{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:33:51Z","timestamp":1790130831616,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2013,1,27]],"date-time":"2013-01-27T00:00:00Z","timestamp":1359244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,1,27]],"date-time":"2013-01-27T00:00:00Z","timestamp":1359244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,1,27]],"date-time":"2013-01-27T00:00:00Z","timestamp":1359244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Statistics in Medicine"],"published-print":{"date-parts":[[2013,7,20]]},"abstract":"<jats:p>Previous authors have proposed the sequential parallel comparison design (SPCD) to address the issue of high placebo response rate in clinical trials. The original use of SPCD focused on binary outcomes, but recent use has since been extended to continuous outcomes that arise more naturally in many fields, including psychiatry. Analytic methods proposed to date for analysis of SPCD trial continuous data included methods based on seemingly unrelated regression and ordinary least squares. Here, we propose a repeated measures linear model that uses all outcome data collected in the trial and accounts for data that are missing at random. An appropriate contrast formulated after the model has been fit can be used to test the primary hypothesis of no difference in treatment effects between study arms. Our extensive simulations show that when compared with the other methods, our approach preserves the type I error even for small sample sizes and offers adequate power and the smallest mean squared error under a wide variety of assumptions. We recommend consideration of our approach for analysis of data coming from SPCD trials. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/sim.5728","type":"journal-article","created":{"date-parts":[[2013,1,27]],"date-time":"2013-01-27T22:52:48Z","timestamp":1359327168000},"page":"2767-2789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["A repeated measures model for analysis of continuous outcomes in sequential parallel comparison design studies"],"prefix":"10.1002","volume":"32","author":[{"given":"Gheorghe","family":"Doros","sequence":"first","affiliation":[{"name":"Department of Biostatistics Boston University 801 Massachusetts Avenue Boston MA 02118 U.S.A."},{"name":"Harvard Clinical Research Institute (HCRI) 930 Commonwealth Avenue, 3rd floor Boston MA 02215 U.S.A."},{"name":"Massachusetts Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pencina","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Boston University 801 Massachusetts Avenue Boston MA 02118 U.S.A."},{"name":"Harvard Clinical Research Institute (HCRI) 930 Commonwealth Avenue, 3rd floor Boston MA 02215 U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Rybin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Boston University 801 Massachusetts Avenue Boston MA 02118 U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Meisner","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Boston University 801 Massachusetts Avenue Boston MA 02118 U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Fava","sequence":"additional","affiliation":[{"name":"Harvard Medical School Massachusetts General Hospital 55 Fruit Street, Bulfinch 351 Boston MA 02114 U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069738"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.1994.63"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.14.1840"},{"key":"e_1_2_11_5_1","unstructured":"FavaM SchoenfeldD.System and method for reducing the placebo effect in controlled clinical trials.2010. Available at:http:\/\/www.patentlens.net\/patentlens\/patent\/US_7840419\/en\/[Accessed on 20 July 2012]."},{"key":"e_1_2_11_6_1","unstructured":"FavaM SchoenfeldD.System and method for reducing the placebo effect in controlled clinical trials.2010. Available from:http:\/\/www.patentlens.net\/patentlens\/patent\/US_7647235\/en\/[Accessed on 20 July 2012]."},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","unstructured":"FavaM SchoenfeldD.System and method for reducing the placebo effect in controlled clinical trials.2011. Available from:http:\/\/www.patentlens.net\/patentlens\/patent\/US_7983936\/en\/[Accessed on 20 July 2012].","DOI":"10.1037\/e550192012-001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","unstructured":"FavaM SchoenfeldD.System and method for reducing the placebo effect in controlled clinical trials.2012. Available from:http:\/\/www.patentlens.net\/patentlens\/patent\/US_8145504\/en\/[Accessed on 20 July 2012].","DOI":"10.1037\/e550192012-001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","unstructured":"FavaM SchoenfeldD.System and method for reducing the placebo effect in controlled clinical trials.2012. Available from:http:\/\/www.patentlens.net\/patentlens\/patent\/US_8145505\/en\/[Accessed on 20 July 2012].","DOI":"10.1037\/e550192012-001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2011.04.006"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1198\/sbr.2010.08015"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4292"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4412"},{"key":"e_1_2_11_14_1","unstructured":"FavaM MischoulonD IosifescuD WitteJ PencinaM FlynnM HarperL LevyM RickelsK PollackM.A double\u2010blind placebo\u2010controlled study of aripiprazole adjunctive to antidepressant therapy (ADT) among depressed outpatients with inadequate response to prior ADT (ADAPT\u2010A Study). The 48th Annual Meeting of the American College of Neuropsychopharmacology 2009."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774507081217"},{"key":"e_1_2_11_16_1","volume-title":"The Prevention and Treatment of Missing Data in Clinical Trials","author":"(U.S.) NRC","year":"2010"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198524847.001.0001","volume-title":"Analysis of Longitudinal Data","author":"Diggle PJ","year":"2002"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420011180"},{"key":"e_1_2_11_19_1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332050"}],"container-title":["Statistics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsim.5728","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsim.5728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sim.5728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T03:00:47Z","timestamp":1714878047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sim.5728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,27]]},"references-count":19,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2013,7,20]]}},"alternative-id":["10.1002\/sim.5728"],"URL":"https:\/\/doi.org\/10.1002\/sim.5728","archive":["Portico"],"relation":{},"ISSN":["0277-6715","1097-0258"],"issn-type":[{"value":"0277-6715","type":"print"},{"value":"1097-0258","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,27]]}}}