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For obvious reason the outcomes are then recorded as multiple discrete indicators with natural ordering. But in view of the reduced amount of information, the modeling of such data becomes intrinsically more difficult than that of continuous data. The primary concern in this study is to analyze a one\u2010compartmental PK model for ordinal data that can be used to describe the change in the concentration of drug over time. A flexible Monte Carlo EM\u2010based two\u2010step estimation method is proposed. Such a method is, in general, capable of analyzing a reasonably wide class of nonlinear mixed models. The modeling strategy is applied to a Phase I study of the drug Divalproex and its metabolite, developed for the treatment of epilepsy. The model's performance is evaluated through simulation. 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