{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:22:35Z","timestamp":1769844155827,"version":"3.49.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":189,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001724","name":"The Kosciuszko Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001724","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001568","name":"University of Illinois Chancellor's Innovation Fund (CIF) Proof of Concept Award","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001568","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001568","name":"Cricket Island Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001568","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Duchenne muscular dystrophy (DMD) is a progressive and lethal disease, caused by X-linked mutations of the dystrophin encoding gene. The lack of dystrophin leads to muscle weakness, degeneration, fibrosis, and progressive loss of skeletal, cardiac, and respiratory muscle function resulting in premature death due to the cardiac and respiratory failure. There is no cure for DMD and current therapies neither cure nor arrest disease progression. Thus, there is an urgent need to develop new approaches and safer therapies for DMD patients. We have previously reported functional improvements which correlated with increased dystrophin expression following transplantation of dystrophin expressing chimeric (DEC) cells of myoblast origin to the mdx mouse models of DMD. In this study, we demonstrated that systemic-intraosseous transplantation of DEC human cells derived from myoblasts of normal and DMD-affected donors, increased dystrophin expression in cardiac, respiratory, and skeletal muscles of the mdx\/scid mouse model of DMD. DEC transplant correlated with preservation of ejection fraction and fractional shortening on echocardiography, improved respiratory function on plethysmography, and improved strength and function of the limb skeletal muscles. Enhanced function was associated with improved muscle histopathology, revealing reduced mdx pathology, fibrosis, decreased inflammation, and preserved muscle morphology and architecture. Our findings confirm that DECs generate a systemic protective effect in DMD-affected target organs. Therefore, DECs represents a novel therapeutic approach with the potential to preserve or enhance multiorgan function of the skeletal, cardiac, and respiratory muscles critical for the well-being of DMD patients.<\/jats:p>","DOI":"10.1002\/sctm.21-0054","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T10:04:37Z","timestamp":1626948277000},"page":"1406-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Human Dystrophin Expressing Chimeric (DEC) Cell Therapy Ameliorates Cardiac, Respiratory, and Skeletal Muscle's Function in Duchenne Muscular Dystrophy"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-6122","authenticated-orcid":false,"given":"Maria","family":"Siemionow","sequence":"first","affiliation":[{"name":"Department of Orthopaedics \u00a0University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Langa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics \u00a0University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Harasymczuk","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics \u00a0University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Cwykiel","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics \u00a0University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6309-8672","authenticated-orcid":false,"given":"Magdalena","family":"Sielewicz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics \u00a0University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslaw","family":"Smieszek","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics \u00a0University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahlke","family":"Heydemann","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics \u00a0University of Illinois at Chicago, Chicago, Illinois, USA"},{"name":"Center for Cardiovascular Research \u00a0University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"issue":"6","key":"2022022811012128800_sct312990-bib-0001","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.ejpn.2016.07.020","article-title":"Why are some patients with Duchenne muscular dystrophy dying young: an analysis of causes of death in 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