{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T02:43:00Z","timestamp":1774320180013,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":356,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771971"],"award-info":[{"award-number":["81771971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18ZR1407000"],"award-info":[{"award-number":["18ZR1407000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20ZR1411700"],"award-info":[{"award-number":["20ZR1411700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Talent Program Foundation for the Excellent Backbone of Zhongshan Hospital","award":["2019ZSGG07"],"award-info":[{"award-number":["2019ZSGG07"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771971"],"award-info":[{"award-number":["81771971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18ZR1407000"],"award-info":[{"award-number":["18ZR1407000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20ZR1411700"],"award-info":[{"award-number":["20ZR1411700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Induced pluripotent stem cells (iPSCs) offer an effective platform for studies of human physiology and have revealed new possibilities for disease modeling at the cellular level. These cells also have the potential to be leveraged in the practice of precision medicine, including personalized drug testing. Aortic diseases result in significant morbidity and mortality and pose a global burden to healthcare. Their pathogenesis is mostly associated with functional alterations of vascular components, such as endothelial cells and vascular smooth muscle cells. Drugs that have been proven to be effective in animal models often fail to protect patients from adverse aortic events in clinical studies, provoking researchers to develop reliable in vitro models using human cells. In this review, we summarize the patient iPSC-derived aortic cells that have been utilized to model aortic diseases in vitro. In advanced models, hemodynamic factors, such as blood flow-induced shear stress and cyclic strain, have been added to the systems to replicate cellular microenvironments in the aortic wall. Examples of the utility of such factors in modeling various aortopathies, such as Marfan syndrome, Loeys-Dietz syndrome, and bicuspid aortic valve-related aortopathy, are also described. Overall, the iPSC-based in vitro cell models have shown the potential to promote the development and practice of precision medicine in the treatment of aortic diseases.<\/jats:p>","DOI":"10.1002\/sctm.20-0322","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T08:19:23Z","timestamp":1605169163000},"page":"190-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Modeling aortic diseases using induced pluripotent stem cells"],"prefix":"10.1093","volume":"10","author":[{"given":"Kai","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Zhongshan Hospital Fudan University, Shanghai, People's Republic of China"},{"name":"Shanghai Institute of Cardiovascular Diseases, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenrui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Zhongshan Hospital Fudan University, Shanghai, People's Republic of China"},{"name":"Shanghai Institute of Cardiovascular Diseases, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Zhongshan Hospital Fudan University, Shanghai, People's Republic of China"},{"name":"Shanghai Institute of Cardiovascular Diseases, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Shrike","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Cambridge, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Zhongshan Hospital Fudan University, Shanghai, People's Republic of China"},{"name":"Shanghai Institute of Cardiovascular Diseases, Shanghai, People's Republic of China"},{"name":"Institutes of Biomedical Sciences and Department of Systems Biology for Medicine, Shanghai Medical College Fudan University, Shanghai, People's Republic of China"},{"name":"The State Key Laboratory of Molecular Engineering of Polymers Fudan University, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Zhongshan Hospital Fudan University, Shanghai, People's Republic of China"},{"name":"Shanghai Institute of Cardiovascular Diseases, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Zhongshan Hospital Fudan University, Shanghai, People's Republic of China"},{"name":"Shanghai Institute of Cardiovascular Diseases, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"issue":"4","key":"2022022810502519400_sct312861-bib-0001","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrcardio.2016.211","article-title":"Aetiology and management of hereditary aortopathy","volume":"14","author":"Verstraeten","year":"2017","journal-title":"Nat Rev Cardiol"},{"issue":"2","key":"2022022810502519400_sct312861-bib-0002","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/ATVBAHA.118.310956","article-title":"Therapies for thoracic aortic aneurysms and acute aortic dissections","volume":"39","author":"Milewicz","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"2022022810502519400_sct312861-bib-0003","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/HCO.0000000000000667","article-title":"Type