{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:16:04Z","timestamp":1791400564650,"version":"4.3.3"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001511","name":"Auckland Medical Research Foundation","doi-asserted-by":"publisher","award":["1211003"],"award-info":[{"award-number":["1211003"]}],"id":[{"id":"10.13039\/501100001511","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["16\/003"],"award-info":[{"award-number":["16\/003"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["17\/601"],"award-info":[{"award-number":["17\/601"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["12\/613"],"award-info":[{"award-number":["12\/613"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001511","name":"Auckland Medical Research Foundation","doi-asserted-by":"publisher","award":["1211003"],"award-info":[{"award-number":["1211003"]}],"id":[{"id":"10.13039\/501100001511","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["16\/003"],"award-info":[{"award-number":["16\/003"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["17\/601"],"award-info":[{"award-number":["17\/601"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["12\/613"],"award-info":[{"award-number":["12\/613"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>There is increasing evidence that administration of many types of stem cells, including human amnion epithelial cells (hAECs), can reduce hypoxic-ischemic injury, including in the perinatal brain. However, the therapeutic window for single dose treatment is not known. We compared the effects of early and delayed intracerebroventricular administration of hAECs in fetal sheep at 0.7 gestation on brain injury induced by 25\u2009minutes of complete umbilical cord occlusion (UCO) or sham occlusion. Fetuses received either 1\u2009\u00d7\u2009106 hAECs or vehicle alone, as an infusion over 1 hour, either 2 or 24\u2009hours after UCO. Fetuses were killed for brain histology at 7\u2009days post-UCO. hAEC infusion at both 2 and 24\u2009hours had dramatic anti-inflammatory and anti-gliotic effects, including significantly attenuating the increase in microglia after UCO in the white and gray matter and the number of astrocytes in the white matter. Both protocols partially improved myelination, but had no effect on total or immature\/mature numbers of oligodendrocytes. Neuronal survival in the hippocampus was increased by hAEC infusion at either 2 or 24\u2009hours, whereas only hAECs at 24\u2009hours were associated with improved neuronal survival in the striatum and thalamus. Neither protocol improved recovery of electroencephalographic (EEG) power. These data suggest that a single infusion of hAECs is anti-inflammatory, anti-gliotic, and neuroprotective in preterm fetal sheep when given up to 24\u2009hours after hypoxia-ischemia, but was associated with limited white matter protection after 7\u2009days recovery and no improvement in the recovery of EEG power.<\/jats:p>","DOI":"10.1002\/sctm.20-0314","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T09:30:24Z","timestamp":1603704624000},"page":"427-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Window of opportunity for human amnion epithelial stem cells to attenuate astrogliosis after umbilical cord occlusion in preterm fetal sheep"],"prefix":"10.1093","volume":"10","author":[{"given":"Joanne O.","family":"Davidson","sequence":"first","affiliation":[{"name":"Fetal Physiology and Neuroscience Group, Department of Physiology The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte G.","family":"Heuij","sequence":"additional","affiliation":[{"name":"Fetal Physiology and Neuroscience Group, Department of Physiology The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhoyra","family":"Fraser","sequence":"additional","affiliation":[{"name":"Fetal Physiology and Neuroscience Group, Department of Physiology The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Wassink","sequence":"additional","affiliation":[{"name":"Fetal Physiology and Neuroscience Group, Department of Physiology The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne L.","family":"Miller","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research, Clayton, Victoria, Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Lim","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research, Clayton, Victoria, Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euan M.","family":"Wallace","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research, Clayton, Victoria, Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Jenkin","sequence":"additional","affiliation":[{"name":"The Ritchie Centre Hudson Institute of Medical Research, Clayton, Victoria, Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair J.","family":"Gunn","sequence":"additional","affiliation":[{"name":"Fetal Physiology and Neuroscience Group, Department of Physiology