{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:07:26Z","timestamp":1791439646187,"version":"4.3.3"},"reference-count":49,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":132,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL095086"],"award-info":[{"award-number":["HL095086"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Statistics in Medicine"],"published-print":{"date-parts":[[2015,9,10]]},"abstract":"<jats:p>Sexually transmitted infections (STIs) with <jats:italic>Chlamydia trachomatis<\/jats:italic>, <jats:italic>Neisseria gonorrhoeae<\/jats:italic>, and <jats:italic>Trichomonas vaginalis<\/jats:italic> are among the most common infectious diseases in the United States, disproportionately affecting young women. Because a significant portion of the infections present no symptoms, infection control relies primarily on disease screening. However, universal STI screening in a large population can be expensive. In this paper, we propose a semiparametric model\u2010based screening algorithm. The model quantifies organism\u2010specific infection risks in individual subjects and accounts for the within\u2010subject interdependence of the infection outcomes of different organisms and the serial correlations among the repeated assessments of the same organism. Bivariate thin\u2010plate regression spline surfaces are incorporated to depict the concurrent influences of age and sexual partners on infection acquisition. Model parameters are estimated by using a penalized likelihood method. For inference, we develop a likelihood\u2010based resampling procedure to compare the bivariate effect surfaces across outcomes. Simulation studies are conducted to evaluate the model fitting performance. A screening algorithm is developed using data collected from an epidemiological study of young women at increased risk of STIs. We present evidence that the three organisms have distinct age and partner effect patterns; for <jats:italic>C. trachomatis<\/jats:italic>, the partner effect is more pronounced in younger adolescents. Predictive performance of the proposed screening algorithm is assessed through a receiver operating characteristic analysis. We show that the model\u2010based screening algorithm has excellent accuracy in identifying individuals at increased risk, and thus can be used to assist STI screening in clinical practice. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/sim.6515","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T06:07:10Z","timestamp":1429682830000},"page":"2844-2857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A sexually transmitted infection screening algorithm based on semiparametric regression models"],"prefix":"10.1002","volume":"34","author":[{"given":"Zhuokai","family":"Li","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute  2400 Pratt Street Durham NC 27705 U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Indiana University Schools of Medicine and Public Health  410 West 10th Street Indianapolis IN 46202 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