{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:23:51Z","timestamp":1784132631810,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,2,19]],"date-time":"2002-02-19T00:00:00Z","timestamp":1014076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Statistics in Medicine"],"published-print":{"date-parts":[[2002,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Statistical methods for testing and interval estimation of the ratio of marginal probabilities in the matched\u2010pair setting are considered in this paper. We are especially interested in the situation where the null value is not one, as in one\u2010sided equivalence trials. We propose a Fieller\u2010type statistic based on constrained maximum likelihood (CML) estimation of nuisance parameters. For a series of examples, the significance level of the CML test is satisfactorily close to the nominal level, while a Wald\u2010type test is anticonservative for reasonable sample sizes. We present formulae for approximate power and sample size for the CML and Wald tests. The matched design is seen to have a clear advantage over the unmatched design in terms of asymptotic efficiency when the two responses of the pair are highly positively correlated. We recommend the CML method over the Wald method, especially for small or moderate sample sizes. Published in 2002 by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/sim.1017","type":"journal-article","created":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T01:26:51Z","timestamp":1031707611000},"page":"689-699","source":"Crossref","is-referenced-by-count":49,"title":["Analysis of the ratio of marginal probabilities in a matched\u2010pair setting"],"prefix":"10.1002","volume":"21","author":[{"given":"Jun\u2010mo","family":"Nam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Blackwelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,2,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1367","volume-title":"Encyclopedia of Biostatistics","author":"Blackwelder WC","year":"1998"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780141611"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.2307\/2533508"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<891::AID-SIM780>3.0.CO;2-B"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19991230)18:24<3511::AID-SIM303>3.0.CO;2-A"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19981015)17:19<2207::AID-SIM920>3.0.CO;2-Y"},{"key":"e_1_2_1_8_2","volume-title":"Proceedings of the Biometrics Section, American Statistical Association","author":"VanRaden MJ","year":"1997"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/40.3-4.306"},{"key":"e_1_2_1_10_2","volume-title":"Numerical Mathematics and Computing","author":"Cheney W","year":"1985"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02295996"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.2307\/2532006"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780091208"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.4.939"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780130109"}],"container-title":["Statistics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsim.1017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sim.1017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T11:58:43Z","timestamp":1700222323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sim.1017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2,19]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,3,15]]}},"alternative-id":["10.1002\/sim.1017"],"URL":"https:\/\/doi.org\/10.1002\/sim.1017","archive":["Portico"],"relation":{},"ISSN":["0277-6715","1097-0258"],"issn-type":[{"value":"0277-6715","type":"print"},{"value":"1097-0258","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2,19]]}}}