The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bennet","sequence":"additional","affiliation":[{"name":"Fetal Physiology and Neuroscience Group, Department of Physiology The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"2022022810501900400_sct312854-bib-0001","volume-title":"Preterm Birth: Causes, Consequences, and Prevention","author":"Committee on Understanding Premature Birth and Assuring Healthy Outcomes","year":"2007"},{"key":"2022022810501900400_sct312854-bib-0002","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.pediatrneurol.2015.04.006","article-title":"Brain injury in the preterm infant: new horizons for pathogenesis and prevention","volume":"53","author":"Back","year":"2015","journal-title":"Pediatr Neurol"},{"key":"2022022810501900400_sct312854-bib-0003","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrneurol.2015.13","article-title":"The role of inflammation in perinatal brain injury","volume":"11","author":"Hagberg","year":"2015","journal-title":"Nat Rev Neurol"},{"key":"2022022810501900400_sct312854-bib-0004","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3389\/fneur.2020.00449","article-title":"A systematic review of magnesium sulfate for perinatal neuroprotection: what have we learnt from the past decade?","volume":"11","author":"Galinsky","year":"2020","journal-title":"Front Neurol"},{"key":"2022022810501900400_sct312854-bib-0005","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S1474-4422(15)00386-5","article-title":"Timing still key to treating hypoxic ischaemic brain injury","volume":"15","author":"Gunn","year":"2016","journal-title":"Lancet Neurol"},{"key":"2022022810501900400_sct312854-bib-0006","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000353948","article-title":"Time is brain: starting therapeutic hypothermia within three hours after birth improves motor outcome in asphyxiated newborns","volume":"104","author":"Thoresen","year":"2013","journal-title":"Neonatology"},{"key":"2022022810501900400_sct312854-bib-0007","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.siny.2010.05.007","article-title":"Potential biomarkers for hypoxic-ischemic encephalopathy","volume":"15","author":"Bennet","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"key":"2022022810501900400_sct312854-bib-0008","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fphar.2016.00196","article-title":"Blood biomarkers for evaluation of perinatal encephalopathy","volume":"7","author":"Graham","year":"2016","journal-title":"Front Pharmacol"},{"key":"2022022810501900400_sct312854-bib-0009","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/pr.2013.238","article-title":"Intermittent or sustained systemic inflammation and the preterm brain","volume":"75","author":"Dammann","year":"2014","journal-title":"Pediatr Res"},{"key":"2022022810501900400_sct312854-bib-0010","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/ana.22670","article-title":"Cell therapy for neonatal hypoxia-ischemia and cerebral palsy","volume":"71","author":"Bennet","year":"2012","journal-title":"Ann Neurol"},{"key":"2022022810501900400_sct312854-bib-0011","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fnins.2013.00194","article-title":"Stem cell therapy to protect and repair the developing brain: a review of mechanisms of action of cord blood and amnion epithelial derived cells","volume":"7","author":"Castillo-Melendez","year":"2013","journal-title":"Front Neurosci"},{"key":"2022022810501900400_sct312854-bib-0012","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5607\/en.2017.26.1.55","article-title":"Effect of single and double administration of human umbilical cord blood-derived mesenchymal stem cells following focal cerebral ischemia in rats","volume":"26","author":"Park","year":"2017","journal-title":"Exp Neurobiol"},{"key":"2022022810501900400_sct312854-bib-0013","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.jcyt.2014.06.004","article-title":"Cell-based therapies for the preterm infant","volume":"16","author":"Zhu","year":"2014","journal-title":"Cytotherapy"},{"key":"2022022810501900400_sct312854-bib-0014","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.clp.2015.04.008","article-title":"Stem cells: potential therapy for neonatal injury?","volume":"42","author":"Yoshimoto","year":"2015","journal-title":"Clin Perinatol"},{"key":"2022022810501900400_sct312854-bib-0015","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1542\/peds.2011-2576","article-title":"Cell therapy: a novel treatment approach for bronchopulmonary dysplasia","volume":"130","author":"Vosdoganes","year":"2012","journal-title":"Pediatrics"},{"key":"2022022810501900400_sct312854-bib-0016","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bpobgyn.2015.08.014","article-title":"Placental stem