article-title":"Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction","volume":"292","author":"Baber","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2022022809192121700_sct312626-bib-0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135574","article-title":"Optimal route for human umbilical cord blood-derived mesenchymal stem cell transplantation to protect against neonatal hyperoxic lung injury: gene expression profiles and histopathology","volume":"10","author":"Sung","year":"2015","journal-title":"PLoS One"},{"key":"2022022809192121700_sct312626-bib-0019","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/thoraxjnl-2012-202323","article-title":"Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia","volume":"68","author":"Pierro","year":"2013","journal-title":"Thorax"},{"key":"2022022809192121700_sct312626-bib-0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000489256","article-title":"Comparison of preterm and term Wharton's jelly-derived mesenchymal stem cell properties in different oxygen tensions","volume":"205","author":"Balgi-Agarwal","year":"2018","journal-title":"Cells Tissues Organs"},{"key":"2022022809192121700_sct312626-bib-0021","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/sctm.17-0126","article-title":"Mesenchymal stromal cell therapy in bronchopulmonary dysplasia: systematic review and meta-analysis of preclinical studies","volume":"6","author":"Augustine","year":"2017","journal-title":"Stem Cells Translational Medicine"},{"key":"2022022809192121700_sct312626-bib-0022","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.ajpath.2019.01.014","article-title":"Genetic strain and sex differences in a hyperoxia-induced mouse model of varying severity of bronchopulmonary dysplasia","volume":"189","author":"Leary","year":"2019","journal-title":"Am J Pathol"},{"key":"2022022809192121700_sct312626-bib-0023","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fmed.2015.00090","article-title":"Understanding the impact of infection, inflammation, and their persistence in the pathogenesis of bronchopulmonary dysplasia","volume":"2","author":"Balany","year":"2015","journal-title":"Front Med"},{"key":"2022022809192121700_sct312626-bib-0024","doi-asserted-by":"crossref","first-page":"L641","DOI":"10.1152\/ajplung.00023.2009","article-title":"Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity","volume":"297","author":"Yee","year":"2009","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"2022022809192121700_sct312626-bib-0025","doi-asserted-by":"crossref","first-page":"L936","DOI":"10.1152\/ajplung.00159.2014","article-title":"Animal models of bronchopulmonary dysplasia. The term mouse models","volume":"307","author":"Berger","year":"2014","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"2022022809192121700_sct312626-bib-0026","article-title":"Rodent identification II","author":"Stewart","year":"2017","journal-title":"J Vis Exp"},{"key":"2022022809192121700_sct312626-bib-0027","doi-asserted-by":"crossref","DOI":"10.3791\/4440","article-title":"Intranasal administration of CNS therapeutics to awake mice","author":"Hanson","year":"2013","journal-title":"J Vis Exp"},{"key":"2022022809192121700_sct312626-bib-0028","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejcb.2009.02.001","article-title":"Intranasal delivery of cells to the brain","volume":"88","author":"Danielyan","year":"2009","journal-title":"Eur J Cell Biol"},{"key":"2022022809192121700_sct312626-bib-0029","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/0963689718754561","article-title":"The route by which intranasally delivered stem cells enter the central nervous system","volume":"27","author":"Galeano","year":"2018","journal-title":"Cell Transplant"},{"key":"2022022809192121700_sct312626-bib-0030","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2217\/rme.14.26","article-title":"Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells","volume":"9","author":"Allard","year":"2014","journal-title":"Regen Med"},{"key":"2022022809192121700_sct312626-bib-0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006670","article-title":"Comparison of two quantitative methods of discerning airspace enlargement in smoke-exposed mice","volume":"4","author":"Jacob","year":"2009","journal-title":"PLoS One"},{"key":"2022022809192121700_sct312626-bib-0032","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3346\/jkms.2012.27.6.605","article-title":"Changes of gene expression after bone marrow cell transfusion in rats with monocrotaline-induced pulmonary hypertension","volume":"27","author":"Kim","year":"2012","journal-title":"J Korean Med Sci"},{"key":"2022022809192121700_sct312626-bib-0033","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/bmb.20461","article-title":"Real-time PCR (qPCR) primer design using free online software","volume":"39","author":"Thornton","year":"2011","journal-title":"Biochem