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There are no available therapies to cure IVH, and standard treatment is supportive care. Unrestricted somatic stem cells (USSCs) from human cord blood have reparative effects in animal models of brain and spinal cord injuries. USSCs were administered to premature rabbit pups with IVH and their effects on white matter integrity and neurobehavioral performance were evaluated. USSCs were injected either via intracerebroventricular (ICV) or via intravenous (IV) routes in 3 days premature (term 32d) rabbit pups, 24\u2009hours after glycerol-induced IVH. The pups were sacrificed at postnatal days 3, 7, and 14 and effects were compared to glycerol-treated but unaffected or nontreated control. Using in vivo live bioluminescence imaging and immunohistochemical analysis, injected cells were found in the injured parenchyma on day 3 when using the IV route compared to ICV where cells were found adjacent to the ventricle wall forming aggregates; we did not observe any adverse events from either route of administration. The injected USSCs were functionally associated with attenuated microglial infiltration, less apoptotic cell death, fewer reactive astrocytes, and diminished levels of key inflammatory cytokines (TNF\u03b1 and IL1\u03b2). In addition, we observed better preservation of myelin fibers, increased myelin gene expression, and altered reactive astrocyte distribution in treated animals, and this was associated with improved locomotor function. Overall, our findings support the possibility that USSCs exert anti-inflammatory effects in the injured brain mitigating many detrimental consequences associated with IVH. Stem Cells Translational Medicine \u00a02019;8:1157\u20131169<\/jats:p>\n               <jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>","DOI":"10.1002\/sctm.19-0082","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T12:23:42Z","timestamp":1563539022000},"page":"1157-1169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Human Cord Blood-Derived Unrestricted Somatic Stem Cell Infusion Improves Neurobehavioral Outcome in a Rabbit Model of Intraventricular Hemorrhage"],"prefix":"10.1093","volume":"8","author":[{"given":"Govindaiah","family":"Vinukonda","sequence":"first","affiliation":[{"name":"a Department of Pediatrics New York Medical College, Valhalla, New York, USA"},{"name":"b Cell Biology & Anatomy, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Liao","sequence":"additional","affiliation":[{"name":"a Department of Pediatrics New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Hu","sequence":"additional","affiliation":[{"name":"a Department of Pediatrics New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Ivanova","sequence":"additional","affiliation":[{"name":"a Department of Pediatrics New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Purohit","sequence":"additional","affiliation":[{"name":"c The Regional Neonatal Center at Maria Fareri Children's Hospital of Westchester Medical Center, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina A.","family":"Finkel","sequence":"additional","affiliation":[{"name":"c The Regional Neonatal Center at Maria Fareri Children's Hospital of Westchester Medical Center, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadarshani","family":"Giri","sequence":"additional","affiliation":[{"name":"c The Regional Neonatal Center at Maria Fareri Children's Hospital of Westchester Medical Center, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmipramoda","family":"Bapatla","sequence":"additional","affiliation":[{"name":"b Cell Biology & Anatomy, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shetal","family":"Shah","sequence":"additional","affiliation":[{"name":"a Department of Pediatrics New York Medical College, Valhalla, New York, USA"},{"name":"c The Regional Neonatal Center at Maria Fareri Children's Hospital of Westchester Medical Center, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed T.","family":"Zia","sequence":"additional","affiliation":[{"name":"c The Regional Neonatal Center at Maria Fareri Children's Hospital of Westchester Medical Center, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hussein","sequence":"additional","affiliation":[{"name":"a Department of Pediatrics New York Medical College, Valhalla, New York, USA"},{"name":"c The Regional Neonatal Center at Maria Fareri Children's Hospital of Westchester Medical Center, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S.","family":"Cairo","sequence":"additional","affiliation":[{"name":"a Department of Pediatrics New York Medical College, Valhalla, New York, USA"},{"name":"b Cell Biology & Anatomy, New York Medical College, Valhalla, New York, USA"},{"name":"d Department of Medicine, Pathology, 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