cells","volume":"13-29","author":"Antoniadou","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2022022810501900400_sct312854-bib-0017","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1161\/STROKEAHA.117.019136","article-title":"Acute or delayed systemic administration of human amnion epithelial cells improves outcomes in experimental stroke","volume":"49","author":"Evans","year":"2018","journal-title":"Stroke"},{"key":"2022022810501900400_sct312854-bib-0018","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-015-0322-8","article-title":"Immunosuppressive potential of human amnion epithelial cells in the treatment of experimental autoimmune encephalomyelitis","volume":"12","author":"Mcdonald","year":"2015","journal-title":"J Neuroinflammation"},{"key":"2022022810501900400_sct312854-bib-0019","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000346683","article-title":"Human amnion epithelial cells reduce fetal brain injury in response to intrauterine inflammation","volume":"35","author":"Yawno","year":"2013","journal-title":"Dev Neurosci"},{"key":"2022022810501900400_sct312854-bib-0020","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1159\/000371415","article-title":"Human amnion epithelial cells modulate ventilation-induced white matter pathology in preterm lambs","volume":"37","author":"Barton","year":"2015","journal-title":"Dev Neurosci"},{"key":"2022022810501900400_sct312854-bib-0021","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/709763","article-title":"Amnion epithelial cells as a candidate therapy for acute and chronic lung injury","volume":"2012","author":"Hodges","year":"2012","journal-title":"Stem Cells Int"},{"key":"2022022810501900400_sct312854-bib-0022","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jcyt.2013.03.004","article-title":"Human amnion epithelial cells modulate hyperoxia-induced neonatal lung injury in mice","volume":"15","author":"Vosdoganes","year":"2013","journal-title":"Cytotherapy"},{"key":"2022022810501900400_sct312854-bib-0023","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/0271678X17729954","article-title":"Delayed intranasal infusion of human amnion epithelial cells improves white matter maturation after asphyxia in preterm fetal sheep","volume":"39","author":"Van Den Heuij","year":"2019","journal-title":"J Cereb Blood Flow Metab"},{"key":"2022022810501900400_sct312854-bib-0024","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.expneurol.2016.06.017","article-title":"Preterm white matter brain injury is prevented by early administration of umbilical cord blood cells","volume":"283","author":"Li","year":"2016","journal-title":"Exp Neurol"},{"key":"2022022810501900400_sct312854-bib-0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1113\/jphysiol.2006.105197","article-title":"Relationship between evolving epileptiform activity and delayed loss of mitochondrial activity after asphyxia measured by near-infrared spectroscopy in preterm fetal sheep","volume":"572","author":"Bennet","year":"2006","journal-title":"J Physiol"},{"key":"2022022810501900400_sct312854-bib-0026","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2990.1979.tb00664.x","article-title":"Foetal brain development in the sheep","volume":"5","author":"Mcintosh","year":"1979","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2022022810501900400_sct312854-bib-0027","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/sj.jcbfm.9600087","article-title":"Cerebral oxygenation during post-asphyxial seizures in near-term fetal sheep","volume":"25","author":"Gonzalez","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"2022022810501900400_sct312854-bib-0028","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1113\/jphysiol.2014.281253","article-title":"The effects of dexamethasone on post-asphyxial cerebral oxygenation in the preterm fetal sheep","volume":"592","author":"Lear","year":"2014","journal-title":"J Physiol"},{"key":"2022022810501900400_sct312854-bib-0029","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0165-0270(90)90066-O","article-title":"Real-time spectral intensity analysis of the eeg on a common microcomputer","volume":"32","author":"Williams","year":"1990","journal-title":"J Neurosci Methods"},{"key":"2022022810501900400_sct312854-bib-0030","doi-asserted-by":"crossref","first-page":"1E.6.1","DOI":"10.1002\/9780470151808.sc01e06s13","article-title":"Amnion epithelial cell isolation and characterization for clinical use","volume":"13","author":"Murphy","year":"2010","journal-title":"Curr Protoc Stem Cell Biol"},{"key":"2022022810501900400_sct312854-bib-0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096558","article-title":"Connexin hemichannel blockade is neuroprotective after asphyxia in preterm fetal sheep","volume":"9","author":"Davidson","year":"2014","journal-title":"PLoS One"},{"key":"2022022810501900400_sct312854-bib-0032","doi-asserted-by":"crossref","first-page":"R189","DOI":"10.1152\/ajpregu.00388.2012","article-title":"Acute