{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T14:40:18Z","timestamp":1734100818331,"version":"3.30.2"},"reference-count":48,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KO 4680\/4\u20101"],"award-info":[{"award-number":["KO 4680\/4\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Statistics in Medicine"],"published-print":{"date-parts":[[2024,12,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In many trials and experiments, subjects are not only observed once but multiple times, resulting in a cluster of possibly correlated observations (e.g., brain regions per patient). Observations often do not fulfill model assumptions of mixed models and require the use of nonparametric methods. In this article, we develop and present a purely nonparametric rank\u2010based procedure that flexibly allows the unbiased and consistent estimation of the Wilcoxon\u2013Mann\u2013Whitney effect  in clustered data designs. Compared with existing methods, we allow flexible weights to be used in effect estimation. Additionally, we develop global and multiple contrast test procedures to test null hypotheses formulated regarding the generalized Mann\u2013Whitney effects and for the computation of range\u2010preserving simultaneous confidence intervals in a unified way. Extensive simulation studies show that these methods control the type\u2010I error rate well and have reasonable power to detect alternatives in various situations.<\/jats:p>","DOI":"10.1002\/sim.10262","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T10:15:13Z","timestamp":1731320113000},"page":"5650-5666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A General Framework for the Multiple Nonparametric Behrens\u2013Fisher Problem With Dependent Replicates"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9422-7788","authenticated-orcid":false,"given":"Erin","family":"Spr\u00fcnken","sequence":"first","affiliation":[{"name":"Institute of Biometry and Clinical Epidemiology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Mertens","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-2076","authenticated-orcid":false,"given":"Frank","family":"Konietschke","sequence":"additional","affiliation":[{"name":"Institute of Biometry and Clinical Epidemiology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529876"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533552"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0300-6"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1198\/jasa.2009.0116"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2012-014"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1214\/088342304000000549"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v014.i07"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2003.00125.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214504000001583"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2005.00389.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/biom.12447"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3758(96)00177-2"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2016.06.016"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8918"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10485250903469728"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8343"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201900310"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jspi.2022.05.009"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-02914-2"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2011.01020.x"},{"key":"e_1_2_13_22_1","first-page":"140","article-title":"Bayesian Estimation of Reliability in the Stress\u2010Strength Context","volume":"73","author":"Johnstone M. A.","year":"1983","journal-title":"Journal of the Washington Academy of Sciences"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/09622802211046389"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804622"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326077"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0097422"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541-0420.00005"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6277"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280220928572"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/sym14020244"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/insr.12418"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1997.10473623"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00031305.2021.1972836"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican1270-110"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/00029890.1994.11996968"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/0025570X.2001.11953065"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/rssb.12222"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1997.10473671"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2010.02.019"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/00949650802482386"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4036(200011)42:7<837::AID-BIMJ837>3.0.CO;2-S"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1214\/12-EJS691"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1515\/ijb-2012-0020"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jspi.2007.10.015"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177697819"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003620000039"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177730491"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3000"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2023-029"}],"container-title":["Statistics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sim.10262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T14:11:58Z","timestamp":1734099118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sim.10262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":48,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2024,12,30]]}},"alternative-id":["10.1002\/sim.10262"],"URL":"https:\/\/doi.org\/10.1002\/sim.10262","archive":["Portico"],"relation":{},"ISSN":["0277-6715","1097-0258"],"issn-type":[{"type":"print","value":"0277-6715"},{"type":"electronic","value":"1097-0258"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"2024-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}