{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T22:36:14Z","timestamp":1771022174827,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":427,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"la Fondation Charles Bruneau"},{"DOI":"10.13039\/501100000156","name":"le r\u00e9seau Th\u00e9Cell from the Fonds de la recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","award":["#MOP-126096"],"award-info":[{"award-number":["#MOP-126096"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>It is still unclear if immune responses will compromise the large-scale utilization of human induced pluripotent stem cells (hiPSCs)-derived cell therapies. To answer this question, we used humanized mouse models generated by the adoptive transfer of peripheral blood mononuclear cells or the cotransplantation of hematopoietic stem cells and human thymic tissue. Using these mice, we evaluated the engraftment in skeletal muscle of myoblasts derived either directly from a muscle biopsy or differentiated from hiPSCs or fibroblasts. Our results showed that while allogeneic grafts were mostly rejected and highly infiltrated with human T\u2009cells, engraftment of autologous cells was tolerated. We also observed that hiPSC-derived myogenic progenitor cells (MPCs) are not targeted by autologous T\u2009cells and natural killer cells in\u2009vitro. These findings suggest that the reprogramming and differentiation procedures we used are not immunogenic and that hiPSC-derived MPCs will be tolerated in the presence of a competent human immune system.<\/jats:p>","DOI":"10.1002\/sctm.19-0452","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T03:40:14Z","timestamp":1599104414000},"page":"267-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Myogenic progenitor cells derived from human induced pluripotent stem cell are immune-tolerated in humanized mice"],"prefix":"10.1093","volume":"10","author":[{"given":"Basma","family":"Benabdallah","sequence":"first","affiliation":[{"name":"Centre de Recherche du CHU Ste-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"D\u00e9saulniers-Langevin","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU Ste-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Lyn","family":"Goyer","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU Ste-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chlo\u00e9","family":"Colas","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU Ste-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantale","family":"Maltais","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHUQ Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyi","family":"Li","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU Ste-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean V.","family":"Guimond","sequence":"additional","affiliation":[{"name":"CIUSSS du Centre-Sud-de-l'Ile-de-Montr\u00e9al, Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques P.","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHUQ Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elie","family":"Haddad","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU Ste-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"D\u00e9partement de P\u00e9diatrie, Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Beaus\u00e9jour","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU Ste-Justine, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"D\u00e9partement de 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