{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:14:26Z","timestamp":1774602866064,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,10,12]],"date-time":"2006-10-12T00:00:00Z","timestamp":1160611200000},"content-version":"vor","delay-in-days":6554,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Statistics in Medicine"],"published-print":{"date-parts":[[1988,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Remission duration data from two observational studies, the German ALL\/AUL study on acute lymphoblastic and acute undifferentiated leukaemia and the Kiel Lymphoma Study, are used to demonstrate the adequacy of an interval\u2010censoring approach. The Turnbull estimator is contrasted with the conventionally used Kaplan\u2014Meier estimator. In addition, a parametric model is used for estimation or simulation of the delay times of complete remission diagnosis and relapse diagnosis. Two possible consequences of the conventional approach are discussed: biased estimation (for example, overestimation of remission duration), and underestimation of the true error variance, which may lead to false positive results. On the other hand, the applicability of the interval\u2010censoring approach is doubtful when the censoring mechanism (examination pattern, patient's behaviour) is confounded with the endpoints.<\/jats:p>","DOI":"10.1002\/sim.4780071106","type":"journal-article","created":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T17:17:02Z","timestamp":1177435022000},"page":"1139-1145","source":"Crossref","is-referenced-by-count":49,"title":["Remission duration: An example of interval\u2010censored observations"],"prefix":"10.1002","volume":"7","author":[{"given":"Gerta","family":"R\u00fccker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorle","family":"Messerer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1200\/JCO.1984.2.9.1040","article-title":"Influence of measurement error on assessment of response to anticancer chemotherapy: Proposal for new criteria of tumor response","volume":"2","author":"Warr D.","year":"1984","journal-title":"Journal of Clinical Oncology"},{"issue":"287","key":"e_1_2_1_3_2","article-title":"Letter to the Editor","volume":"3","author":"Perry D. J.","year":"1985","journal-title":"Journal of Clinical Oncology"},{"issue":"287","key":"e_1_2_1_4_2","article-title":"Reply","volume":"3","author":"Tannock I.","year":"1985","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2307\/2530698"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.2517-6161.1976.tb01597.x","article-title":"The empirical distribution function with arbitrarily grouped, censored and truncated data","volume":"38","author":"Turnbull B. W.","year":"1976","journal-title":"Journal of the Royal Statistical Society, Series B"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_1_8_2","volume-title":"Survival Analysis","author":"Miller R. G.","year":"1981"},{"key":"e_1_2_1_9_2","volume-title":"Analysis of Survival data","author":"Cox D. R.","year":"1984"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V64.1.38.38","article-title":"Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults","volume":"64","author":"Hoelzer D.","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900020306"},{"key":"e_1_2_1_12_2","unstructured":"Gr\u00fcger J. \u2018Nichtparametrische Analyse sporadisch beobachtbarer Krankheitsverlaufsdaten\u2019 PhD thesis Dortmund 1986."}],"container-title":["Statistics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsim.4780071106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sim.4780071106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T21:59:06Z","timestamp":1736978346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sim.4780071106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1988,11]]}},"alternative-id":["10.1002\/sim.4780071106"],"URL":"https:\/\/doi.org\/10.1002\/sim.4780071106","archive":["Portico"],"relation":{},"ISSN":["0277-6715","1097-0258"],"issn-type":[{"value":"0277-6715","type":"print"},{"value":"1097-0258","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,11]]}}}