Mol Biol Educ"},{"key":"2022022809192121700_sct312626-bib-0034","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1164\/rccm.200902-0179OC","article-title":"Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats","volume":"180","author":"Haaften","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"2022022809192121700_sct312626-bib-0035","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1007\/s00018-009-0027-1","article-title":"The annexins: spatial and temporal coordination of signaling events during cellular stress","volume":"66","author":"Monastyrskaya","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"2022022809192121700_sct312626-bib-0036","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1089\/ten.tea.2008.0414","article-title":"B-type natriuretic peptide enhances vasculogenesis by promoting number and functional properties of early endothelial progenitor cells","volume":"15","author":"Shmilovich","year":"2009","journal-title":"Tissue Eng Part A"},{"key":"2022022809192121700_sct312626-bib-0037","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1016\/j.ajpath.2014.08.010","article-title":"Intranasal versus intraperitoneal delivery of human umbilical cord tissue-derived cultured mesenchymal stromal cells in a murine model of neonatal lung injury","volume":"184","author":"Liu","year":"2014","journal-title":"Am J Pathol"},{"key":"2022022809192121700_sct312626-bib-0038","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1165\/rcmb.2008-0176OC","article-title":"Fate and effects of adult bone marrow cells in lungs of normoxic and hyperoxic newborn mice","volume":"40","author":"Fritzell","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2022022809192121700_sct312626-bib-0039","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1096\/fj.201700178R","article-title":"Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease","volume":"31","author":"Royce","year":"2017","journal-title":"FASEB J"},{"key":"2022022809192121700_sct312626-bib-0040","doi-asserted-by":"crossref","first-page":"L833","DOI":"10.1152\/ajplung.00173.2001","article-title":"Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia","volume":"282","author":"Southam","year":"2002","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"2022022809192121700_sct312626-bib-0041","article-title":"Intranasal delivery of VEGF enhances compensatory lung growth in mice","volume":"13","author":"Dao","year":"2018","journal-title":"PLoS One"},{"key":"2022022809192121700_sct312626-bib-0042","article-title":"Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: effect of instillation volume and form of Anesthesia","volume":"7","author":"Miller","year":"2012","journal-title":"PLoS One"},{"key":"2022022809192121700_sct312626-bib-0043","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.pharmthera.2012.03.003","article-title":"Intranasal drug delivery: an efficient and non-invasive route for systemic administration","volume":"134","author":"Grassin-Delyle","year":"2012","journal-title":"Pharmacol Ther"},{"key":"2022022809192121700_sct312626-bib-0044","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/mt.2013.199","article-title":"Intranasal delivery of mesenchymal stem cells significantly extends survival of irradiated mice with experimental brain tumors","volume":"22","author":"Balyasnikova","year":"2014","journal-title":"Mol Ther"},{"key":"2022022809192121700_sct312626-bib-0045","doi-asserted-by":"crossref","first-page":"866","DOI":"10.5966\/sctm.2012-0045","article-title":"Intranasal delivery of neural stem\/progenitor cells: a noninvasive passage to target intracerebral glioma","volume":"1","author":"Reitz","year":"2012","journal-title":"Stem Cells Translational Medicine"},{"key":"2022022809192121700_sct312626-bib-0046","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3727\/096368909X471189","article-title":"Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats","volume":"18","author":"Chang","year":"2009","journal-title":"Cell Transplant"},{"key":"2022022809192121700_sct312626-bib-0047","doi-asserted-by":"crossref","DOI":"10.1542\/neo.12-11-e645","article-title":"Pulmonary vascular disease and bronchopulmonary dysplasia: evaluation and treatment of pulmonary hypertension","volume":"12","author":"Abman","year":"2011","journal-title":"Neoreviews"},{"key":"2022022809192121700_sct312626-bib-0048","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1097\/PCC.0b013e3181c76cdc","article-title":"Neonatal pulmonary hypertension","volume":"11","author":"Steinhorn","year":"2010","journal-title":"Pediatr Crit Care Med"},{"key":"2022022809192121700_sct312626-bib-0049","doi-asserted-by":"crossref","first-page":"L959","DOI":"10.1152\/ajplung.00228.2014","article-title":"Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models","volume":"307","author":"D'Angio","year":"2014","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"2022022809192121700_sct312626-bib-0050","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jri.2017.09.013","article-title":"Pulmonary