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A novel in vitro neurosphere culture has been established using fresh or frozen neural progenitor cells from newborn (PND0) rabbit brains. After surgical IUGR induction in pregnant rabbits and cesarean section 5\u2009days later, neural progenitor cells from both control and IUGR groups were isolated and directly cultured or frozen at \u221280\u00b0C. These neural progenitor cells spontaneously formed neurospheres after 7\u2009days in culture. The ability of control and IUGR neurospheres to migrate, proliferate, differentiate to neurons, astrocytes, or oligodendrocytes was compared and the possibility to modulate their responses was tested by exposure to several positive and negative controls. Neurospheres obtained from IUGR brains have a significant impairment in oligodendrocyte differentiation, whereas no significant differences are observed in other basic processes of neurogenesis. This impairment can be reverted by in vitro exposure of IUGR neurospheres to thyroid hormone, which is known to play an essential role in white matter maturation in vivo. Our new rabbit neurosphere model and the results of this study open the possibility to test several substances in vitro as neuroprotective candidates against IUGR induced neurodevelopmental damage while decreasing the number of animals and resources and allowing a more mechanistic approach at a cellular functional level.<\/jats:p>","DOI":"10.1002\/sctm.20-0223","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T08:22:07Z","timestamp":1602231727000},"page":"209-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction"],"prefix":"10.1093","volume":"10","author":[{"given":"Marta","family":"Barenys","sequence":"first","affiliation":[{"name":"IUF\u2014Leibniz Research Institute for Environmental Medicine, D\u00fcsseldorf, Germany"},{"name":"GRET, INSA-UB and 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