{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:10:11Z","timestamp":1700244611489},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2003,5,2]],"date-time":"2003-05-02T00:00:00Z","timestamp":1051833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Statistics in Medicine"],"published-print":{"date-parts":[[2003,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For diseases that involve the immune system, the alleles of the human leukocyte antigen (HLA) complex can play a major role. For example, if responsiveness to therapy is immunologically mediated, one would think that responders and non\u2010responders might tend to have different HLA alleles. However, comparing the frequencies between the two groups of patients at each allele can introduce a substantial multiple comparisons problem as the number of alleles is large. This paper proposes an efficient two\u2010stage procedure for identifying alleles that may mediate response. In the first\u2010stage, the distribution of all alleles for the patients are compared to a reference population and a few alleles are selected. These candidate alleles are then compared between the two groups of patients using a modest Bonferroni correction. The two\u2010stage procedure strongly controls the type I error rate as the first\u2010stage selection is statistically independent of the second\u2010stage tests. We analyse a cohort of patients with bone marrow failure who are classified as responders or non\u2010responders to immunosuppressive therapy. Published in 2003 by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/sim.1426","type":"journal-article","created":{"date-parts":[[2003,6,9]],"date-time":"2003-06-09T10:09:11Z","timestamp":1055153351000},"page":"1999-2013","source":"Crossref","is-referenced-by-count":1,"title":["Comparing HLA antigen frequencies between two groups of patients"],"prefix":"10.1002","volume":"22","author":[{"given":"Dean A.","family":"Follmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,5,2]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"151","volume-title":"The Lymphocyte","author":"Tiwari JL","year":"1981"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2307\/2530055"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780020109"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2307\/2530908"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531409"},{"key":"e_1_2_1_7_2","unstructured":"TsujiK AizawaM SazazukiT. HLA\u20101991 Proceedings of the Eleventh International Workshop and Conference. Yokohama Japan 6\u201313 November1991 volume I 1066\u20131220."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.2307\/2532495"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1995.tb01608.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000022901"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780141103"},{"key":"e_1_2_1_12_2","first-page":"1049","volume-title":"Manual of Clinical Immunology","author":"Svejgaard A","year":"1980"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199710150-00014"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.13.3513"}],"container-title":["Statistics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsim.1426","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sim.1426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T17:37:11Z","timestamp":1700242631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sim.1426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5,2]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,6,30]]}},"alternative-id":["10.1002\/sim.1426"],"URL":"https:\/\/doi.org\/10.1002\/sim.1426","archive":["Portico"],"relation":{},"ISSN":["0277-6715","1097-0258"],"issn-type":[{"value":"0277-6715","type":"print"},{"value":"1097-0258","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5,2]]}}}