hypertension associated with bronchopulmonary dysplasia in preterm infants","volume":"124","author":"Bui","year":"2017","journal-title":"J Reprod Immunol"},{"key":"2022022809192121700_sct312626-bib-0051","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1165\/rcmb.2016-0031OC","article-title":"Airway remodeling and hyperreactivity in a model of bronchopulmonary dysplasia and their modulation by IL-1 receptor antagonist","volume":"55","author":"Royce","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2022022809192121700_sct312626-bib-0052","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1476-5381.2012.01827.x","article-title":"Endothelial actions of atrial and B-type natriuretic peptides","volume":"166","author":"Kuhn","year":"2012","journal-title":"Br J Pharmacol"},{"key":"2022022809192121700_sct312626-bib-0053","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1083\/jcb.201612122","article-title":"Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation","volume":"216","author":"Yao","year":"2017","journal-title":"J Cell Biol"},{"key":"2022022809192121700_sct312626-bib-0054","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1152\/physrev.00037.2014","article-title":"Membrane repair: mechanisms and pathophysiology","volume":"95","author":"Cooper","year":"2015","journal-title":"Physiol Rev"},{"key":"2022022809192121700_sct312626-bib-0055","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3390\/ijms19020591","article-title":"Functional association between regulatory RNAs and the annexins","volume":"19","author":"Monastyrskaya","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2022022809192121700_sct312626-bib-0056","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/ncomms1270","article-title":"Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair","volume":"2","author":"Bouter","year":"2011","journal-title":"Nat Commun"},{"key":"2022022809192121700_sct312626-bib-0057","doi-asserted-by":"crossref","first-page":"L354","DOI":"10.1152\/ajplung.00412.2006","article-title":"Glycosylation and annexin II cell surface translocation mediate airway epithelial wound repair","volume":"293","author":"Patchell","year":"2007","journal-title":"Am J Physiol Cell Mol Physiol"},{"key":"2022022809192121700_sct312626-bib-0058","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2011.04327.x","article-title":"Immunomodulatory properties and therapeutic application of mesenchymal stem cells","volume":"164","author":"Shi","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"2022022809192121700_sct312626-bib-0059","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.327","article-title":"Mesenchymal stem cells and immunomodulation: current status and future prospects","volume":"7","author":"Gao","year":"2016","journal-title":"Cell Death Dis"},{"key":"2022022809192121700_sct312626-bib-0060","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1161\/STROKEAHA.117.020465","article-title":"Stem cell-based immunomodulation after stroke: effects on brain repair processes","volume":"49","author":"Boshuizen","year":"2018","journal-title":"Stroke"},{"key":"2022022809192121700_sct312626-bib-0061","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1182\/blood-2007-02-069716","article-title":"Immunomodulatory properties of mesenchymal stromal cells","volume":"110","author":"Nauta","year":"2007","journal-title":"Blood"},{"key":"2022022809192121700_sct312626-bib-0062","article-title":"Timing of umbilical cord blood derived mesenchymal stem cells transplantation determines therapeutic efficacy in the neonatal hyperoxic lung injury","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS One"},{"key":"2022022809192121700_sct312626-bib-0063","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/ALN.0000000000000446","article-title":"Cell-based therapy for acute organ injury","volume":"121","author":"Monsel","year":"2014","journal-title":"Anesthesiology"},{"key":"2022022809192121700_sct312626-bib-0064","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/scrt428","article-title":"Microvesicles derived from human Wharton's jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1","volume":"5","author":"Zou","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"2022022809192121700_sct312626-bib-0065","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.cell.2018.11.010","article-title":"Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3","volume":"176","author":"Wang","year":"2019","journal-title":"Cell"},{"key":"2022022809192121700_sct312626-bib-0066","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3349\/ymj.2011.52.1.65","article-title":"Granulocyte colony stimulating factor attenuates hyperoxia-induced lung injury by down-modulating inflammatory responses in neonatal