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To explore cell replacement therapies as a possible approach to treat FRDA, we examined transplantation of sensory neural progenitors derived from human embryonic stem cells (hESC) and FRDA induced pluripotent stem cells (iPSC) into adult rodent DRG regions. Our data showed survival and differentiation of hESC and FRDA iPSC-derived progenitors in the DRG 2 and 8\u2009weeks post-transplantation, respectively. Donor cells expressed neuronal markers, including sensory and glial markers, demonstrating differentiation to these lineages. These results are novel and a highly significant first step in showing the possibility of using stem cells as a cell replacement therapy to treat DRG neurodegeneration in FRDA as well as other peripheral neuropathies.<\/jats:p>","DOI":"10.1002\/sctm.20-0334","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T09:35:50Z","timestamp":1616060150000},"page":"1157-1169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["In Vivo Survival and Differentiation of Friedreich Ataxia iPSC-Derived Sensory Neurons Transplanted in the Adult Dorsal Root Ganglia"],"prefix":"10.1093","volume":"10","author":[{"given":"Serena","family":"Viventi","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering \u00a0The University of Melbourne, Parkville, Australia"},{"name":"The Florey Institute of Neuroscience and Mental Health, Parkville, 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