{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:54:56Z","timestamp":1786978496960,"version":"build-2736575974"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"vor","delay-in-days":239,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Preclinical and early phase clinical studies suggest that an appropriately dosed umbilical cord blood (CB) infusion has the potential to help improve motor function in young children with cerebral palsy (CP). As many children with CP do not have their own CB available, use of allogeneic cells would extend access to this potentially beneficial therapy to more children. In this phase I, open-label study, 15 children, aged 1 to 6\u2009years, with moderate to severe spastic CP were treated with a single intravenous infusion of allogeneic human leukocyte antigen (HLA) matched or partially matched sibling CB with a cell dose of \u22652.5 \u00d7\u2009107 cells\/kg based on the pre-cryopreservation count (median infused cell dose, 3.3 \u00d7\u2009107; range, 1.8-5.2 \u00d7\u2009107). There were a total of 49 adverse events (AEs) over a 2-year time period, but there were no AEs related to the CB infusions. Specifically, there were no acute infusion reactions and no antibody formation against platelets, red blood cells, or donor-specific HLA antigens. Donor cells were not detected in peripheral blood 6 months later. Six months after infusion, participants were assessed for response and experienced a mean\u2009\u00b1\u2009SD increase of 4.7 \u00b1\u20092.5 points on the Gross Motor Function Measure-66 and 1 \u00b1\u20092.9 points on the Peabody Gross Motor Quotient. Appropriately dosed, allogeneic partially or fully HLA-matched sibling CB infusion is well tolerated and potentially beneficial in young children with CP.<\/jats:p>","DOI":"10.1002\/sctm.20-0470","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T05:21:49Z","timestamp":1622784109000},"page":"1258-1265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sibling Umbilical Cord Blood Infusion is Safe in Young Children with Cerebral Palsy"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8085-1013","authenticated-orcid":false,"given":"Jessica M.","family":"Sun","sequence":"first","affiliation":[{"name":"Marcus Center for Cellular Cures \u00a0Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Case","sequence":"additional","affiliation":[{"name":"Department of Physical and Occupational Therapy \u00a0Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad A.","family":"Mikati","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology \u00a0Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Jasien","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology \u00a0Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Marcus Center for Cellular Cures \u00a0Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Waters-Pick","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Laboratory \u00a0Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Worley","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology \u00a0Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5410-8146","authenticated-orcid":false,"given":"Jesse","family":"Troy","sequence":"additional","affiliation":[{"name":"Marcus Center for Cellular Cures \u00a0Duke University Medical Center, Durham, North Carolina, USA"},{"name":"Department of Biostatistics and Bioinformatics \u00a0Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Kurtzberg","sequence":"additional","affiliation":[{"name":"Marcus Center for Cellular Cures \u00a0Duke University Medical Center, Durham, North Carolina, 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