rats","volume":"52","author":"Jeon","year":"2011","journal-title":"Yonsei Med J"},{"key":"2022022809192121700_sct312626-bib-0067","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2353\/ajpath.2009.080345","article-title":"Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia","volume":"174","author":"Dempsey","year":"2009","journal-title":"Am J Pathol"},{"key":"2022022809192121700_sct312626-bib-0068","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S2213-2600(14)70217-6","article-title":"Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis","volume":"2","author":"Walter","year":"2014","journal-title":"Lancet Respir Med"},{"key":"2022022809192121700_sct312626-bib-0069","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1089\/wound.2014.0581","article-title":"Metalloproteinases and wound healing","volume":"4","author":"Caley","year":"2015","journal-title":"Adv Wound Care"},{"key":"2022022809192121700_sct312626-bib-0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jdermsci.2004.05.007","article-title":"Leukemia inhibitory factor-transfected embryonic fibroblasts and vascular endothelial growth factor successfully improve the skin substitute wound healing by increasing angiogenesis and matrix production","volume":"36","author":"Akita","year":"2004","journal-title":"J Dermatol Sci"},{"key":"2022022809192121700_sct312626-bib-0071","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12865-014-0041-4","article-title":"Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection","volume":"15","author":"Foronjy","year":"2014","journal-title":"BMC Immunol"},{"key":"2022022809192121700_sct312626-bib-0072","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/1479-5876-11-281","article-title":"Wound outcome in combat injuries is associated with a unique set of protein biomarkers","volume":"11","author":"Chromy","year":"2013","journal-title":"J Transl Med"},{"key":"2022022809192121700_sct312626-bib-0073","first-page":"1","article-title":"The role of the extracellular matrix components in cutaneous wound healing","volume":"2014","author":"Olczyk","year":"2014","journal-title":"Biomed Res Int"},{"key":"2022022809192121700_sct312626-bib-0074","doi-asserted-by":"crossref","first-page":"17010","DOI":"10.1038\/cddiscovery.2017.10","article-title":"Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis","volume":"3","author":"Kathiriya","year":"2017","journal-title":"Cell Death Discov"},{"key":"2022022809192121700_sct312626-bib-0075","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1016\/j.hlc.2017.06.207","article-title":"Fibulin-3 in cardiac fibrosis","volume":"26","author":"Mabotuwana","year":"2017","journal-title":"Hear Lung Circ"},{"key":"2022022809192121700_sct312626-bib-0076","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cellsig.2010.01.005","article-title":"WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death","volume":"22","author":"Venkatesan","year":"2010","journal-title":"Cell Signal"},{"key":"2022022809192121700_sct312626-bib-0077","doi-asserted-by":"crossref","first-page":"14414","DOI":"10.1074\/jbc.M809757200","article-title":"WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-\u03b1 (TNF-\u03b1)-stimulated cardiac fibroblast proliferation but inhibits TNF-\u03b1-induced cardiomyocyte death","volume":"284","author":"Venkatachalam","year":"2009","journal-title":"J Biol Chem"},{"key":"2022022809192121700_sct312626-bib-0078","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1091\/mbc.e04-01-0059","article-title":"The role of osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand in human microvascular endothelial cell survival","volume":"15","author":"Pritzker","year":"2004","journal-title":"Mol Biol Cell"},{"key":"2022022809192121700_sct312626-bib-0079","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2007-0017","article-title":"What can we learn from rodents about prolactin in humans?","volume":"29","author":"Ben-Jonathan","year":"2008","journal-title":"Endocr Rev"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sctm.18-0273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/sctm.18-0273","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/9\/2\/221\/42628513\/stcltm_9_2_221.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/9\/2\/221\/42628513\/stcltm_9_2_221.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T04:21:41Z","timestamp":1646022101000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/9\/2\/221\/6406774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,27]]},"references-count":79,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,11,27]]},"published-print":{"date-parts":[[2020,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/sctm.18-0273","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,2,1]]},"published":{"date-parts":[[2019,11,27]]},"assertion":[{"value":"2018-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}