on chronic exposure to endotoxin in preterm fetal sheep","volume":"304","author":"Mathai","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2022022810501900400_sct312854-bib-0033","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12974-020-01769-6","article-title":"Tumor necrosis factor inhibition attenuates white matter gliosis after systemic inflammation in preterm fetal sheep","volume":"17","author":"Galinsky","year":"2020","journal-title":"J Neuroinflammation"},{"key":"2022022810501900400_sct312854-bib-0034","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.22654","article-title":"Connexin hemichannel blockade improves outcomes in a model of fetal ischemia","volume":"71","author":"Davidson","year":"2012","journal-title":"Ann Neurol"},{"key":"2022022810501900400_sct312854-bib-0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jri.2017.11.003","article-title":"Chronic inflammation and impaired development of the preterm brain","volume":"125","author":"Bennet","year":"2018","journal-title":"J Reprod Immunol"},{"key":"2022022810501900400_sct312854-bib-0036","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1203\/01.PDR.0000148286.53572.95","article-title":"The relationship of csf and plasma cytokine levels to cerebral white matter injury in the premature newborn","volume":"57","author":"Ellison","year":"2005","journal-title":"Pediatr Res"},{"key":"2022022810501900400_sct312854-bib-0037","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/pr.2013.238","article-title":"Intermittent or sustained systemic inflammation and the preterm brain","volume":"75","author":"Dammann","year":"2014","journal-title":"Pediatr Res"},{"key":"2022022810501900400_sct312854-bib-0038","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1097\/01.TP.0000144606.84234.49","article-title":"Engraftment potential of human amnion and chorion cells derived from term placenta","volume":"78","author":"Bailo","year":"2004","journal-title":"Transplantation"},{"key":"2022022810501900400_sct312854-bib-0039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146082","article-title":"Markers of pluripotency in human amniotic epithelial cells and their differentiation to progenitor of cortical neurons","volume":"10","author":"Garcia-Castro","year":"2015","journal-title":"PLoS One"},{"key":"2022022810501900400_sct312854-bib-0040","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1254\/jjp.85.20","article-title":"Non-neuronal neurotransmitters and neurotrophic factors in amniotic epithelial cells: expression and function in humans and monkey","volume":"85","author":"Sakuragawa","year":"2001","journal-title":"Jpn J Pharmacol"},{"key":"2022022810501900400_sct312854-bib-0041","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088319","article-title":"Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells","volume":"9","author":"Yamahara","year":"2014","journal-title":"PLoS One"},{"key":"2022022810501900400_sct312854-bib-0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/561494","article-title":"The role of cytokines and inflammatory cells in perinatal brain injury","volume":"2012","author":"Mcadams","year":"2012","journal-title":"Neurol Res Int"},{"key":"2022022810501900400_sct312854-bib-0043","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/scrt542","article-title":"Amnion cell-mediated immune modulation following bleomycin challenge: controlling the regulatory t cell response","volume":"6","author":"Tan","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"2022022810501900400_sct312854-bib-0044","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3727\/096368912X661409","article-title":"Human amnion epithelial cells mediate lung repair by directly modulating macrophage recruitment and polarization","volume":"23","author":"Tan","year":"2014","journal-title":"Cell Transplant"},{"key":"2022022810501900400_sct312854-bib-0045","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.expneurol.2018.07.006","article-title":"Preterm umbilical cord blood derived mesenchymal stem\/stromal cells protect preterm white matter brain development against hypoxia-ischemia","volume":"308","author":"Li","year":"2018","journal-title":"Exp Neurol"},{"key":"2022022810501900400_sct312854-bib-0046","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1113\/JP274928","article-title":"A working model for hypothermic neuroprotection","volume":"596","author":"Wassink","year":"2018","journal-title":"J Physiol"},{"key":"2022022810501900400_sct312854-bib-0047","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1113\/jphysiol.2006.119602","article-title":"The effect of cerebral hypothermia on white and grey matter injury induced by severe hypoxia in preterm fetal sheep","volume":"578","author":"Bennet","year":"2007","journal-title":"J Physiol"},{"key":"2022022810501900400_sct312854-bib-0048","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1161\/STROKEAHA.114.008484","article-title":"Hypothermic