{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T17:20:13Z","timestamp":1774632013967,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2012,12,3]],"date-time":"2012-12-03T00:00:00Z","timestamp":1354492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1002,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Statistics in Medicine"],"published-print":{"date-parts":[[2013,6,30]]},"abstract":"<jats:p>We consider a marginal model for the regression analysis of clustered failure time data with a cure fraction. We propose to use novel generalized estimating equations in an expectation\u2013maximization algorithm to estimate regression parameters in a semiparametric proportional hazards mixture cure model. The dependence among the cure statuses and among the survival times of uncured patients within clusters are modeled by working correlation matrices in the estimating equations. We use a bootstrap method to obtain the variances of the estimates. We report a simulation study to demonstrate a substantial efficiency gain of the proposed method over an existing marginal method. Finally, we apply the model and the proposed method to a set of data from a multi\u2010institutional study of tonsil cancer patients treated with a radiation therapy. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/sim.5687","type":"journal-article","created":{"date-parts":[[2012,12,3]],"date-time":"2012-12-03T11:02:49Z","timestamp":1354532569000},"page":"2364-2373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A semiparametric marginal mixture cure model for clustered survival data"],"prefix":"10.1002","volume":"32","author":[{"given":"Yi","family":"Niu","sequence":"first","affiliation":[{"name":"Department of Mathematics and Statistics Queen's University  Kingston ON Canada K7L 3N6"},{"name":"Cancer Care and Epidemiology Queen's Cancer Research Institute  Kingston ON Canada K7L 3N6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingwei","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics Queen's University  Kingston ON Canada K7L 3N6"},{"name":"Department of Community Health and Epidemiology Queen's University  Kingston ON Canada K7L 3N6"},{"name":"Cancer Care and Epidemiology Queen's Cancer Research Institute  Kingston ON Canada K7L 3N6"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532991"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10985\u2010007\u20109042\u20104"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2007.04.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2011.09.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmva.2000.1975"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3371"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006\u2010341X.2001.00779.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006\u2010341X.2003.00135.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.932"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3404"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4098"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.13"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006\u2010341X.2000.00237.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006\u2010341X.2000.00227.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780121103"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118032985"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/87.2.391"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-4541-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2205"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2307\/2684460"},{"key":"e_1_2_8_22_1","unstructured":"ByK QaqishiB.mvtBinaryEP: Generates Correlated Binary Data 2011.http:\/\/cran.r\u2010project.org\/web\/packages\/mvtBinaryEP\/index.html R package version 1.0.1 (Accessed September 6 2011)."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/65.1.141"}],"container-title":["Statistics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsim.5687","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sim.5687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T19:59:35Z","timestamp":1698523175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sim.5687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,3]]},"references-count":22,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2013,6,30]]}},"alternative-id":["10.1002\/sim.5687"],"URL":"https:\/\/doi.org\/10.1002\/sim.5687","archive":["Portico"],"relation":{},"ISSN":["0277-6715","1097-0258"],"issn-type":[{"value":"0277-6715","type":"print"},{"value":"1097-0258","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,3]]},"assertion":[{"value":"2012-12-03","name":"published_online","label":"Published Online","group":{"name":"publication_history","label":"Publication History"}}]}}