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Whether a drug starts as an active compound and gets metabolized and eliminated from the body or starts as an inactive compound and gets metabolized to an active form, patients in subgroups separated by polymorphism of a gene needed to metabolize the drug might derive differential benefit from that drug. With the use of the <jats:italic>C<\/jats:italic>lopidogrel in <jats:italic>U<\/jats:italic>nstable Angina to Prevent <jats:italic>R<\/jats:italic>ecurrent <jats:italic>E<\/jats:italic>vents trial for Plavix as an example, this article proposes Multiple Comparisons with Control <jats:sub>Subgroup<\/jats:sub> and Multiple Comparisons with the Best <jats:sub>Subgroup<\/jats:sub> as methods to infer whether some subgroups of patients derive more or less benefit than wild\u2010type patients and which subgroup or subgroups of patients derive maximum benefit or practically maximum benefit from the drug. 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