neuroprotection is associated with recovery of spectral edge frequency after asphyxia in preterm fetal sheep","volume":"46","author":"Wassink","year":"2015","journal-title":"Stroke"},{"key":"2022022810501900400_sct312854-bib-0049","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3389\/fphar.2019.01247","article-title":"Minocycline ameliorates depressive-like behavior and demyelination induced by transient global cerebral ischemia by inhibiting microglial activation","volume":"10","author":"Du","year":"2019","journal-title":"Front Pharmacol"},{"key":"2022022810501900400_sct312854-bib-0050","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1523\/JNEUROSCI.20-21-07994.2000","article-title":"Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat","volume":"20","author":"Nakajima","year":"2000","journal-title":"J Neurosci"},{"key":"2022022810501900400_sct312854-bib-0051","article-title":"Differential migration of mesenchymal stem cells to ischemic regions after middle cerebral artery occlusion in rats","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS One"},{"key":"2022022810501900400_sct312854-bib-0052","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.expneurol.2014.06.009","article-title":"Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury","volume":"261","author":"Donega","year":"2014","journal-title":"Exp Neurol"},{"key":"2022022810501900400_sct312854-bib-0053","doi-asserted-by":"crossref","first-page":"754","DOI":"10.5966\/sctm.2015-0197","article-title":"Mesenchymal stromal cell-derived extracellular vesicles protect the fetal brain after hypoxia-ischemia","volume":"5","author":"Ophelders","year":"2016","journal-title":"Stem Cells Translational Medicine"},{"key":"2022022810501900400_sct312854-bib-0054","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-015-0459-5","article-title":"Multipotent adult progenitor cells for hypoxic-ischemic injury in the preterm brain","volume":"12","author":"Jellema","year":"2015","journal-title":"J Neuroinflammation"},{"key":"2022022810501900400_sct312854-bib-0055","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.yebeh.2010.06.035","article-title":"Functional, metabolic, and synaptic changes after seizures as potential targets for antiepileptic therapy","volume":"19","author":"Loscher","year":"2010","journal-title":"Epilepsy Behav"},{"key":"2022022810501900400_sct312854-bib-0056","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.tips.2016.03.001","article-title":"Anti-inflammatory small molecules to treat seizures and epilepsy: from bench to bedside","volume":"37","author":"Dey","year":"2016","journal-title":"Trends Pharmacol Sci"},{"key":"2022022810501900400_sct312854-bib-0057","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fncel.2013.00157","article-title":"The role of dopamine signaling in epileptogenesis","volume":"7","author":"Bozzi","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"2022022810501900400_sct312854-bib-0058","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ymgme.2013.02.011","article-title":"Improved amino acid, bioenergetic metabolite and neurotransmitter profiles following human amnion epithelial cell transplant in intermediate maple syrup urine disease mice","volume":"109","author":"Skvorak","year":"2013","journal-title":"Mol Genet Metab"},{"key":"2022022810501900400_sct312854-bib-0059","doi-asserted-by":"crossref","first-page":"R1280","DOI":"10.1152\/ajpregu.00342.2007","article-title":"Male disadvantage? Fetal sex and cardiovascular responses to asphyxia in preterm fetal sheep","volume":"293","author":"Bennet","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2022022810501900400_sct312854-bib-0060","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1469-7793.1999.0247z.x","article-title":"The cardiovascular and cerebrovascular responses of the immature fetal sheep to acute umbilical cord occlusion","volume":"517","author":"Bennet","year":"1999","journal-title":"J Physiol"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sctm.20-0314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/sctm.20-0314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/10\/3\/427\/42626317\/stcltm_10_3_427.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/10\/3\/427\/42626317\/stcltm_10_3_427.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T10:59:21Z","timestamp":1646045961000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/10\/3\/427\/6404049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,26]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,10,26]]},"published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/sctm.20-0314","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,1]]},"published":{"date-parts":[[2020,10,26]]},"assertion":[{"value":"2020-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}