{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:37:19Z","timestamp":1790638639913,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":643,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010308","name":"Field Neurosciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008576","name":"Central Michigan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010308","name":"Field Neurosciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008576","name":"Central Michigan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008576","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Huntington\u2019s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG repeat expansions in the huntingtin gene resulting in the synthesis of a misfolded form of the huntingtin protein (mHTT) which is toxic. The current treatments for HD are only palliative. Some of the potential therapies for HD include gene therapy (using antisense oligonucleotides and clustered regularly interspaced short palindromic repeats-Cas9 system) and stem-cell-based therapies. Various types of stem cell transplants, such as mesenchymal stem cells, neural stem cells, and reprogrammed stem cells, have the potential to either replace the lost neurons or support the existing neurons by releasing trophic factors. Most of the transplants are xenografts and allografts; however, recent reports on HD patients who received grafts suggest that the mHTT aggregates are transferred from the host neurons to the grafted cells as well as to the surrounding areas of the graft by a \u201cprion-like\u201d mechanism. This observation seems to be true for autotransplantation paradigms, as well. This article reviews the different types of stem cells that have been transplanted into HD patients and their therapeutic efficacy, focusing on the transfer of mHTT from the host cells to the graft. Autotransplants of reprogramed stem cells in HD patients are a promising therapeutic option. However, this needs further attention to ensure a better understanding of the transfer of mHTT aggregates following transplantation of the gene-corrected cells back into the patient.<\/jats:p>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p>Significance statement Stem cell transplantation, along with gene editing using a variety of molecular tools, is one of the most promising strategies that is being investigated by many researchers as a potential treatment for neurodegenerative diseases. Huntington\u2019s disease (HD) is one of the neurodegenerative diseases in which transplantation has been widely studied using different types of innate as well as reprogrammed\/modified stem cells as a potential therapy. Transplantation using different types of stem cells, such as mesenchymal stem cells, neural stem cells, embryonic stem cells, and induced pluripotent stem cells accompanied by clustered regularly interspaced short palindromic repeats-Cas9-based gene editing, was performed in laboratory settings, which could have an impact in the clinics in the near future. Though the treatment strategies had encouraging outcomes, one of the major issues identified recently was that mutant huntingtin protein aggregates transfer from the HD cells to the wild-type\/transplanted cells in the host brain, by a \u201cprion-like\u201d mechanism. The finding brings into question to what extent these stem cell\/gene-corrected cell transplants are a viable option for treating HD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/sctm.19-0248","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T08:39:17Z","timestamp":1580373557000},"page":"559-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prion-like mechanisms in neurodegenerative disease: Implications for Huntington\u2019s disease therapy"],"prefix":"10.1093","volume":"9","author":[{"given":"Bhairavi","family":"Srinageshwar","sequence":"first","affiliation":[{"name":"1 College of Medicine Central Michigan University, Mount Pleasant, Michigan"},{"name":"2 Field Neurosciences Institute Laboratory for Restorative Neurology Central Michigan University, Mount Pleasant, Michigan"},{"name":"3 Program in Neuroscience Central Michigan University, Mount Pleasant, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Petersen","sequence":"additional","affiliation":[{"name":"1 College of Medicine Central Michigan University, Mount Pleasant, Michigan"},{"name":"3 Program in Neuroscience Central Michigan University, Mount Pleasant, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Dunbar","sequence":"additional","affiliation":[{"name":"2 Field Neurosciences Institute Laboratory for Restorative Neurology Central Michigan University, Mount Pleasant, Michigan"},{"name":"3 Program in Neuroscience Central Michigan University, Mount Pleasant, Michigan"},{"name":"4 Department of Psychology Central Michigan University, Mount Pleasant, Michigan"},{"name":"5 Field Neurosciences Institute, Saginaw, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Rossignol","sequence":"additional","affiliation":[{"name":"1 College of Medicine Central 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