A aortic dissection complicated by malperfusion syndrome","volume":"34","author":"Norton","year":"2019","journal-title":"Curr Opin Cardiol"},{"issue":"11","key":"2022022810502519400_sct312861-bib-0004","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.jacc.2019.07.063","article-title":"Optimal treatment of uncomplicated type B aortic dissection: JACC review topic of the week","volume":"74","author":"Tadros","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"2022022810502519400_sct312861-bib-0005","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1161\/CIRCRESAHA.118.312439","article-title":"Pharmacologic management of aneurysms","volume":"124","author":"Lindeman","year":"2019","journal-title":"Circ Res"},{"issue":"18","key":"2022022810502519400_sct312861-bib-0006","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.jacc.2016.01.083","article-title":"Translation of human-induced pluripotent stem cells: from clinical trial in a dish to precision medicine","volume":"67","author":"Sayed","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2022022810502519400_sct312861-bib-0007","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.addr.2015.09.011","article-title":"In vitro cardiac tissue models: current status and future prospects","volume":"96","author":"Mathur","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"2022022810502519400_sct312861-bib-0008","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1124\/pr.116.013003","article-title":"Patient and disease-specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics","volume":"72","author":"Paik","year":"2020","journal-title":"Pharmacol Rev"},{"key":"2022022810502519400_sct312861-bib-0009","volume-title":"Medical gallery of Blausen medical 2014","author":"Blausen.com"},{"issue":"2","key":"2022022810502519400_sct312861-bib-0010","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1172\/JCI123547","article-title":"Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome","volume":"129","author":"MacFarlane","year":"2019","journal-title":"J Clin Invest"},{"issue":"14","key":"2022022810502519400_sct312861-bib-0011","first-page":"2415","article-title":"The role of mechanical stimuli in the vascular differentiation of mesenchymal stem cells","volume":"128","author":"Dan","year":"2015","journal-title":"J Cell Sci"},{"issue":"8","key":"2022022810502519400_sct312861-bib-0012","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/sctm.17-0004","article-title":"Exposure of induced pluripotent stem cell-derived vascular endothelial and smooth muscle cells in coculture to hemodynamics induces primary vascular cell-like phenotypes","volume":"6","author":"Collado","year":"2017","journal-title":"Stem Cells Translational Medicine"},{"issue":"11","key":"2022022810502519400_sct312861-bib-0013","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1039\/C8LC00286J","article-title":"A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions","volume":"18","author":"Engeland","year":"2018","journal-title":"Lab Chip"},{"issue":"1","key":"2022022810502519400_sct312861-bib-0014","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s10544-019-0460-3","article-title":"Bioprinting a 3D vascular construct for engineering a vessel-on-a-chip","volume":"22","author":"Abudupataer","year":"2019","journal-title":"Biomed Microdevices"},{"key":"2022022810502519400_sct312861-bib-0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2019.08.017","article-title":"Biomechanics of aortic wall failure with a focus on dissection and aneurysm: a review","volume":"99","author":"Sherifova","year":"2019","journal-title":"Acta Biomater"},{"issue":"83","key":"2022022810502519400_sct312861-bib-0016","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2012.1004","article-title":"Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review","volume":"10","author":"Tsamis","year":"2013","journal-title":"J R Soc Interface"},{"issue":"7","key":"2022022810502519400_sct312861-bib-0017","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1161\/ATVBAHA.119.312787","article-title":"Role of vascular smooth muscle cell phenotypic switching and calcification in aortic aneurysm formation","volume":"39","author":"Petsophonsakul","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"2022022810502519400_sct312861-bib-0018","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1172\/JCI69942","article-title":"Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis","volume":"124","author":"Li","year":"2014","journal-title":"J Clin Invest"},{"key":"2022022810502519400_sct312861-bib-0019","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3389\/fphys.2017.00687","article-title":"Pathogenic mechanisms of bicuspid aortic valve aortopathy","volume":"8","author":"Yassine","year":"2017","journal-title":"Front Physiol"},{"issue":"7","key":"2022022810502519400_sct312861-bib-0020","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1161\/ATVBAHA.119.312265","article-title":"Generation of endothelial cells from human pluripotent stem