{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:45:25Z","timestamp":1760100325243,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM076672"],"award-info":[{"award-number":["GM076672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Statistics in Medicine"],"published-print":{"date-parts":[[2011,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Timely detection of clusters of localized influenza activity in excess of background seasonal levels could improve situational awareness for public health officials and health systems. However, no single data type may capture influenza activity with optimal sensitivity, specificity, and timeliness, and it is unknown which data types could be most useful for surveillance. We compared the performance of 10 types of electronic clinical data for timely detection of influenza clusters throughout the 2007\/08 influenza season in northern California. Kaiser Permanente Northern California generated zip code\u2010specific daily episode counts for: influenza\u2010like illness (ILI) diagnoses in ambulatory care (AC) and emergency departments (ED), both with and without regard to fever; hospital admissions and discharges for pneumonia and influenza; antiviral drugs dispensed (Rx); influenza laboratory tests ordered (Tests); and tests positive for influenza type A (FluA) and type B (FluB). Four credible events of localized excess illness were identified. Prospective surveillance was mimicked within each data stream using a space\u2013time permutation scan statistic, analyzing only data available as of each day, to evaluate the ability and timeliness to detect the credible events. AC without fever and Tests signaled during all four events and, along with Rx, had the most timely signals. FluA had less timely signals. ED, hospitalizations, and FluB did not signal reliably. When fever was included in the ILI definition, signals were either delayed or missed. Although limited to one health plan, location, and year, these results can inform the choice of data streams for public health surveillance of influenza. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/sim.3883","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T13:39:29Z","timestamp":1297949969000},"page":"549-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Timely detection of localized excess influenza activity in Northern California across patient care, prescription, and laboratory data"],"prefix":"10.1002","volume":"30","author":[{"given":"Sharon K.","family":"Greene","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kulldorff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Brand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth P.","family":"Kleinman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Platt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125237"},{"key":"e_1_2_7_3_2","unstructured":"Global Alert and Response World Health Organization. Preparing for the second wave: lessons from current outbreaks Geneva Switzerland 2009. Available from:http:\/\/www.who.int\/csr\/disease\/swineflu\/notes\/h1n1_second_wave_20090828\/en\/index.html accessed 31 August2009."},{"key":"e_1_2_7_4_2","first-page":"141","article-title":"Syndromic surveillance on the epidemiologist's desktop: making sense of much data","volume":"54","author":"Hurt\u2010Mullen KJ","journal-title":"MMWR Morbidity and Mortality Weekly Report"},{"issue":"25","key":"e_1_2_7_5_2","first-page":"692","article-title":"Centers for Disease Control and Prevention (CDC). Influenza activity\u2014United States and worldwide, 2007\u201308 season","volume":"57","year":"2008","journal-title":"MMWR Morbidity and Mortality Weekly Report"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-6405.2009.00391.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/bsp.2007.0056"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-8-18"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-7-250"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/593098"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07634"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005260"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1203.050573"},{"issue":"10","key":"e_1_2_7_14_2","first-page":"277","article-title":"Centers for Disease Control and Prevention (CDC). 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