{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:41:51Z","timestamp":1792633311762,"version":"4.5.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":351,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008453","name":"Ontario Institute for Regenerative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cell-based therapies hold promise to substantially curb complications from extreme preterm birth, the main cause of death in children below the age of 5\u2009years. Exciting preclinical studies in experimental neonatal lung injury have provided the impetus for the initiation of early phase clinical trials in extreme preterm infants at risk of developing bronchopulmonary dysplasia. Clinical translation of promising therapies, however, is slow and often fails. In the adult population, results of clinical trials so far have not matched the enticing preclinical data. The neonatal field has experienced many hard-earned lessons with the implementation of oxygen therapy or postnatal steroids. Here we briefly summarize the preclinical data that have permitted the initiation of early phase clinical trials of cell-based therapies in extreme preterm infants and describe the INCuBAToR concept (Innovative Neonatal Cellular Therapy for Bronchopulmonary Dysplasia: Accelerating Translation of Research), an evidence-based approach to mitigate the risk of translating advanced therapies into this vulnerable patient population. The INCuBAToR addresses several of the shortcomings at the preclinical and the clinical stage that usually contribute to the failure of clinical translation through (a) systematic reviews of preclinical and clinical studies, (b) integrated knowledge transfer through engaging important stakeholders early on, (c) early economic evaluation to determine if a novel therapy is viable, and (d) retrospective and prospective studies to define and test ideal eligibility criteria to optimize clinical trial design. The INCuBAToR concept can be applied to any novel therapy in order to enhance the likelihood of success of clinical translation in a timely, transparent, rigorous, and evidence-based fashion.<\/jats:p>","DOI":"10.1002\/sctm.20-0508","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T02:22:52Z","timestamp":1613269372000},"page":"968-975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Benefits and obstacles to cell therapy in neonates: The INCuBAToR (Innovative Neonatal Cellular Therapy for Bronchopulmonary Dysplasia: Accelerating Translation of Research)"],"prefix":"10.1093","volume":"10","author":[{"given":"Bernard","family":"Th\u00e9baud","sequence":"first","affiliation":[{"name":"Regenerative Medicine Program \u00a0The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada"},{"name":"Neonatology, Department of Pediatrics \u00a0Children's Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, Ottawa, Ontario, Canada"},{"name":"Department of Cellular and Molecular Medicine \u00a0University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Lalu","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program \u00a0The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada"},{"name":"Department of Cellular and Molecular Medicine \u00a0University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Department of Anesthesiology and Pain Medicine \u00a0University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Clinical Epidemiology Program \u00a0The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Renesme","sequence":"additional","affiliation":[{"name":"Neonatology, Department of Pediatrics \u00a0Children's Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Katwyk","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program \u00a0The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Presseau","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program \u00a0The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada"},{"name":"School of Public Health and Preventive Medicine \u00a0University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kednapa","family":"Thavorn","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program \u00a0The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada"},{"name":"School of Public Health and Preventive Medicine \u00a0University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly D.","family":"Cobey","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program \u00a0The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada"},{"name":"Centre for Journalology \u00a0The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hutton","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program \u00a0The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Moher","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program \u00a0The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger F.","family":"Soll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Larner College of Medicine \u00a0University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Fergusson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program \u00a0The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"2022022810533148400_sct312900-bib-0001","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1056\/NEJMra067279","article-title":"Chronic lung disease after premature birth","volume":"357","author":"Baraldi","year":"2007","journal-title":"N Engl J Med"},{"key":"2022022810533148400_sct312900-bib-0002","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-019-0127-7","article-title":"Bronchopulmonary 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