cells","volume":"39","author":"Williams","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"2022022810502519400_sct312861-bib-0021","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/cr.2014.59","article-title":"Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells","volume":"24","author":"Sahara","year":"2014","journal-title":"Cell Res"},{"key":"2022022810502519400_sct312861-bib-0022","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4998","article-title":"A Snail1\/Notch1 signalling axis controls embryonic vascular development","volume":"5","author":"Wu","year":"2014","journal-title":"Nat Commun"},{"key":"2022022810502519400_sct312861-bib-0023","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.biomaterials.2015.02.121","article-title":"Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor","volume":"53","author":"Sivarapatna","year":"2015","journal-title":"Biomaterials"},{"issue":"11","key":"2022022810502519400_sct312861-bib-0024","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1161\/ATVBAHA.117.309196","article-title":"Differentiation and application of induced pluripotent stem cell-derived vascular smooth muscle cells","volume":"37","author":"Maguire","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2022022810502519400_sct312861-bib-0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.actbio.2017.01.083","article-title":"Enhanced elastin synthesis and maturation in human vascular smooth muscle tissue derived from induced-pluripotent stem cells","volume":"52","author":"Eoh","year":"2017","journal-title":"Acta Biomater"},{"issue":"7","key":"2022022810502519400_sct312861-bib-0026","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1182\/blood-2002-08-2560","article-title":"Shear stress inhibits adhesion molecule expression in vascular endothelial cells induced by coculture with smooth muscle cells","volume":"101","author":"Chiu","year":"2003","journal-title":"Blood"},{"issue":"2","key":"2022022810502519400_sct312861-bib-0027","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/CIRCRESAHA.118.313374","article-title":"Smooth muscle contact drives endothelial regeneration by BMPR2-Notch1-mediated metabolic and epigenetic changes","volume":"124","author":"Miyagawa","year":"2019","journal-title":"Circ Res"},{"issue":"3","key":"2022022810502519400_sct312861-bib-0028","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000091102","article-title":"The effect of phenotype on mechanical stretch-induced vascular smooth muscle cell apoptosis","volume":"43","author":"Su","year":"2006","journal-title":"J Vasc Res"},{"issue":"10","key":"2022022810502519400_sct312861-bib-0029","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1161\/ATVBAHA.114.303422","article-title":"Shear stress-initiated signaling and its regulation of endothelial function","volume":"34","author":"Zhou","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"2022022810502519400_sct312861-bib-0030","doi-asserted-by":"crossref","first-page":"1800109","DOI":"10.1002\/adbi.201800109","article-title":"Mimicking human pathophysiology in organ-on-chip devices","volume":"2","author":"Yesil-Celiktas","year":"2018","journal-title":"Adv Biosyst"},{"issue":"15","key":"2022022810502519400_sct312861-bib-0031","doi-asserted-by":"crossref","first-page":"1603737","DOI":"10.1002\/smll.201603737","article-title":"Biomechanical strain exacerbates inflammation on a progeria-on-a-chip model","volume":"13","author":"Ribas","year":"2017","journal-title":"Small"},{"issue":"4","key":"2022022810502519400_sct312861-bib-0032","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1161\/CIRCRESAHA.118.313186","article-title":"Open and endovascular management of aortic aneurysms","volume":"124","author":"Swerdlow","year":"2019","journal-title":"Circ Res"},{"key":"2022022810502519400_sct312861-bib-0033","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.scr.2017.06.016","article-title":"A Marfan syndrome human induced pluripotent stem cell line with a heterozygous FBN1 c.4082G&gt;A mutation, ISMMSi002-B, for disease modeling","volume":"23","author":"Klein","year":"2017","journal-title":"Stem Cell Res"},{"issue":"5","key":"2022022810502519400_sct312861-bib-0034","doi-asserted-by":"crossref","first-page":"588","DOI":"10.7150\/ijbs.19517","article-title":"Recapitulating and correcting Marfan syndrome in a cellular model","volume":"13","author":"Park","year":"2017","journal-title":"Int J Biol Sci"},{"issue":"12","key":"2022022810502519400_sct312861-bib-0035","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1002\/stem.1250","article-title":"Exogenous activation of BMP-2 signaling overcomes TGFbeta-mediated inhibition of osteogenesis in Marfan embryonic stem cells and Marfan patient-specific induced pluripotent stem cells","volume":"30","author":"Quarto","year":"2012","journal-title":"Stem Cells"},{"issue":"1","key":"2022022810502519400_sct312861-bib-0036","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng.3723","article-title":"An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death","volume":"49","author":"Granata","year":"2017","journal-title":"Nat Genet"},{"issue":"4","key":"2022022810502519400_sct312861-bib-0037","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jtcvs.2015.12.001","article-title":"Surgery for aortic dilatation in patients with bicuspid