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In the trial, both the non\u2010adherence rate and the rate of loss to follow\u2010up are fairly high. To estimate the effect of the treatment received on the outcome, we use the generalized structural mean model (GSMM), originally proposed to deal with non\u2010adherence, to adjust for both non\u2010adherence and loss to follow\u2010up. In the model, loss to follow\u2010up is handled by weighting the estimation equations for GSMM with one over the probability of not being lost to follow\u2010up, estimated using a logistic regression model. We re\u2010analyzed the data from the trial and found a possible benefit of amitriptyline when administered at a high\u2010dose level. 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