aortic valves: a statement of clarification from the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"151","author":"2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease Representative Members","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"6","key":"2022022810502519400_sct312861-bib-0038","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/HCO.0000000000000328","article-title":"Genetics of bicuspid aortic valve aortopathy","volume":"31","author":"Andreassi","year":"2016","journal-title":"Curr Opin Cardiol"},{"issue":"2","key":"2022022810502519400_sct312861-bib-0039","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jtcvs.2018.02.087","article-title":"Induced pluripotent stem cells with NOTCH1 gene mutation show impaired differentiation into smooth muscle and endothelial cells: implications for bicuspid aortic valve-related aortopathy","volume":"156","author":"Jiao","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"21","key":"2022022810502519400_sct312861-bib-0040","doi-asserted-by":"crossref","first-page":"e91353","DOI":"10.1172\/jci.insight.91353","article-title":"Notch1 haploinsufficiency causes ascending aortic aneurysms in mice","volume":"2","author":"Koenig","year":"2017","journal-title":"JCI Insight"},{"key":"2022022810502519400_sct312861-bib-0041","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ebiom.2016.06.045","article-title":"Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves","volume":"10","author":"Jiao","year":"2016","journal-title":"EBioMedicine"},{"key":"2022022810502519400_sct312861-bib-0042","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.scr.2017.03.012","article-title":"Generation of an induced pluripotent stem cell line from a Loeys-Dietz syndrome patient with transforming growth factor-beta receptor-2 gene mutation","volume":"20","author":"Hu","year":"2017","journal-title":"Stem Cell Res"},{"key":"2022022810502519400_sct312861-bib-0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2020.101707","article-title":"Generation of three induced pluripotent stem cell lines (MHHi012-A, MHHi013-A, MHHi014-A) from a family with Loeys-Dietz syndrome carrying a heterozygous p.M253I (c.759G&gt;A) mutation in the TGFBR1 gene","volume":"43","author":"Pongpamorn","year":"2020","journal-title":"Stem Cell Res"},{"issue":"14","key":"2022022810502519400_sct312861-bib-0044","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1161\/CIRCULATIONAHA.112.116996","article-title":"Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells","volume":"126","author":"Ge","year":"2012","journal-title":"Circulation"},{"issue":"1","key":"2022022810502519400_sct312861-bib-0045","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5966\/sctm.2012-0054","article-title":"Modeling and rescue of the vascular phenotype of Williams-Beuren syndrome in patient induced pluripotent stem cells","volume":"2","author":"Kinnear","year":"2013","journal-title":"Stem Cells Translational Medicine"},{"issue":"7","key":"2022022810502519400_sct312861-bib-0046","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41576-019-0100-z","article-title":"Induced pluripotent stem cells in disease modelling and drug discovery","volume":"20","author":"Rowe","year":"2019","journal-title":"Nat Rev Genet"},{"key":"2022022810502519400_sct312861-bib-0047","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.biomaterials.2016.06.010","article-title":"Implantable tissue-engineered blood vessels from human induced pluripotent stem cells","volume":"102","author":"Gui","year":"2016","journal-title":"Biomaterials"},{"issue":"31","key":"2022022810502519400_sct312861-bib-0048","article-title":"A tumor-on-a-chip system with bioprinted blood and lymphatic vessel pair","volume":"29","author":"Cao","year":"2019","journal-title":"Adv Funct Mater"},{"issue":"1","key":"2022022810502519400_sct312861-bib-0049","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-14997-4","article-title":"Complexation-induced resolution enhancement of 3D-printed hydrogel constructs","volume":"11","author":"Gong","year":"2020","journal-title":"Nat Commun"},{"key":"2022022810502519400_sct312861-bib-0050","article-title":"Investigating lymphangiogenesis in a sacrificially bioprinted volumetric model of breast tumor tissue","author":"Liu","year":"2020","journal-title":"Methods"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sctm.20-0322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/sctm.20-0322","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/10\/2\/190\/42626516\/stcltm_10_2_190.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/10\/2\/190\/42626516\/stcltm_10_2_190.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T11:01:07Z","timestamp":1646046067000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/10\/2\/190\/6404023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,12]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,11,12]]},"published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/sctm.20-0322","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2,1]]},"published":{"date-parts":[[2020,11,12]]},"assertion":[{"value":"2020-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}